While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable. (Q34989253)

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21 December 2019

title

While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable (English)

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21 December 2019

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21 December 2019

Sarah J Plowman

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21 December 2019

D James Williamson

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21 December 2019

Maureen J O'Sullivan

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21 December 2019

Jennifer Doig

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21 December 2019

Ann-Marie Ritchie

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21 December 2019

David W Melton

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21 December 2019

Mark J Arends

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21 December 2019

Martin L Hooper

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21 December 2019

Charles E Patek

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21 December 2019

language of work or name

English

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publication date

1 December 2003

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Molecular and Cellular Biology

21 December 2019

published in

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21 December 2019

volume

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21 December 2019

issue

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21 December 2019

page(s)

9245-9250

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Ras proteins: different signals from different locations

21 December 2019

cites work

1 reference

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Mechanisms of Ras protein targeting in mammalian cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

Ras and relatives--job sharing and networking keep an old family together

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

SmgGDS displays differential binding and exchange activity towards different Ras isoforms

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

Prospects for anti-ras drugs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

Wildtype Kras2 can inhibit lung carcinogenesis in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

Blocking oncogenic Ras signaling for cancer therapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

Mutant K-ras enhances apoptosis in embryonic stem cells in combination with DNA damage and is associated with increased levels of p19(ARF).

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

Alternative splicing of the K-ras gene in mouse tissues and cell lines

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

Differential activation of the Rac pathway by Ha-Ras and K-Ras

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

The importance of being K-Ras

8 July 2018

1 reference

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Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

Developmentally-regulated expression of murine K-ras isoforms.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

K-ras is an essential gene in the mouse with partial functional overlap with N-ras

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

The murine N-ras gene is not essential for growth and development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

Polylysine domain of K-ras 4B protein is crucial for malignant transformation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

Structure and expression of amplified cKi-ras gene sequences in Y1 mouse adrenal tumor cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

A new mouse embryonic stem cell line with good germ line contribution and gene targeting frequency

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309700

The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene

8 July 2018

1 reference

12 December 2020

Mice deficient for N-ras: impaired antiviral immune response and T-cell function

1 reference

12 December 2020

K-ras modulates the cell cycle via both positive and negative regulatory pathways

1 reference

12 December 2020

K-ras is essential for the development of the mouse embryo

1 reference

12 December 2020

Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

1 reference

12 December 2020

10.1128/MCB.23.24.9245-9250.2003

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14645534%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

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21 December 2019

PubMed publication ID

14645534

1 reference

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