Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk (Q35037346)

5 August 2017

title

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk (English)

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5 August 2017

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5 August 2017

Jonathan Cooper

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5 August 2017

Gary R Mirams

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Yi Cui

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5 August 2017

Anna Sher

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5 August 2017

Martin Fink

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5 August 2017

Bronagh M Heath

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5 August 2017

Nick C McMahon

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5 August 2017

Denis Noble

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5 August 2017

publication date

7 February 2011

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5 August 2017

published in

Cardiovascular Research

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5 August 2017

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5 August 2017

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5 August 2017

page(s)

53-61

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A novel computational model of the human ventricular action potential and Ca transient

5 August 2017

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Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends

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Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs.

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8 July 2018

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

21 January 2018

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Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Discontinuation of thioridazine. Risks must be balanced

8 July 2018

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21 January 2018

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Torsade de pointes in a patient with complex medical and psychiatric conditions receiving low-dose quetiapine

21 January 2018

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12 December 2020

Alternans and spiral breakup in a human ventricular tissue model

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12 December 2020

From the Food and Drug Administration

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12 December 2020

Discontinuation of thioridazine. What happened to thioridazine?

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12 December 2020

Identifiers

DOI

10.1093/CVR/CVR044

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5 August 2017

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5 August 2017

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