Ex vivo gene therapy for HIV-1 treatment (Q34982851)

5 August 2017

1 reference

title

Ex vivo gene therapy for HIV-1 treatment (English)

1 reference

5 August 2017

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21505069

30 November 2024

Lisa J. Scherer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21505069

30 November 2024

John J. Rossi

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21505069

30 November 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21505069

30 November 2024

publication date

19 April 2011

1 reference

full work available at URL

5 August 2017

https://academic.oup.com/hmg/article-pdf/20/R1/R100/1766688/ddr160.pdf

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21505069

https://europepmc.org/articles/PMC3095057

30 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21505069

https://europepmc.org/articles/PMC3095057?pdf=render

30 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21505069

https://doi.org/10.1093/hmg/ddr160

30 November 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21505069

http://academic.oup.com/hmg/article-pdf/20/R1/R100/1766688/ddr160.pdf

30 November 2024

1 reference

https://api.crossref.org/works/10.1093/HMG/DDR160

30 November 2024

published in

Human Molecular Genetics

1 reference

5 August 2017

1 reference

5 August 2017

1 reference

5 August 2017

page(s)

R100-7

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JNK1 Is Required for Lentivirus Entry and Gene Transfer

5 August 2017

cites work

1 reference

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Hexagonal assembly of a restricting TRIM5alpha protein

8 July 2018

1 reference

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Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation

8 July 2018

1 reference

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The expanding universe of transposon technologies for gene and cell engineering.

8 July 2018

1 reference

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Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu

8 July 2018

1 reference

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Adaptation of HIV-1 to cells expressing rhesus monkey TRIM5α

8 July 2018

1 reference

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Host Genes Associated with HIV-1 Replication in Lymphatic Tissue

8 July 2018

1 reference

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In silico modeling indicates the development of HIV-1 resistance to multiple shRNA gene therapy differs to standard antiretroviral therapy

8 July 2018

1 reference

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High natural permissivity of primary rabbit cells for HIV-1, with a virion infectivity defect in macrophages as the final replication barrier

8 July 2018

1 reference

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The HIV-1 Central Polypurine Tract Functions as a Second Line of Defense against APOBEC3G/F

8 July 2018

1 reference

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Cytoplasmic Body Component TRIM5α Requires Lipid-enriched Microdomains for Efficient HIV-1 Restriction

8 July 2018

1 reference

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Survival of the fittest: positive selection of CD4+ T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection

8 July 2018

1 reference

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The use of cell-delivered gene therapy for the treatment of HIV/AIDS

8 July 2018

1 reference

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The challenge of obtaining therapeutic levels of genetically modified hematopoietic stem cells in beta-thalassemia patients

8 July 2018

1 reference

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Computational models of HIV-1 resistance to gene therapy elucidate therapy design principles

8 July 2018

1 reference

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Endogenous CD317/Tetherin limits replication of HIV-1 and murine leukemia virus in rodent cells and is resistant to antagonists from primate viruses.

8 July 2018

1 reference

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Human immunodeficiency virus (HIV)-1 infects human hepatic stellate cells and promotes collagen I and monocyte chemoattractant protein-1 expression: Implications for the pathogenesis of HIV/hepatitis C virus-induced liver fibrosis

8 July 2018

1 reference

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Designing and Testing Chimeric Zinc Finger Transposases

8 July 2018

1 reference

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P body-associated protein Mov10 inhibits HIV-1 replication at multiple stages

8 July 2018

1 reference

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Human APOBEC3G-mediated editing can promote HIV-1 sequence diversification and accelerate adaptation to selective pressure

8 July 2018

1 reference

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Translating Sleeping Beauty transposition into cellular therapies: victories and challenges

8 July 2018

1 reference

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Specific insertions of zinc finger domains into Gag-Pol yield engineered retroviral vectors with selective integration properties

8 July 2018

1 reference

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A single amino acid substitution of the human immunodeficiency virus type 1 capsid protein affects viral sensitivity to TRIM5 alpha

8 July 2018

1 reference

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Gene transfer efficiency and genome-wide integration profiling of Sleeping Beauty, Tol2, and piggyBac transposons in human primary T cells

8 July 2018

1 reference

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Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

8 July 2018

1 reference

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Moderate influence of human APOBEC3F on HIV-1 replication in primary lymphocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Tetherin restricts productive HIV-1 cell-to-cell transmission

8 July 2018

1 reference

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Absence of DICER in monocytes and its regulation by HIV-1.

