Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes (Q34959355)

5 August 2017

title

Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes (English)

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5 August 2017

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Nahum Sonenberg

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5 August 2017

Seyed Mehdi Jafarnejad

object named as

Seyed Mehdi Jafarnejad

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Christos G Gkogkas

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Ruifeng Cao

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Theodore J Price

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Jean-Claude Lacaille

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5 August 2017

Arkady Khoutorsky

1 reference

5 August 2017

Masha Prager-Khoutorsky

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5 August 2017

Nikolaos Giannakas

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5 August 2017

Archontia Kaminari

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5 August 2017

Apostolia Fragkouli

1 reference

5 August 2017

Karim Nader

1 reference

5 August 2017

Bruce W Konicek

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5 August 2017

Jeremy R Graff

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5 August 2017

Athina K Tzinia

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5 August 2017

publication date

26 November 2014

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5 August 2017

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5 August 2017

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5 August 2017

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5 August 2017

page(s)

1742-1755

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Genetic removal of matrix metalloproteinase 9 rescues the symptoms of fragile X syndrome in a mouse model

5 August 2017

cites work

1 reference

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Fragile X mental retardation protein regulates translation by binding directly to the ribosome

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Control of synaptic plasticity and memory via suppression of poly(A)-binding protein

8 July 2018

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A randomized double-blind, placebo-controlled trial of minocycline in children and adolescents with fragile x syndrome

8 July 2018

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Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome

8 July 2018

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Exaggerated translation causes synaptic and behavioural aberrations associated with autism

8 July 2018

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FMRP targets distinct mRNA sequence elements to regulate protein expression

8 July 2018

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8 July 2018

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Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice

8 July 2018

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8 July 2018

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8 July 2018

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Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome

8 July 2018

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8 July 2018

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FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism

8 July 2018

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Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation

8 July 2018

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eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

8 July 2018

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8 July 2018

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Dysregulation of mTOR signaling in fragile X syndrome

8 July 2018

1 reference

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The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases).

8 July 2018

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In vivo roles for matrix metalloproteinase-9 in mature hippocampal synaptic physiology and plasticity

8 July 2018

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Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome

8 July 2018

1 reference

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Upstream and downstream of mTOR

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294557

The mGluR theory of fragile X mental retardation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294557

Translational control by MAPK signaling in long-term synaptic plasticity and memory

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294557

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294557

Genetic analysis of audiogenic seizure susceptibility in C57BL/6J X DBA/2J recombinant inbred strains of mice

8 July 2018

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Adult fragile X syndrome. Clinico-neuropathologic findings

8 July 2018

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Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

8 July 2018

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8 July 2018

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The Fragile X mental retardation protein regulates matrix metalloproteinase 9 mRNA at synapses

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294557

Long-lasting effects of minocycline on behavior in young but not adult Fragile X mice

26 October 2018

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26 October 2018

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Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome

26 October 2018

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Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of Fragile X Syndrome

26 October 2018

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Enhanced neuronal plasticity and elevated endogenous sAPPα levels in mice over-expressing MMP9.

26 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294557

Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294557

SUnSET, a nonradioactive method to monitor protein synthesis.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294557

Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294557

Audiogenic seizure susceptibility is reduced in fragile X knockout mice after introduction of FMR1 transgenes

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294557

Dendritic spine abnormalities in the occipital cortex of C57BL/6 Fmr1 knockout mice.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294557

NMDA receptor activation results in PKA- and ERK-dependent Mnk1 activation and increased eIF4E phosphorylation in hippocampal area CA1.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294557

Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4294557

Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch-Belgian Fragile X Consortium

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25466251

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25466251

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

High MMP-9 activity levels in fragile X syndrome are lowered by minocycline

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25466251

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELREP.2014.10.064

1 reference

5 August 2017

1 reference

5 August 2017

1 reference