Concurrent activation of liver X receptor and peroxisome proliferator-activated receptor alpha exacerbates hepatic steatosis in high fat diet-induced obese mice (Q34770055)

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English	Concurrent activation of liver X receptor and peroxisome proliferator-activated receptor alpha exacerbates hepatic steatosis in high fat diet-induced obese mice	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 August 2017

Concurrent activation of liver X receptor and peroxisome proliferator-activated receptor alpha exacerbates hepatic steatosis in high fat diet-induced obese mice (English)

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Europe PubMed Central

PubMed publication ID

4 August 2017

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Mingming Gao

1

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Europe PubMed Central

PubMed publication ID

4 August 2017

Le Bu

2

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Europe PubMed Central

PubMed publication ID

4 August 2017

Yongjie Ma

3

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Europe PubMed Central

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4 August 2017

Dexi Liu

4

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Europe PubMed Central

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4 August 2017

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publication date

7 June 2013

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Europe PubMed Central

PubMed publication ID

4 August 2017

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Europe PubMed Central

PubMed publication ID

4 August 2017

8

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Europe PubMed Central

PubMed publication ID

4 August 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

e65641

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Europe PubMed Central

PubMed publication ID

4 August 2017

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Creative Commons Attribution 4.0 International

7 June 2013

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April 2022 Public Data File from Crossref

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Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 corepressor complex in mice

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7 July 2018

A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα.

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7 July 2018

Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity

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Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.

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7 July 2018

Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites

1 reference

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7 July 2018

Liver x receptors in atherosclerosis and inflammation

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Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity

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Liver X receptor (LXR) regulates human adipocyte lipolysis

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Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis, and elongation in mice

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The role of PPARalpha in lipid metabolism and obesity: focusing on the effects of estrogen on PPARalpha actions

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Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose PPARalpha in high fat diet-induced obese mice

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7 July 2018

Biological role of liver X receptors.

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7 July 2018

AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency

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7 July 2018

Fenofibrate: treatment of hyperlipidemia and beyond

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Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia

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7 July 2018

PPARalpha in atherosclerosis and inflammation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3676322

7 July 2018

PPARalpha is a key regulator of hepatic FGF21.

1 reference

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7 July 2018

Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

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7 July 2018

Liver X receptor preferentially activates de novo lipogenesis in human preadipocytes

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3676322

7 July 2018

Fenofibrate prevents Rosiglitazone-induced body weight gain in ob/ob mice.

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7 July 2018

Ligand-binding regulation of LXR/RXR and LXR/PPAR heterodimerizations: SPR technology-based kinetic analysis correlated with molecular dynamics simulation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3676322

7 July 2018

PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3676322

7 July 2018

The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3676322

7 July 2018

https://pubmed.ncbi.nlm.nih.gov/23762402

12 December 2020

based on heuristic

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Brown adipose tissue: function and physiological significance

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3676322

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Obesity is associated with macrophage accumulation in adipose tissue

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3676322

7 July 2018

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling

1 reference

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Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

1 reference

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On the role of liver X receptors in lipid accumulation in adipocytes

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Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

1 reference

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Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism

1 reference

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Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles

1 reference

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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A potent PPARalpha agonist stimulates mitochondrial fatty acid beta-oxidation in liver and skeletal muscle

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Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting

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Lipid extraction of tissues with a low-toxicity solvent

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Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of L

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0065641

21 January 2018

Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0065641

21 January 2018

The liver X receptor agonist T0901317 protects mice from high fat diet-induced obesity and insulin resistance

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0065641

21 January 2018

Liver X receptor agonists ameliorate TNFalpha-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0065641

21 January 2018

The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0065641

21 January 2018

Peroxisome proliferator-activated receptor-α agonist, Wy 14,643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0065641

21 January 2018

Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0065641

21 January 2018

SREBP-1-independent regulation of lipogenic gene expression in adipocytes.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0065641

21 January 2018

Intestine-specific regulation of PPARalpha gene transcription by liver X receptors

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0065641

21 January 2018

The RXR agonist LG100268 causes hepatomegaly, improves glycaemic control and decreases cardiovascular risk and cachexia in diabetic mice suffering from pancreatic beta-cell dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/23762402

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR

1 reference

https://pubmed.ncbi.nlm.nih.gov/23762402

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0065641

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

2013PLoSO...865641G

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

ResearchGate publication ID

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