Down-regulation of methylthioadenosine phosphorylase (MTAP) induces progression of hepatocellular carcinoma via accumulation of 5'-deoxy-5'-methylthioadenosine (MTA). (Q34756307)

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English	Down-regulation of methylthioadenosine phosphorylase (MTAP) induces progression of hepatocellular carcinoma via accumulation of 5'-deoxy-5'-methylthioadenosine (MTA).	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 August 2017

Down-regulation of methylthioadenosine phosphorylase (MTAP) induces progression of hepatocellular carcinoma via accumulation of 5'-deoxy-5'-methylthioadenosine (MTA). (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

hepatocellular carcinoma

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inferred from title

Anja Bosserhoff

8

object named as

Anja K Bosserhoff

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Europe PubMed Central

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4 August 2017

object named as

Thomas S Weiss

5

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ORCID Public Data File 2021

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Georgi Kirovski

1

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Europe PubMed Central

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4 August 2017

Axel P Stevens

2

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Europe PubMed Central

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4 August 2017

Barbara Czech

3

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Europe PubMed Central

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4 August 2017

Katja Dettmer

4

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Europe PubMed Central

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4 August 2017

Peter Wild

6

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Europe PubMed Central

PubMed publication ID

4 August 2017

Arndt Hartmann

7

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4 August 2017

Peter J Oefner

9

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4 August 2017

Claus Hellerbrand

10

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4 August 2017

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publication date

28 January 2011

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Europe PubMed Central

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4 August 2017

The American Journal of Pathology

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4 August 2017

178

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Europe PubMed Central

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4 August 2017

3

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Europe PubMed Central

PubMed publication ID

4 August 2017

1145-1152

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Europe PubMed Central

PubMed publication ID

4 August 2017

Quantification of intermediates of the methionine and polyamine metabolism by liquid chromatography-tandem mass spectrometry in cultured tumor cells and liver biopsies

1 reference

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7 July 2018

GLUT1 as a therapeutic target in hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069916

7 July 2018

Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis and therapeutics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069916

7 July 2018

Epidemiology, screening, diagnosis and treatment of hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069916

7 July 2018

GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069916

7 July 2018

Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma

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7 July 2018

Quantitative analysis of 5'-deoxy-5'-methylthioadenosine in melanoma cells by liquid chromatography-stable isotope ratio tandem mass spectrometry

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069916

7 July 2018

Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis

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7 July 2018

The differential NF-kB modulation by S-adenosyl-L-methionine, N-acetylcysteine and quercetin on the promotion stage of chemical hepatocarcinogenesis

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7 July 2018

The novel gene MIA2 acts as a tumour suppressor in hepatocellular carcinoma

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7 July 2018

A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers

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7 July 2018

Genomics and signaling pathways in hepatocellular carcinoma.

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7 July 2018

Intracellular survival pathways in the liver

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7 July 2018

Comparative and integrative functional genomics of HCC.

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7 July 2018

Fibroblasts in cancer

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7 July 2018

Nuclear factor-kappaB and liver carcinogenesis

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7 July 2018

Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069916

7 July 2018

Genetic profiling of human hepatocellular carcinoma

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7 July 2018

Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma

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7 July 2018

Environmental factors and risk for hepatocellular carcinoma

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7 July 2018

The stroma reaction myofibroblast: a key player in the control of tumor cell behavior

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7 July 2018

Methylthioadenosine.

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7 July 2018

5'-methylthioadenosine modulates the inflammatory response to endotoxin in mice and in rat hepatocytes.

1 reference

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7 July 2018

A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069916

7 July 2018

Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell line

1 reference

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7 July 2018

Chemoprevention of hepatocarcinogenesis: S-adenosyl-L-methionine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069916

7 July 2018

Frequent allelic loss on chromosome 9 in hepatocellular carcinoma.

1 reference

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7 July 2018

Construction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene from the tumor suppressor region on 9p21

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7 July 2018

Methionine synthesis from 5'-methylthioadenosine in rat liver.

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7 July 2018

Constitutive activation of NF-kappaB in human hepatocellular carcinoma: evidence of a cytoprotective role.

1 reference

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26 October 2018

Interleukin 8 in human hepatocellular carcinoma correlates with cancer cell invasion of vessels but not with tumor angiogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069916

26 October 2018

Differential effects of deoxycholic acid and taurodeoxycholic acid on NF-kappa B signal transduction and IL-8 gene expression in colonic epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069916

26 October 2018

Collagen sandwich culture affects intracellular polyamine levels of human hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069916

26 October 2018

Methylthioadenosine phosphorylase gene deletions are common in osteosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069916

26 October 2018

S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069916

26 October 2018

The methylthioadenosine phosphorylase gene is frequently co-deleted with the p16INK4a gene in acute type adult T-cell leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069916

26 October 2018

Inhibition of the tyrosine kinase activity of the fibroblast growth factor receptor by the methyltransferase inhibitor 5'-methylthioadenosine.

1 reference

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26 October 2018

PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis

1 reference

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26 October 2018

Inhibition of cytokine production and endothelial expression of adhesion antigens by 5'-methylthioadenosine

1 reference

https://pubmed.ncbi.nlm.nih.gov/21356366

12 December 2020

based on heuristic

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Mutational study of p16CDKN2/MTS1/INK4A and p57KIP2 genes in hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21356366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation between growth inhibition and presence of 5'-methylthioadenosine in cells treated with interferon

1 reference

https://pubmed.ncbi.nlm.nih.gov/21356366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reciprocal relationship between methylation status and loss of heterozygosity at the p14(ARF) locus in Australian and South African hepatocellular carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/21356366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of lymphocyte function by a naturally occurring nucleoside: 5'-methylthioadenosine (MTA)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21356366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical significance of vascular endothelial growth factor and basic fibroblast growth factor gene expression in liver tumor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21356366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of EphA2, MMP-9, and MVD-CD34 in hepatocellular carcinoma: Implications for tumor progression and prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21356366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane-type matrix metalloproteinase-1(MT1-MMP) gene is overexpressed in highly invasive hepatocellular carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/21356366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current management of hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21356366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of 5'-methylthioadenosine on induction of murine erythroleukemia cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21356366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MTAP gene deletion in endometrial cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21356366

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of growth but not differentiation of normal and leukemic myeloid cells by methylthioadenosine

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1016/J.AJPATH.2010.11.059

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Europe PubMed Central

PubMed publication ID

4 August 2017

PMC publication ID

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Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

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Europe PubMed Central

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4 August 2017

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