The chemical biology of apoptosis. Exploring protein-protein interactions and the life and death of cells with small molecules (Q34980881)

5 August 2017

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title

The chemical biology of apoptosis. Exploring protein-protein interactions and the life and death of cells with small molecules (English)

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protein-protein interaction

5 August 2017

main subject

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Ziwei Huang

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5 August 2017

publication date

1 October 2002

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5 August 2017

published in

Chemistry and Biology

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5 August 2017

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5 August 2017

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5 August 2017

page(s)

1059-1072

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Cell death: the significance of apoptosis

5 August 2017

cites work

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Caspases: enemies within

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7 January 2021

Mitochondria and apoptosis

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7 January 2021

Death receptors: signaling and modulation

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7 January 2021

Peptide and Protein Recognition by Designed Molecules

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7 January 2021

Protein-protein interfaces: mimics and inhibitors

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7 January 2021

The Bcl-2 protein family: arbiters of cell survival

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7 January 2021

BCL-2 family: regulators of cell death

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7 January 2021

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7 January 2021

Life-or-death decisions by the Bcl-2 protein family.

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7 January 2021

The biochemistry of apoptosis

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7 January 2021

The machinery of programmed cell death.

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7 January 2021

Biochemical pathways of caspase activation during apoptosis

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7 January 2021

Apoptosis in neurodegenerative disorders

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7 January 2021

Insights into programmed cell death through structural biology

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7 January 2021

A structural view of mitochondria-mediated apoptosis

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7 January 2021

Solution structure of the antiapoptotic protein bcl-2

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7 January 2021

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

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7 January 2021

Crystal structure of rat Bcl-xL. Implications for the function of the Bcl-2 protein family

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7 January 2021

Structure of Bax: coregulation of dimer formation and intracellular localization

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7 January 2021

Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

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7 January 2021

Solution structure of BID, an intracellular amplifier of apoptotic signaling

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7 January 2021

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

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7 January 2021

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

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7 January 2021

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

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7 January 2021

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

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7 January 2021

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

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7 January 2021

Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c rel

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7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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7 January 2021

Bcl-2-family proteins: the role of the BH3 domain in apoptosis

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7 January 2021

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

1 reference

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7 January 2021

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

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7 January 2021

Bad Is a BH3 Domain-Containing Protein That Forms an Inactivating Dimer with Bcl-XL

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7 January 2021

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

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7 January 2021

Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins

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7 January 2021

A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members

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7 January 2021

Regulation of apoptosis by BH3 domains in a cell-free system

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7 January 2021

Bax directly induces release of cytochrome c from isolated mitochondria

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7 January 2021

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

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7 January 2021

Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse

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7 January 2021

Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1

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7 January 2021

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

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7 January 2021

Selective inhibition of growth factor-stimulated mitogenesis by a cell-permeable Grb2-binding peptide

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7 January 2021

Inhibition of FGF-stimulated phosphatidylinositol hydrolysis and neurite outgrowth by a cell-membrane permeable phosphopeptide

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7 January 2021

Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases

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7 January 2021

Inhibition of IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat by a novel peptide inhibitor of protein kinase C.

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7 January 2021

A peptide-based protein-tyrosine phosphatase inhibitor specifically enhances insulin receptor function in intact cells

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7 January 2021

BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death

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7 January 2021

Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein

1 reference

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7 January 2021

Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent.

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7 January 2021

In vivo protein transduction: delivery of a biologically active protein into the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

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https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Structural chemistry and therapeutic intervention of protein-protein interactions in immune response, human immunodeficiency virus entry, and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

The Isolation and Properties of Antimycin A

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Structural factors of antimycin A molecule required for inhibitory action

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

A model of antimycin A binding based on structure-activity studies of synthetic antimycin A analogues

1 reference

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7 January 2021

Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix

1 reference

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7 January 2021

Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion

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https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Bcl-2 and the regulation of programmed cell death

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https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Bcl-2 family proteins as targets for anticancer drug design

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7 January 2021

Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1 reference

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7 January 2021

A matter of life and cell death

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7 January 2021

BCL-2 antisense therapy in patients with non-Hodgkin lymphoma

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7 January 2021

Life and death in paradise.

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7 January 2021

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

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https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

IAP family proteins--suppressors of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Understanding IAP function and regulation: a view from Drosophila

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7 January 2021

The molecular basis and potential role of survivin in cancer diagnosis and therapy

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https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Structural basis for phosphoserine-proline recognition by group IV WW domains

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Structural basis of caspase-7 inhibition by XIAP

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Structural basis for the inhibition of caspase-3 by XIAP

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Structural basis of IAP recognition by Smac/DIABLO

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Structural biology. Controlling the caspases

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https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

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https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

A conserved tetrapeptide motif: potentiating apoptosis through IAP-binding

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway

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https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Molecular targeting of inhibitor of apoptosis proteins based on small molecule mimics of natural binding partners

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis

1 reference

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7 January 2021

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

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https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900247-8

7 January 2021

10.1016/S1074-5521(02)00247-8

Identifiers

DOI

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5 August 2017

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