Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses. (Q34979730)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25559258%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

title

Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25559258%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

main subject

T follicular helper cell

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25559258%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Sharad Shrestha

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25559258%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Kai Yang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25559258%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Cliff Guy

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25559258%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Peter Vogel

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25559258%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Geoffrey Neale

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25559258%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

language of work or name

English

0 references

publication date

5 January 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25559258%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

number of pages

1 reference

inferred from page(s)

published in

Nature Immunology

1 reference

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26 February 2020

volume

1 reference

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26 February 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25559258%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

page(s)

178-187

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25559258%20AND%20SRC:MED&resulttype=core&format=json

The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells

26 February 2020

cites work

1 reference

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FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability

8 July 2018

1 reference

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Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells

8 July 2018

1 reference

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Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming

8 July 2018

1 reference

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Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

MicroRNAs of the miR-17∼92 family are critical regulators of T(FH) differentiation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Novel Foxo1-dependent transcriptional programs control T(reg) cell function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Regulation and function of mTOR signalling in T cell fate decisions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Systemic elevation of PTEN induces a tumor-suppressive metabolic state

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Regulatory T cells: mechanisms of differentiation and function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Early Th1 cell differentiation is marked by a Tfh cell-like transition

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Regulation of immune responses by mTOR.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Foxp3+ follicular regulatory T cells control the germinal center response.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Follicular helper CD4 T cells (TFH)

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Stability of the regulatory T cell lineage in vivo.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Follicular helper T cells are required for systemic autoimmunity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297581

The plasticity and stability of regulatory T cells

8 July 2018

1 reference

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

21 January 2018

1 reference

Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches.

21 January 2018

1 reference

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

21 January 2018

1 reference

Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

21 January 2018

1 reference

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

21 January 2018

1 reference

Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice

21 January 2018

1 reference

Epigenetic modifications induced by Blimp-1 Regulate CD8⁺ T cell memory progression during acute virus infection

21 January 2018

1 reference

Cutting edge: Discrete functions of mTOR signaling in invariant NKT cell development and NKT17 fate decision.

21 January 2018

1 reference

Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25559258

12 December 2020

inferred from PubMed ID database lookup

Interferon-γ excess leads to pathogenic accumulation of follicular helper T cells and germinal centers

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25559258

12 December 2020

inferred from PubMed ID database lookup

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

1 reference

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NI.3076

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25559258%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25559258%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

PubMed publication ID

25559258

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25559258%20AND%20SRC:MED&resulttype=core&format=json