Thrombospondin 1 is a key mediator of transforming growth factor β-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism (Q34797834)

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scientific article published on March 31, 2011

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English	Thrombospondin 1 is a key mediator of transforming growth factor β-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism	scientific article published on March 31, 2011

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 August 2017

Thrombospondin 1 is a key mediator of transforming growth factor β-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

corrigendum / erratum

Erratum to: Thrombospondin 1 is a key mediator of transforming growth factor b-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism

1 reference

10.1186/S13069-015-0021-1

12 July 2019

http://api.crossref.org/works?select=update-to&filter=doi:10.1186/S13069-015-0021-1

author name string

Yunliang Chen

1

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Europe PubMed Central

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4 August 2017

Andrew Leask

2

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4 August 2017

Laura Kennedy

4

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Europe PubMed Central

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4 August 2017

Xu Shi-Wen

5

1 reference

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4 August 2017

Mark Eastwood

9

1 reference

Europe PubMed Central

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4 August 2017

David J. Abraham

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21453480

28 November 2024

Christopher P. Denton

6

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Europe PubMed Central

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28 November 2024

Carol M. Black

7

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28 November 2024

Liaquat S. Verjee

8

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28 November 2024

language of work or name

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National Center for Biotechnology Information

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21453480

28 November 2024

publication date

31 March 2011

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4 August 2017

full work available at URL

https://fibrogenesis.biomedcentral.com/track/pdf/10.1186/1755-1536-4-9

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28 November 2024

https://europepmc.org/articles/PMC3077328

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Europe PubMed Central

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21453480

28 November 2024

https://europepmc.org/articles/PMC3077328?pdf=render

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online access status

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Europe PubMed Central

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21453480

28 November 2024

https://link.springer.com/content/pdf/10.1186/1755-1536-4-9.pdf

Portable Document Format

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10.1186/1755-1536-4-9

https://api.crossref.org/works/10.1186/1755-1536-4-9

28 November 2024

Fibrogenesis and Tissue Repair

1 reference

Europe PubMed Central

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4 August 2017

4

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Europe PubMed Central

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4 August 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Systemic sclerosis: a prototypic multisystem fibrotic disorder

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

The role of syndecans in disease and wound healing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Mechanisms and consequences of fibrosis in systemic sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Scar wars: is TGFbeta the phantom menace in scleroderma?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Integrin-dependent actomyosin contraction regulates epithelial cell scattering.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Constitutive thrombospondin-1 overexpression contributes to autocrine transforming growth factor-beta signaling in cultured scleroderma fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblasts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

The role of thrombospondin-1 in human disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

TGF-beta signaling and the fibrotic response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

The role of thrombospondins 1 and 2 in the regulation of cell-matrix interactions, collagen fibril formation, and the response to injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

The fibroblast-populated collagen matrix as a model of wound healing: a review of the evidence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Fibroblast biology in three-dimensional collagen matrices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Thrombospondin-1 promotes proliferative healing through stabilization of PDGF.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Myofibroblasts and mechano-regulation of connective tissue remodelling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Fibroblast-collagen-matrix contraction: growth-factor signalling and mechanical loading

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Thrombospondin-1 is a major activator of TGF-beta1 in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Quantitative analysis of collagen gel contractile forces generated by dermal fibroblasts and the relationship to cell morphology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Activation of dermal connective tissue in scleroderma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

8 July 2018

Thrombospondin-1 differentially induces chemotaxis and DNA synthesis of human venous smooth muscle cells at the receptor-binding level

1 reference

https://api.crossref.org/works/10.1186%2F1755-1536-4-9

21 January 2018

CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts

1 reference

https://api.crossref.org/works/10.1186%2F1755-1536-4-9

21 January 2018

Effect of precise mechanical loading on fibroblast populated collagen lattices: morphological changes

1 reference

https://api.crossref.org/works/10.1186%2F1755-1536-4-9

21 January 2018

CCN2 is necessary for the function of mouse embryonic fibroblasts.

1 reference

https://api.crossref.org/works/10.1186%2F1755-1536-4-9

21 January 2018

Amino acids induce indicators of response to injury in glomerular mesangial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

26 October 2018

Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077328

26 October 2018

Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/21453480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated pro alpha 2(I) collagen mRNA levels in cultured scleroderma fibroblasts result from an increased transcription rate of the corresponding gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/21453480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A culture force monitor for measurement of contraction forces generated in human dermal fibroblast cultures: evidence for cell-matrix mechanical signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/21453480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/21453480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta 1 integrin- and proteoglycan-mediated stimulation of T lymphoma cell adhesion and mitogen-activated protein kinase signaling by thrombospondin-1 and thrombospondin-1 peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/21453480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanical loading regulates protease production by fibroblasts in three-dimensional collagen substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/21453480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombospondin-1 promotes fibroblast-mediated collagen gel contraction caused by activation of latent transforming growth factor beta-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/21453480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon-{beta} inhibits bleomycin-induced lung fibrosis by decreasing transforming growth factor-{beta} and thrombospondin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21453480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/21453480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of primary fibroblasts and keratinocytes with extracellular matrix proteins: contribution of alpha2beta1 integrin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21453480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Scleroderma (systemic sclerosis): classification, subsets and pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21453480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanical loading and TGF-beta regulate proteoglycan synthesis in tendon

1 reference

https://pubmed.ncbi.nlm.nih.gov/21453480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of connective tissue growth factor mRNA in the fibrous stroma of mammary tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21453480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Journal of Rheumatology

21

15

202

author name string

EC LeRoy

publication date

1988

1 reference

10.1186/1755-1536-4-9

https://api.crossref.org/works/10.1186/1755-1536-4-9

28 November 2024

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10.1186/1755-1536-4-9

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Europe PubMed Central

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4 August 2017

Dimensions Publication ID

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

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