The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression (Q35029589)

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English	The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression	scientific article

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22 January 2020

The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression (English)

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22 January 2020

Alexander Dobrovic

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22 January 2020

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22 January 2020

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22 January 2020

Nicola J Waddell

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22 January 2020

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22 January 2020

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22 January 2020

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Katie T Huang

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22 January 2020

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Sandra A O'Toole

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22 January 2020

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Andreas Möller

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22 January 2020

Mira C P Liu

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22 January 2020

Jaclyn E Sceneay

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22 January 2020

Christina S F Wong

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22 January 2020

Catriona M McNeil

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22 January 2020

Robert L Sutherland

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22 January 2020

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9 February 2011

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22 January 2020

Breast Cancer Research

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21306611%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

13

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22 January 2020

1

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22 January 2020

R19

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22 January 2020

copyright license

Creative Commons Attribution 2.0 Generic

1 February 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

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Subtypes of familial breast tumours revealed by expression and copy number profiling

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Siah proteins: novel drug targets in the Ras and hypoxia pathways

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Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis

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Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis

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The ubiquitin ligase Siah2 and the hypoxia response

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The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy.

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High frequency of TP53 mutation in BRCA1 and sporadic basal-like carcinomas but not in BRCA1 luminal breast tumors

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8 July 2018

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

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8 July 2018

BAG-1 predicts patient outcome and tamoxifen responsiveness in ER-positive invasive ductal carcinoma of the breast.

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Effect of disrupting seven-in-absentia homolog 2 function on lung cancer cell growth

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8 July 2018

The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways

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8 July 2018

Inhibition of Siah ubiquitin ligase function.

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Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer

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Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue.

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Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation

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8 July 2018

Siah-1 facilitates ubiquitination and degradation of factor inhibiting HIF-1alpha (FIH).

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Estrogen down-regulation of the corepressor N-CoR: mechanism and implications for estrogen derepression of N-CoR-regulated genes

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An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival

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Pharmacogenomic predictor of sensitivity to preoperative chemotherapy with paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide in breast cancer

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Downregulation of SIAH2, an ubiquitin E3 ligase, is associated with resistance to endocrine therapy in breast cancer

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Overexpression of hypoxia-inducible factor HIF-1alpha predicts early relapse in breast cancer: retrospective study in a series of 745 patients

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12 December 2020

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10.1186/BCR2828

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22 January 2020

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22 January 2020

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22 January 2020

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