Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21 (Q35019514)

5 August 2017

title

Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21 (English)

1 reference

5 August 2017

1 reference

Elena Sanchez

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Jennifer A Kelly

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Robert P Kimberly

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Marta E Alarcón-Riquelme

object named as

Marta E Alarcón-Riquelme

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Javier Martín

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Timothy J Vyse

1 reference

5 August 2017

John D Reveille

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5 August 2017

Michelle Petri

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5 August 2017

John B Harley

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5 August 2017

Judith A James

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5 August 2017

Carl D Langefeld

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5 August 2017

Gary S Gilkeson

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5 August 2017

Patrick M Gaffney

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5 August 2017

Julie Ziegler

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5 August 2017

Graciela S Alarcón

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5 August 2017

Joan T Merrill

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5 August 2017

Rosalind Ramsey-Goldman

object named as

Rosalind Ramsey-Goldman

1 reference

5 August 2017

Jeffrey C Edberg

1 reference

5 August 2017

Xana Kim-Howard

1 reference

5 August 2017

Swapan K Nath

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5 August 2017

Travis Hughes

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5 August 2017

Amr H Sawalha

1 reference

5 August 2017

Kenneth M Kaufman

1 reference

5 August 2017

Elizabeth E Brown

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5 August 2017

Luis M Vilá

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5 August 2017

Kathy L Moser

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5 August 2017

BIOLUPUS Network

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5 August 2017

publication date

1 June 2011

1 reference

5 August 2017

published in

Arthritis & Rheumatology

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5 August 2017

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5 August 2017

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5 August 2017

page(s)

1689-1697

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Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus

5 August 2017

cites work

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Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locus

8 July 2018

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Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus

8 July 2018

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A polymorphism within IL21R confers risk for systemic lupus erythematosus

8 July 2018

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8 July 2018

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Review of recent genome-wide association scans in lupus

8 July 2018

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Th17 cells in rheumatoid arthritis and systemic lupus erythematosus

8 July 2018

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Novel association of the interleukin 2-interleukin 21 region with inflammatory bowel disease.

8 July 2018

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8 July 2018

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Follicular helper T cells are required for systemic autoimmunity

8 July 2018

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Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis

8 July 2018

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A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice

8 July 2018

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Interleukin 21 as a target of intervention in autoimmune disease

8 July 2018

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Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America

8 July 2018

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Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

8 July 2018

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Development and characterization of IL-21-producing CD4+ T cells

8 July 2018

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IL-21 and TGF-beta are required for differentiation of human T(H)17 cells

8 July 2018

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A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci

8 July 2018

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8 July 2018

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

8 July 2018

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IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

8 July 2018

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IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

8 July 2018

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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

8 July 2018

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A genomewide single-nucleotide-polymorphism panel for Mexican American admixture mapping

8 July 2018

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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106139

IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression.

8 July 2018

1 reference

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Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

8 July 2018

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A function for interleukin 2 in Foxp3-expressing regulatory T cells

8 July 2018

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Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling

8 July 2018

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Examination of ancestry and ethnic affiliation using highly informative diallelic DNA markers: application to diverse and admixed populations and implications for clinical epidemiology and forensic medicine

8 July 2018

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A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

8 July 2018

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8 July 2018

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Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

8 July 2018

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Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosus

8 July 2018

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8 July 2018

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Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases

8 July 2018

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Crossref

https://api.crossref.org/works/10.1002%2FART.30320

Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FART.30320

Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FART.30320

Interleukin 2 deficiency is a common feature of autoimmune mice

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21425124

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/ART.30320

1 reference

5 August 2017

1 reference

5 August 2017

1 reference