8 July 2018

1 reference

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RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma

8 July 2018

1 reference

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HIV-1 Vif versus the APOBEC3 cytidine deaminases: an intracellular duel between pathogen and host restriction factors

8 July 2018

1 reference

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Anticipating and blocking HIV-1 escape by second generation antiviral shRNAs

8 July 2018

1 reference

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HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment

8 July 2018

1 reference

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Unexpectedly high copy number of random integration but low frequency of persistent expression of the Sleeping Beauty transposase after trans delivery in primary human T cells

8 July 2018

1 reference

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Generation of human induced pluripotent stem cells bearing an anti-HIV transgene by a lentiviral vector carrying an internal murine leukemia virus promoter

8 July 2018

1 reference

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APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis

8 July 2018

1 reference

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Productive replication of Vif-chimeric HIV-1 in feline cells

8 July 2018

1 reference

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Selection of genetically modified hematopoietic cells in vitro and in vivo using alkylating agent lysomustine

8 July 2018

1 reference

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Ebola virus glycoprotein counteracts BST-2/Tetherin restriction in a sequence-independent manner that does not require tetherin surface removal

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

TRIM5alpha disrupts the structure of assembled HIV-1 capsid complexes in vitro

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Hybrid lentiviral vectors

8 July 2018

1 reference

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Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment

8 July 2018

1 reference

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Comparative analysis of transposable element vector systems in human cells

8 July 2018

1 reference

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Generation of human TRIM5alpha mutants with high HIV-1 restriction activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction

8 July 2018

1 reference

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Direct restriction of virus release and incorporation of the interferon-induced protein BST-2 into HIV-1 particles

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

APOBEC3F and APOBEC3G inhibit HIV-1 DNA integration by different mechanisms.

8 July 2018

1 reference

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Strategies in designing multigene expression units to downregulate HIV-1.

8 July 2018

1 reference

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HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs.

8 July 2018

1 reference

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Hybrids of nonviral vectors for gene delivery

8 July 2018

1 reference

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Inhibition of HIV-1 infection by a unique short hairpin RNA to chemokine receptor 5 delivered into macrophages through hematopoietic progenitor cell transduction

8 July 2018

1 reference

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Anti-tetherin activities in Vpu-expressing primate lentiviruses

8 July 2018

1 reference

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Antagonism of CD317 restriction of human immunodeficiency virus type 1 (HIV-1) particle release and depletion of CD317 are separable activities of HIV-1 Vpu.

8 July 2018

1 reference

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Targeting HIV-1 DNA integration by swapping tethers

8 July 2018

1 reference

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Lentiviral vectors in gene therapy: their current status and future potential

8 July 2018

1 reference

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Immunoelectron microscopic evidence for Tetherin/BST2 as the physical bridge between HIV-1 virions and the plasma membrane

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration

8 July 2018

1 reference

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A transposon and transposase system for human application

8 July 2018

1 reference

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Vpu-dependent block to incorporation of GaLV Env into lentiviral vectors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics

8 July 2018

1 reference

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Recent advances in lentiviral vector development and applications

8 July 2018

1 reference

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Lentiviral vectors for immune cells targeting

8 July 2018

1 reference

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Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Anti-retroviral activity of TRIM5 alpha

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

High-level genomic integration, epigenetic changes, and expression of sleeping beauty transgene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Definition of the interacting interfaces of Apobec3G and HIV-1 Vif using MAPPIT mutagenesis analysis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Determinants for the rhesus monkey TRIM5alpha-mediated block of the late phase of HIV-1 replication

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Protection of stem cell-derived lymphocytes in a primate AIDS gene therapy model after in vivo selection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Cassette deletion in multiple shRNA lentiviral vectors for HIV-1 and its impact on treatment success

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Modification of integration site preferences of an HIV-1-based vector by expression of a novel synthetic protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Multiple ways of targeting APOBEC3-virion infectivity factor interactions for anti-HIV-1 drug development.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Foamy virus vectors for gene transfer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Foamy combinatorial anti-HIV vectors with MGMTP140K potently inhibit HIV-1 and SHIV replication and mediate selection in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Preintegration HIV-1 inhibition by a combination lentiviral vector containing a chimeric TRIM5 alpha protein, a CCR5 shRNA, and a TAR decoy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Specific transduction of HIV-susceptible cells for CCR5 knockdown and resistance to HIV infection: a novel method for targeted gene therapy and intracellular immunization.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Foamy and lentiviral vectors transduce canine long-term repopulating cells at similar efficiency

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Site-specific integration of retroviral DNA in human cells using fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc-finger protein E2C.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Impact of gene-modified T cells on HIV infection dynamics

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Homozygous and heterozygous CCR5-Delta32 genotypes are associated with resistance to HIV infection.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

An HIV-1 resistance polymorphism in TRIM5α gene among Chinese intravenous drug users

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Improvement of lentiviral vector-mediated gene transduction by genetic engineering of the structural protein Pr55 Gag.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

Chim3 confers survival advantage to CD4+ T cells upon HIV-1 infection by preventing HIV-1 DNA integration and HIV-1-induced G2 cell-cycle delay

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3095057

26 October 2018

Identifiers

DOI

10.1093/HMG/DDR160

1 reference

5 August 2017

1 reference

5 August 2017

1 reference