Flupirtine: pharmacology and clinical applications of a nonopioid analgesic and potentially neuroprotective compound. (Q34985534)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19505216%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

review article

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title

Flupirtine: pharmacology and clinical applications of a nonopioid analgesic and potentially neuroprotective compound (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19505216%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference

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30 January 2020

M Maschke

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30 January 2020

language of work or name

English

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publication date

1 June 2009

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Expert Opinion on Pharmacotherapy

30 January 2020

published in

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30 January 2020

volume

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30 January 2020

issue

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30 January 2020

page(s)

1495-1500

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Pyogenic infection and rheumatoid arthritis

30 January 2020

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Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist

21 January 2018

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Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels. Rapid communication.

21 January 2018

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Influence of flupirtine on a G‐protein coupled inwardly rectifying potassium current in hippocampal neurones

21 January 2018

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Substance P raises neuronal membrane excitability by reducing inward rectification

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M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals.

21 January 2018

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Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin, based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance.

21 January 2018

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Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity

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Retigabine: chemical synthesis to clinical application.

21 January 2018

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Investigation of the in vitro metabolism of the analgesic flupirtine

21 January 2018

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Pharmacokinetics of flupirtine in elderly volunteers and in patients with moderate renal impairment

21 January 2018

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Trial of oral flupirtine maleate in the treatment of pain after orthopaedic surgery

21 January 2018

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Antiparkinsonian and other motor effects of flupirtine alone and in combination with dopaminergic drugs

21 January 2018

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Effect of functional NMDA-antagonist flupirtine on automatic postural responses in Parkinson's disease

21 January 2018

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Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis

21 January 2018

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Retigabine and flupirtine exert neuroprotective actions in organotypic hippocampal cultures.

21 January 2018

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Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons

21 January 2018

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Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study

21 January 2018

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10.1517/14656560902988528

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19505216%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

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