Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin (Q34785784)

4 August 2017

title

Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin (English)

1 reference

4 August 2017

1 reference

Hugh S Gannon

1 reference

4 August 2017

Lawrence A Donehower

series ordinal

1 reference

4 August 2017

Stephen Lyle

series ordinal

1 reference

4 August 2017

Stephen N Jones

series ordinal

1 reference

4 August 2017

language of work or name

English

0 references

publication date

17 February 2011

1 reference

4 August 2017

1 reference

inferred from page(s)

published in

Developmental Biology

1 reference

4 August 2017

volume

353

1 reference

4 August 2017

1 reference

4 August 2017

page(s)

1-9

1 reference

TAp63 induces senescence and suppresses tumorigenesis in vivo

4 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Isolation and culture of epithelial stem cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Two faces of p53: aging and tumor suppression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Modeling the therapeutic efficacy of p53 restoration in tumors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Lhx2 maintains stem cell character in hair follicles

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Unleashing the power of p53: lessons from mice and men.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Tumor suppression and normal aging in mice with constitutively high p53 activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Modulation of mammalian life span by the short isoform of p53.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Defining the epithelial stem cell niche in skin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Live or let die: the cell's response to p53

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Assessing TP53 status in human tumours to evaluate clinical outcome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Molecular mechanisms of skin ageing

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

p53 mutant mice that display early ageing-associated phenotypes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Controls of hair follicle cycling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Regulation of p53 stability by Mdm2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Mdm2 promotes the rapid degradation of p53

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

p16INK4A is a robust in vivo biomarker of cellular aging in human skin.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Complicating the role of p53 in aging.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

In utero activation of K5.CrePR1 induces gene deletion

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Hdmx and Mdm2 can repress transcription activation by p53 but not by p63.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

The MDM2 RING-finger domain is required to promote p53 nuclear export

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

Alterations in cell cycle regulation in mouse skin tumors.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075331

p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis

26 October 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.02.007

Highly persistent label-retaining cells in the hair follicles of mice and their fate following induction of anagen

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.02.007

Involvement of follicular stem cells in forming not only the follicle but also the epidermis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.02.007

Aging and p53: getting it straight. A commentary on a recent paper by Gentry and Venkatachalam

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.02.007

MDM2 and MDMX can interact differently with ARF and members of the p53 family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2011.02.007

Generation of an Mdm2 conditional allele in mice

7 January 2021

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21334322

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.YDBIO.2011.02.007

1 reference

4 August 2017

1 reference

4 August 2017

1 reference