Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages (Q34985249)

5 August 2017

title

Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages (English)

1 reference

5 August 2017

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Shimayama T

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5 August 2017

Nishikawa F

series ordinal

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5 August 2017

Nishikawa S

series ordinal

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5 August 2017

Taira K

series ordinal

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5 August 2017

language of work or name

English

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publication date

1 June 1993

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5 August 2017

published in

Nucleic Acids Research

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5 August 2017

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5 August 2017

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5 August 2017

page(s)

2605-2611

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Autolytic processing of dimeric plant virus satellite RNA

5 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Theoretical analyses on the role of Mg2+ ions in ribozyme reactions.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Metal ion catalysis in the Tetrahymena ribozyme reaction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Mutagenesis analysis of a self-cleaving RNA.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Self-cleavage of RNA in the replication of small pathogens of plants and animals

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Ribonuclease P: an enzyme with a catalytic RNA subunit

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Self-cleaving transcripts of satellite DNA from the newt

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Thiophosphate interference experiments locate phosphates important for the hammerhead RNA self-cleavage reaction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Mixed deoxyribo- and ribo-oligonucleotides with catalytic activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Ribozymes as potential anti-HIV-1 therapeutic agents.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Effects of phosphorothioate and 2-amino groups in hammerhead ribozymes on cleavage rates and Mg2+ binding

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Ribozymes that cleave an RNA sequence from human immunodeficiency virus: the effect of flanking sequence on rate

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Mutations in a nonconserved sequence of the Tetrahymena ribozyme increase activity and specificity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Novel route to oligo(deoxyribonucleoside phosphorothioates). Stereocontrolled synthesis of P-chiral oligo(deoxyribonucleoside phosphorothioates).

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Prevention of human immunodeficiency virus type 1 integrase expression in Escherichia coli by a ribozyme

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Preferential chelation of cationic ligands to axial-equatorial oxygens over equatorial-equatorial dianionic oxygens: implication to the mechanism of action of ribozymes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Evidence for processivity and two-step binding of the RNA substrate from studies of J1/2 mutants of the Tetrahymena ribozyme

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Function of specific 2'-hydroxyl groups of guanosines in a hammerhead ribozyme probed by 2' modifications

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Hammerhead ribozyme-mediated cleavage of the long terminal repeat RNA of human immunodeficiency virus type 1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Role of divalent metal ions in the hammerhead RNA cleavage reaction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Configurationally defined phosphorothioate-containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Mixed DNA/RNA polymers are cleaved by the hammerhead ribozyme

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Sequence requirements of the hammerhead RNA self-cleavage reaction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Substrate sequence effects on "hammerhead" RNA catalytic efficiency

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Minimal sequence requirements for ribozyme activity.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Numbering system for the hammerhead

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Nuclease resistant ribozymes with high catalytic activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Importance of specific purine amino and hydroxyl groups for efficient cleavage by a hammerhead ribozyme

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Inhibition of human immunodeficiency virus type 1 expression by a hairpin ribozyme

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

A ribozyme with DNA in the hybridising arms displays enhanced cleavage ability

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Simple RNA enzymes with new and highly specific endoribonuclease activities

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=309588

Substitution of non-catalytic stem and loop regions of hammerhead ribozyme with DNA counterparts only increases KM without sacrificing the catalytic step (kcat): a way to improve substrate-specificity

26 October 2018

1 reference

12 December 2020

Activities of HIV-RNA targeted ribozymes transcribed from a 'shot-gun' type ribozyme-trimming plasmid

1 reference

12 December 2020

Energetics of RNA cleavage: implications for the mechanism of action of ribozymes

1 reference

12 December 2020

Importance of specific adenosine N7-nitrogens for efficient cleavage by a hammerhead ribozyme. A model for magnesium binding

1 reference

12 December 2020

Kinetics of intermolecular cleavage by hammerhead ribozymes

1 reference

12 December 2020

Extended target-site specificity for a hammerhead ribozyme

1 reference

12 December 2020

Cleavage of specific sites of RNA by designed ribozymes

1 reference

12 December 2020

Relationship between 2'-hydroxyls and magnesium binding in the hammerhead RNA domain: a model for ribozyme catalysis

1 reference

12 December 2020

Studies on the hammerhead RNA self-cleaving domain

1 reference

12 December 2020

Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead Ribozymes

1 reference

12 December 2020

Construction of a series of several self-cleaving RNA duplexes using synthetic 21-mers

1 reference

12 December 2020

Study of a hammerhead ribozyme containing 2'-modified adenosine residues

1 reference

12 December 2020

RNA splicing in neurospora mitochondria: self-splicing of a mitochondrial intron in vitro

1 reference

12 December 2020

Minimum ribonucleotide requirement for catalysis by the RNA hammerhead domain

1 reference

12 December 2020

Structure and mechanism of the hammerhead self-cleaving domain

1 reference

12 December 2020

A small catalytic oligoribonucleotide

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/21.11.2605

1 reference

5 August 2017

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5 August 2017

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