A sensitive assay using a native protein substrate for screening HIV-1 maturation inhibitors targeting the protease cleavage site between the matrix and capsid (Q34771244)

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English	A sensitive assay using a native protein substrate for screening HIV-1 maturation inhibitors targeting the protease cleavage site between the matrix and capsid	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 August 2017

A sensitive assay using a native protein substrate for screening HIV-1 maturation inhibitors targeting the protease cleavage site between the matrix and capsid (English)

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4 August 2017

Ronald Swanstrom

7

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Ronald Swanstrom

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4 August 2017

author name string

Sook-Kyung Lee

1

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4 August 2017

Nancy Cheng

2

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4 August 2017

Emily Hull-Ryde

3

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4 August 2017

Marc Potempa

4

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4 August 2017

Celia A Schiffer

5

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4 August 2017

William Janzen

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4 August 2017

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publication date

11 July 2013

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4 August 2017

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4 August 2017

52

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4 August 2017

29

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Europe PubMed Central

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4 August 2017

4929-4940

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4 August 2017

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3855639/fullTextXML

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Mutations in multiple domains of Gag drive the emergence of in vitro resistance to the phosphonate-containing HIV-1 protease inhibitor GS-8374.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855639

7 July 2018

HIV-1 assembly, budding, and maturation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855639

7 July 2018

Structure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855639

7 July 2018

Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855639

7 July 2018

Context surrounding processing sites is crucial in determining cleavage rate of a subset of processing sites in HIV-1 Gag and Gag-Pro-Pol polyprotein precursors by viral protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855639

7 July 2018

The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855639

7 July 2018

HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855639

7 July 2018

Three Residues in HIV-1 Matrix Contribute to Protease Inhibitor Susceptibility and Replication Capacity

1 reference

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7 July 2018

HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice

1 reference

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7 July 2018

Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men

1 reference

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7 July 2018

Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization

1 reference

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7 July 2018

Phenotypic susceptibility to bevirimat in isolates from HIV-1-infected patients without prior exposure to bevirimat

1 reference

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7 July 2018

High prevalence of bevirimat resistance mutations in protease inhibitor-resistant HIV isolates

1 reference

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7 July 2018

HIV-1 Gag processing intermediates trans-dominantly interfere with HIV-1 infectivity.

1 reference

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7 July 2018

Structure and assembly of immature HIV

1 reference

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7 July 2018

A strongly transdominant mutation in the human immunodeficiency virus type 1 gag gene defines an Achilles heel in the virus life cycle

1 reference

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7 July 2018

Three-dimensional analysis of budding sites and released virus suggests a revised model for HIV-1 morphogenesis

1 reference

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7 July 2018

Resilience to resistance of HIV-1 protease inhibitors: profile of darunavir.

1 reference

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7 July 2018

Visualization of a proteasome-independent intermediate during restriction of HIV-1 by rhesus TRIM5alpha

1 reference

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7 July 2018

Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein

1 reference

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7 July 2018

3-O-(3',3'-dimethysuccinyl) betulinic acid inhibits maturation of the human immunodeficiency virus type 1 Gag precursor assembled in vitro

1 reference

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7 July 2018

Mutant murine leukemia virus Gag proteins lacking proline at the N-terminus of the capsid domain block infectivity in virions containing wild-type Gag.

1 reference

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7 July 2018

The Mechanism of HIV-1 Core Assembly: Insights from Three-Dimensional Reconstructions of Authentic Virions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855639

7 July 2018

Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855639

7 July 2018

A peptide inhibitor of HIV-1 assembly in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855639

7 July 2018

Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor

1 reference

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7 July 2018

High-resolution structure of a retroviral capsid hexameric amino-terminal domain

1 reference

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7 July 2018

The prevalence of antiretroviral drug resistance in the United States

1 reference

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Polarization of the fluorescence of macromolecules. I. Theory and experimental method

1 reference

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7 July 2018

Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation

1 reference

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7 July 2018

PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855639

7 July 2018

Functional Surfaces of the Human Immunodeficiency Virus Type 1 Capsid Protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855639

7 July 2018

Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population

1 reference

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7 July 2018

X-ray crystallographic structure of ABT-378 (lopinavir) bound to HIV-1 protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855639

7 July 2018

Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyprotein

1 reference

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7 July 2018

Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy.

1 reference

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7 July 2018

Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease

1 reference

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1 reference

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Specific covalent labeling of recombinant protein molecules inside live cells

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Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assembly

1 reference

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Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents

1 reference

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7 July 2018

A synthetic peptide from HIV-1 gp41 is a potent inhibitor of virus-mediated cell-cell fusion

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Assay of proteolytic enzymes by the fluorescence polarization technique

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Antiviral inhibition of the HIV-1 capsid protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3855639

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1 reference

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Measurement of specific protease activity utilizing fluorescence polarization

1 reference

https://pubmed.ncbi.nlm.nih.gov/23763575

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/23763575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI4005232

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

ResearchGate publication ID

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