Sonic hedgehog in normal and neoplastic proliferation: insight gained from human tumors and animal models (Q35062435)

6 August 2017

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title

Sonic hedgehog in normal and neoplastic proliferation: insight gained from human tumors and animal models (English)

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6 August 2017

Cynthia Wetmore

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6 August 2017

publication date

1 February 2003

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Current Opinion in Genetics & Development

6 August 2017

published in

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

34-42

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Modelling the molecular circuitry of cancer

6 August 2017

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7 January 2021

The hedgehog pathway and basal cell carcinomas

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7 January 2021

Hedgehog and patched in neural development and disease

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7 January 2021

The developmental biology of brain tumors.

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7 January 2021

Hedgehog signaling in animal development: paradigms and principles

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7 January 2021

Sonic hedgehog signaling by the patched-smoothened receptor complex

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7 January 2021

Hedgehog signal transduction: recent findings

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7 January 2021

Patched acts catalytically to suppress the activity of Smoothened

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7 January 2021

Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog

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7 January 2021

Sonic hedgehog in the nervous system: functions, modifications and mechanisms

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7 January 2021

Sonic hedgehog in CNS development: one signal, multiple outputs

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7 January 2021

Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1

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7 January 2021

Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

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7 January 2021

Gli genes in development and cancer

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7 January 2021

Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32.

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7 January 2021

Ptc1 and Ptc2 transcripts provide distinct readouts of Hedgehog signaling activity during chick embryogenesis.

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7 January 2021

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

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7 January 2021

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

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7 January 2021

Nevoid basal-cell carcinoma syndrome

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7 January 2021

Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome

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7 January 2021

Activating Smoothened mutations in sporadic basal-cell carcinoma

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7 January 2021

A frequent activated smoothened mutation in sporadic basal cell carcinomas

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7 January 2021

Mutations in SUFU predispose to medulloblastoma

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7 January 2021

Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1

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7 January 2021

Vertebrate homologs of Drosophila suppressor of fused interact with the gli family of transcriptional regulators

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7 January 2021

Prediction of central nervous system embryonal tumour outcome based on gene expression

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7 January 2021

Paediatric embryonic brain tumours. biological and clinical relevance of molecular genetic abnormalities

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7 January 2021

Medulloblastoma: clinical and biologic aspects

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7 January 2021

The cells and molecules that make a cerebellum.

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7 January 2021

Neuronal migration, with special reference to developing human brain: a review

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7 January 2021

Gli and hedgehog in cancer: tumours, embryos and stem cells.

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7 January 2021

Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum

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7 January 2021

Altered neural cell fates and medulloblastoma in mouse patched mutants

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7 January 2021

Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome

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7 January 2021

Hedgehog signaling and human disease

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7 January 2021

Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport.

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7 January 2021

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

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7 January 2021

Medulloblastoma growth inhibition by hedgehog pathway blockade

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7 January 2021

Accommodating haploinsufficient tumor suppressor genes in Knudson's model

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7 January 2021

Haplo-insufficiency? Let me count the ways

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7 January 2021

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

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7 January 2021

Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation

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7 January 2021

Unbalanced overexpression of the mutant allele in murine Patched mutants

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7 January 2021

Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome

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7 January 2021

Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice

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7 January 2021

Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours

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7 January 2021

The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas

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7 January 2021

Developmental genes and cancer: role of patched in basal cell carcinoma of the skin

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7 January 2021

Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein

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https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900002-9

7 January 2021

Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma.

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https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900002-9

7 January 2021

Basal cell carcinomas in mice overexpressing sonic hedgehog

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https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900002-9

7 January 2021

Basal cell carcinomas in mice overexpressing Gli2 in skin

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https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900002-9

7 January 2021

Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

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7 January 2021

Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog

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https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900002-9

7 January 2021

Complications of the nevoid basal cell carcinoma syndrome: a case report

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https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900002-9

7 January 2021

High incidence of medulloblastoma following X-ray-irradiation of newborn Ptc1 heterozygous mice

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https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900002-9

7 January 2021

Sonic hedgehog opposes epithelial cell cycle arrest

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https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900002-9

7 January 2021

Patched1 interacts with cyclin B1 to regulate cell cycle progression

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https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900002-9

7 January 2021

Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors

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https://api.crossref.org/works/10.1016%2FS0959-437X%2803%2900002-9

7 January 2021

10.1016/S0959-437X(03)00002-9

Identifiers

DOI

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6 August 2017

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