Engineering the proteolytic specificity of activated protein C improves its pharmacological properties (Q34956516)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12671072%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

title

Engineering the proteolytic specificity of activated protein C improves its pharmacological properties (English)

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2 November 2019

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2 November 2019

David T Berg

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2 November 2019

Bruce Gerlitz

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2 November 2019

Jing Shang

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2 November 2019

Tommy Smith

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2 November 2019

Paula Santa

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2 November 2019

Mark A Richardson

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2 November 2019

Ken D Kurz

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2 November 2019

Brian W Grinnell

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2 November 2019

Ken Mace

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2 November 2019

language of work or name

English

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publication date

1 April 2003

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Proceedings of the National Academy of Sciences of the United States of America

2 November 2019

published in

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2 November 2019

volume

100

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2 November 2019

issue

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2 November 2019

page(s)

4423-4428

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Efficacy and safety of recombinant human activated protein C for severe sepsis

2 November 2019

cites work

1 reference

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Engineering enzyme specificity.

8 July 2018

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Regulation of the serine proteinase inhibitor (SERPIN) gene alpha 1-antitrypsin: a paradigm for other SERPINs

8 July 2018

1 reference

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An atlas of serpin conformations.

8 July 2018

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Evolutionary Divergence of Substrate Specificity within the Chymotrypsin-like Serine Protease Fold

8 July 2018

1 reference

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Pharmacological characterization of desensitization in a human mGlu1 alpha-expressing non-neuronal cell line co-transfected with a glutamate transporter

8 July 2018

1 reference

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The 2.8 A crystal structure of Gla-domainless activated protein C

8 July 2018

1 reference

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Role of residue 99 at the S2 subsite of factor Xa and activated protein C in enzyme specificity

8 July 2018

1 reference

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FACS-optimized mutants of the green fluorescent protein (GFP)

8 July 2018

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General features of the heparin-binding serpins antithrombin, heparin cofactor II and protein C inhibitor

8 July 2018

1 reference

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High-level expression of secreted proteins from cells adapted to serum-free suspension culture.

8 July 2018

1 reference

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Interaction of activated protein C with serpins

8 July 2018

1 reference

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A faster-acting and more potent form of tissue plasminogen activator

8 July 2018

1 reference

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Resistance to inhibition by alpha-1-anti-trypsin and species specificity of a chimeric human/bovine protein C.

8 July 2018

1 reference

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The mechanism of inactivation of human factor V and human factor Va by activated protein C

8 July 2018

1 reference

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Structural basis of substrate specificity in the serine proteases

8 July 2018

1 reference

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Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function

8 July 2018

1 reference

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Protein C inhibitor. Purification from human plasma and characterization

8 July 2018

1 reference

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On the size of the active site in proteases. I. Papain

8 July 2018

1 reference

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

8 July 2018

1 reference

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Physiologic inhibition of human activated protein C by alpha 1-antitrypsin

8 July 2018

1 reference

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Serpin-resistant mutants of human tissue-type plasminogen activator

8 July 2018

1 reference

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Inhibition of activated protein C by recombinant alpha 1-antitrypsin variants with substitution of arginine or leucine for methionine358.

8 July 2018

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Amino acid residues that affect interaction of tissue-type plasminogen activator with plasminogen activator inhibitor 1

8 July 2018

1 reference

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The novel mechanism of initiation of picornavirus RNA translation

8 July 2018

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Glycosylation of human protein C affects its secretion, processing, functional activities, and activation by thrombin

8 July 2018

1 reference

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Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C concentrate

8 July 2018

1 reference

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Direct detection of activated protein C in blood from human subjects

8 July 2018

1 reference

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Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors

8 July 2018

1 reference

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E1a-responsive mammalian host/vector system for the stable high-level expression of secreted proteins

8 July 2018

1 reference

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The protein C anticoagulant pathway

8 July 2018

1 reference

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Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis

8 July 2018

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CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

21 January 2018

1 reference

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Tracking structural features leading to resistance of activated protein C to alpha 1-antitrypsin

21 January 2018

1 reference

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Inherited protein C deficiency and coumarin-responsive chronic relapsing purpura fulminans in a newborn infant

21 January 2018

1 reference

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Homozygous protein C deficiency manifested by massive venous thrombosis in the newborn

21 January 2018

1 reference

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Congenital protein C deficiency and venous thromboembolism. A study of three Dutch families

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0736918100

Redesigning trypsin: alteration of substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0736918100

Molecular basis of residue 192 participation in determination of coagulation protease specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0736918100

Mutation of protease domain residues Lys37-39 in human protein C inhibits activation by the thrombomodulin-thrombin complex without affecting activation by free thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0736918100

Treatment of patients with disseminated intravascular coagulation by protein C

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0736918100

A slow clearing, fibrin-specific, PAI-1 resistant variant of t-PA (T103N, KHRR 296-299 AAAA)

21 January 2018

1 reference

12 December 2020

A variant of t-PA (T103N, KHRR 296-299 AAAA) that, by bolus, has increased potency and decreased systemic activation of plasminogen

1 reference

12 December 2020

An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia

1 reference

12 December 2020

Effect of protein C and activated protein C on coagulation and fibrinolysis in normal human subjects

1 reference

12 December 2020

Activation of protein C and its distribution between its inhibitors, protein C inhibitor, alpha 1-antitrypsin and alpha 2-macroglobulin, in patients with disseminated intravascular coagulation

1 reference

12 December 2020

Serum alpha-1-antitrypsin in ischemia and rheumatic heart diseases

1 reference

12 December 2020

The protein C pathway: new insights

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0736918100

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12671072%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

0 references

1 reference

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2 November 2019

PubMed publication ID

12671072

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12671072%20AND%20SRC:MED&resulttype=core&format=json