To DRiP or not to DRiP: generating peptide ligands for MHC class I molecules from biosynthesized proteins (Q34801788)

4 August 2017

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title

To DRiP or not to DRiP: generating peptide ligands for MHC class I molecules from biosynthesized proteins (English)

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4 August 2017

Jonathan Yewdell

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4 August 2017

publication date

1 October 2002

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4 August 2017

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4 August 2017

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4 August 2017

issue

3-4

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4 August 2017

page(s)

139-146

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Intracellular localization of proteasomal degradation of a viral antigen

4 August 2017

cites work

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7 January 2021

Introduction of a glycosylation site into a secreted protein provides evidence for an alternative antigen processing pathway: transport of precursors of major histocompatibility complex class I-restricted peptides from the endoplasmic reticulum to t

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7 January 2021

Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions

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7 January 2021

The unfolding of substrates and ubiquitin-independent protein degradation by proteasomes

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7 January 2021

gamma-Interferon decreases the level of 26 S proteasomes and changes the pattern of phosphorylation

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7 January 2021

ER protein quality control and proteasome-mediated protein degradation

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7 January 2021

Subcellular localization of proteasomes and their regulatory complexes in mammalian cells.

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7 January 2021

Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance

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7 January 2021

The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells

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7 January 2021

A novel influenza A virus mitochondrial protein that induces cell death.

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7 January 2021

Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens.

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7 January 2021

Regulation of cellular polyamines by antizyme

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7 January 2021

Expression of a membrane protease enhances presentation of endogenous antigens to MHC class I-restricted T lymphocytes

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7 January 2021

Subcellular distribution of proteasomes implicates a major location of protein degradation in the nuclear envelope-ER network in yeast

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7 January 2021

Efficient MHC class I-independent amino-terminal trimming of epitope precursor peptides in the endoplasmic reticulum

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7 January 2021

Folding of newly translated proteins in vivo: the role of molecular chaperones

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7 January 2021

A proteolytic system that compensates for loss of proteasome function

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7 January 2021

Functional analysis of the proteasome regulatory particle

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7 January 2021

Proteasomal degradation of Smad1 induced by bone morphogenetic proteins

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7 January 2021

Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome

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7 January 2021

CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation

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7 January 2021

Aggresomes: a cellular response to misfolded proteins

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7 January 2021

The transporter associated with antigen processing: function and implications in human diseases

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7 January 2021

Proteasome inhibitors: valuable new tools for cell biologists

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7 January 2021

Roles of heat-shock proteins in antigen presentation and cross-presentation

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7 January 2021

Protein-splicing intein: Genetic mobility, origin, and evolution

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7 January 2021

Review: properties and assembly mechanisms of ND10, PML bodies, or PODs

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7 January 2021

Non-traditionally derived CTL epitopes: exceptions that prove the rules?

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7 January 2021

A role for the ubiquitin-dependent proteolytic pathway in MHC class I-restricted antigen presentation

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7 January 2021

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

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7 January 2021

Generation and TAP-mediated transport of peptides for major histocompatibility complex class I molecules.

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7 January 2021

Identification of a fourth class of proteins linked to the murine major histocompatibility complex

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7 January 2021

Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells

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7 January 2021

The Class I Antigen-processing Pathway for the Membrane Protein Tyrosinase Involves Translation in the Endoplasmic Reticulum and Processing in the Cytosol

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7 January 2021

Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta.

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https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900097-4

7 January 2021

Protein splicing and related forms of protein autoprocessing

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https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900097-4

7 January 2021

Impaired immunoproteasome assembly and immune responses in PA28-/- mice.

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7 January 2021

The proteasome activator 11 S REG (PA28) and class I antigen presentation

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7 January 2021

The major substrates for TAP in vivo are derived from newly synthesized proteins

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7 January 2021

Dynamics of proteasome distribution in living cells

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7 January 2021

Regulation of proteasome complexes by gamma-interferon and phosphorylation

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7 January 2021

Degradation of cell proteins and the generation of MHC class I-presented peptides

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7 January 2021

Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase

1 reference

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900097-4

1 reference

7 January 2021

The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic doses

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https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900097-4

7 January 2021

Heat shock proteins transfer peptides during antigen processing and CTL priming

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7 January 2021

Nuclear dots: Actors on Many Stages

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7 January 2021

The MHC class I ligand-generating system: roles of immunoproteasomes and the interferon-gamma-inducible proteasome activator PA28.

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https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900097-4

7 January 2021

Recognition of the polyubiquitin proteolytic signal

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https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900097-4

7 January 2021

T cell-recognized antigenic peptides derived from the cellular genome are not protein degradation products but can be generated directly by transcription and translation of short subgenic regions. A hypothesis

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https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900097-4

7 January 2021

Efficiency of MHC class I antigen processing: a quantitative analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900097-4

7 January 2021

The 26S proteasome: a molecular machine designed for controlled proteolysis

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https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900097-4

7 January 2021

Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900097-4

7 January 2021

Costimulation in antiviral immunity: differential requirements for CD4(+) and CD8(+) T cell responses

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900097-4

7 January 2021

Localization of the 26S proteasome during mitosis and meiosis in fission yeast

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https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900097-4

7 January 2021

Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome

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https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900097-4

7 January 2021

Not such a dismal science: the economics of protein synthesis, folding, degradation and antigen processing

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https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900097-4

7 January 2021

Mechanisms of exogenous antigen presentation by MHC class I molecules in vitro and in vivo: implications for generating CD8+ T cell responses to infectious agents, tumors, transplants, and vaccines

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900097-4

7 January 2021

Cytotoxic T cells to type A influenza virus; viral hemagglutinin induces A-strain specificity while infected cells confer cross-reactive cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0161-5890%2802%2900097-4

7 January 2021

10.1016/S0161-5890(02)00097-4

Identifiers

DOI

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4 August 2017

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