Chronic treatment with a novel γ-secretase modulator, JNJ-40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer's disease. (Q34919663)

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English	Chronic treatment with a novel γ-secretase modulator, JNJ-40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer's disease.	scientific article

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20 January 2020

Chronic treatment with a novel γ-secretase modulator, JNJ-40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer's disease (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21232036%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Alzheimer's disease

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5

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20 January 2020

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B Van Broeck

1

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20 January 2020

J-M Chen

2

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20 January 2020

G Tréton

3

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20 January 2020

M Desmidt

4

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20 January 2020

N Ramsden

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20 January 2020

E Karran

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20 January 2020

M Mercken

8

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20 January 2020

A Rowley

9

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20 January 2020

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1 May 2011

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20 January 2020

British Journal of Pharmacology

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20 January 2020

163

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20 January 2020

2

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20 January 2020

375-389

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20 January 2020

Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease

1 reference

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8 July 2018

Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process

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8 July 2018

Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial

1 reference

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8 July 2018

Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase

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8 July 2018

Gamma-secretase modulation and its promise for Alzheimer's disease: a medicinal chemistry perspective

1 reference

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8 July 2018

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation

1 reference

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8 July 2018

1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.

1 reference

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8 July 2018

Evidence that Perutz's double-beta-stranded subunit structure for beta-amyloids also applies to their channel-forming structures in membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087138

8 July 2018

gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087138

8 July 2018

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087138

8 July 2018

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

1 reference

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8 July 2018

Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087138

8 July 2018

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087138

8 July 2018

Novel aspects of accumulation dynamics and A beta composition in transgenic models of AD.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087138

8 July 2018

Alzheimer disease: mechanistic understanding predicts novel therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087138

8 July 2018

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087138

8 July 2018

Modulation of beta-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087138

8 July 2018

Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor

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8 July 2018

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087138

8 July 2018

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087138

8 July 2018

Characterization of amyloid beta peptides from brain extracts of transgenic mice overexpressing the London mutant of human amyloid precursor protein

1 reference

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8 July 2018

Selective inhibition of Abeta42 production by NSAID R-enantiomers

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8 July 2018

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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8 July 2018

beta-amyloid deposits in transgenic mice expressing human beta-amyloid precursor protein have the same characteristics as those in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087138

8 July 2018

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

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8 July 2018

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

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8 July 2018

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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8 July 2018

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

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8 July 2018

Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations

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https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01207.X

21 January 2018

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

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21 January 2018

CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01207.X

21 January 2018

The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent

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21 January 2018

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

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21 January 2018

Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01207.X

21 January 2018

Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

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26 October 2018

Gamma -secretase inhibitors repress thymocyte development

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12 December 2020

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Clinical endoscopic evaluation of the gastroduodenal tolerance to (R)- ketoprofen, (R)- flurbiprofen, racemic ketoprofen, and paracetamol: a randomized, single-blind, placebo-controlled trial

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https://pubmed.ncbi.nlm.nih.gov/21232036

12 December 2020

based on heuristic

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10.1111/J.1476-5381.2011.01207.X

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20 January 2020

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Europe PubMed Central

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20 January 2020

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20 January 2020

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