MX1013, a dipeptide caspase inhibitor with potent in vivo antiapoptotic activity (Q35045715)

6 August 2017

title

MX1013, a dipeptide caspase inhibitor with potent in vivo antiapoptotic activity (English)

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6 August 2017

Wu Yang

1 reference

6 August 2017

John Guastella

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6 August 2017

Jin-Cheng Huang

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6 August 2017

Yan Wang

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6 August 2017

Li Zhang

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6 August 2017

Dong Xue

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6 August 2017

Minhtam Tran

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6 August 2017

Richard Woodward

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6 August 2017

Shailaja Kasibhatla

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6 August 2017

Ben Tseng

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6 August 2017

John Drewe

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6 August 2017

Sui Xiong Cai

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6 August 2017

language of work or name

English

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publication date

26 August 2003

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British Journal of Pharmacology

6 August 2017

published in

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6 August 2017

volume

140

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6 August 2017

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6 August 2017

page(s)

402-412

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Apoptosis-based therapies

6 August 2017

cites work

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Is caspase-3 inhibition a valid therapeutic strategy in cerebral ischemia?

8 July 2018

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8 July 2018

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In vivo myocardial infarct size reduction by a caspase inhibitor administered after the onset of ischemia

8 July 2018

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The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity

8 July 2018

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Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Caspases: enemies within

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8 July 2018

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

8 July 2018

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Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

8 July 2018

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Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone

8 July 2018

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Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death

8 July 2018

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An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat.

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

8 July 2018

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Myocardial infarction in rats. Infarct size, myocyte hypertrophy, and capillary growth

8 July 2018

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The behavior and significance of slow-binding enzyme inhibitors

8 July 2018

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New Fluorogenic Substrates for α-Thrombin, Factor Xa, Kallikreins, and Urokinase1

8 July 2018

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Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury

8 July 2018

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Characterization of the caspase inhibitor IDN-1965 in a model of apoptosis-associated liver injury.

25 October 2018

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Protection against TNF-induced liver parenchymal cell apoptosis during endotoxemia by a novel caspase inhibitor in mice

25 October 2018

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Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury

25 October 2018

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Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family

25 October 2018

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25 October 2018

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(p-Amidinophenyl)methanesulfonyl fluoride, an irreversible inhibitor of serine proteases

25 October 2018

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Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization

25 October 2018

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12 December 2020

A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis

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12 December 2020

A specific inhibitor of apoptosis decreases tissue injury after intestinal ischemia-reperfusion in mice

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12 December 2020

Apoptosis: basic mechanisms and implications for cardiovascular disease

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12 December 2020

New fluorogenic substrates for renin

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12 December 2020

Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor

1 reference

12 December 2020

Photometric or fluorometric assay of cathepsin B, L and H and papain using substrates with an aminotrifluoromethylcoumarin leaving group

1 reference

12 December 2020

Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones

1 reference

12 December 2020

Essential roles of the Fas ligand in the development of hepatitis

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12 December 2020

Identifiers

DOI

10.1038/SJ.BJP.0705450

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6 August 2017

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6 August 2017

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