Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells (Q34994576)

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English	Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells	scientific article

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scholarly article

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Europe PubMed Central

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5 August 2017

Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells (English)

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Europe PubMed Central

PubMed publication ID

5 August 2017

author name string

Warren Fiskus

1

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5 August 2017

Yongchao Wang

2

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5 August 2017

Arun Sreekumar

3

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5 August 2017

Kathleen M Buckley

4

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5 August 2017

Huidong Shi

5

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5 August 2017

Anand Jillella

6

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5 August 2017

Celalettin Ustun

7

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5 August 2017

Rekha Rao

8

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5 August 2017

Pravina Fernandez

9

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5 August 2017

Jianguang Chen

10

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5 August 2017

Ramesh Balusu

11

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5 August 2017

Sanjay Koul

12

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5 August 2017

Peter Atadja

13

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5 August 2017

Victor E Marquez

14

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5 August 2017

Kapil N Bhalla

15

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5 August 2017

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28 July 2009

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5 August 2017

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5 August 2017

114

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5 August 2017

13

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5 August 2017

2733-2743

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5 August 2017

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2756128/fullTextXML

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Panobinostat treatment depletes EZH2 and DNMT1 levels and enhances decitabine mediated de-repression of JunB and loss of survival of human acute leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

Dysregulation of the C/EBPalpha differentiation pathway in human cancer

1 reference

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8 July 2018

Cotreatment with BCL-2 antagonist sensitizes cutaneous T-cell lymphoma to lethal action of HDAC7-Nur77-based mechanism.

1 reference

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8 July 2018

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer

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8 July 2018

Cotreatment with vorinostat enhances activity of MK-0457 (VX-680) against acute and chronic myelogenous leukemia cells.

1 reference

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8 July 2018

Repression of E-cadherin by the polycomb group protein EZH2 in cancer

1 reference

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FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression

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8 July 2018

Roles of the EZH2 histone methyltransferase in cancer epigenetics

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8 July 2018

DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications

1 reference

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8 July 2018

Over-expression of polycomb group protein EZH2 relates to decreased expression of p16 INK4a in cholangiocarcinogenesis in hepatolithiasis

1 reference

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8 July 2018

You spin me round: MaFBx/Atrogin-1 feeds forward on FOXO transcription factors (like a record).

1 reference

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8 July 2018

Mechanisms of resistance to histone deacetylase inhibitors and their therapeutic implications

1 reference

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8 July 2018

On the enzymatic properties of Dnmt1: specificity, processivity, mechanism of linear diffusion and allosteric regulation of the enzyme

1 reference

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8 July 2018

Importance of Ezh2 polycomb protein in tumorigenesis process interfering with the pathway of growth suppressive key elements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

1 reference

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8 July 2018

Genome regulation by polycomb and trithorax proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

The epigenomics of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

The mammalian epigenome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

Polycomb silencers control cell fate, development and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

Combined effects of novel tyrosine kinase inhibitor AMN107 and histone deacetylase inhibitor LBH589 against Bcr-Abl-expressing human leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

The Polycomb group protein EZH2 directly controls DNA methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

Mechanisms of tumor suppression by the SCF(Fbw7).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies

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8 July 2018

Mammalian DNA methyltransferase 1: inspiration for new directions

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8 July 2018

SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3.

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8 July 2018

The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

The polycomb group protein EZH2 is involved in progression of prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756128

8 July 2018

The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma

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8 July 2018

Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia

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8 July 2018

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

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8 July 2018

Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-L-homocysteine hydrolase inhibitor

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8 July 2018

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

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8 July 2018

Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation

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8 July 2018

Pharmacokinetics of the antiviral agent 3-deazaneplanocin A.

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

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8 July 2018

3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60.

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8 July 2018

Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells.

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26 October 2018

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

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26 October 2018

Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma.

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26 October 2018

HOX genes: not just myeloid oncogenes any more

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12 December 2020

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10.1182/BLOOD-2009-03-213496

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Europe PubMed Central

PubMed publication ID

5 August 2017

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Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

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Europe PubMed Central

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5 August 2017

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