The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation (Q34729763)

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English	The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 August 2017

The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation (English)

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Europe PubMed Central

PubMed publication ID

4 August 2017

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apoptotic process

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author name string

Claudio Scafoglio

1

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Europe PubMed Central

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4 August 2017

Marcus Smolka

2

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Europe PubMed Central

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4 August 2017

Huilin Zhou

3

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Europe PubMed Central

PubMed publication ID

4 August 2017

Valentina Perissi

4

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Europe PubMed Central

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4 August 2017

Michael G Rosenfeld

5

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4 August 2017

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publication date

17 May 2013

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Europe PubMed Central

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4 August 2017

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Europe PubMed Central

PubMed publication ID

4 August 2017

8

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Europe PubMed Central

PubMed publication ID

4 August 2017

5

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Europe PubMed Central

PubMed publication ID

4 August 2017

e59986

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Europe PubMed Central

PubMed publication ID

4 August 2017

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Creative Commons Attribution 4.0 International

17 May 2013

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April 2022 Public Data File from Crossref

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describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3656868/fullTextXML

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p53 dynamics control cell fate

1 reference

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Two-phase dynamics of p53 in the DNA damage response.

1 reference

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The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier

1 reference

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7 July 2018

Coping with DNA double strand breaks

1 reference

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Tumor Suppressor CHK2: Regulator of DNA Damage Response and Mediator of Chromosomal Stability

1 reference

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7 July 2018

Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.

1 reference

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7 July 2018

Deconstructing repression: evolving models of co-repressor action

1 reference

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7 July 2018

WIP1 phosphatase at the crossroads of cancer and aging

1 reference

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Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons

1 reference

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7 July 2018

Checkpoint mechanisms at the intersection between DNA damage and repair

1 reference

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7 July 2018

Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response

1 reference

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7 July 2018

Design principles of biochemical oscillators

1 reference

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7 July 2018

Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.

1 reference

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7 July 2018

TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints

1 reference

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CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?

1 reference

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SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron

1 reference

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Smad7 sensitizes tumor necrosis factor induced apoptosis through the inhibition of antiapoptotic gene expression by suppressing activation of the nuclear factor-kappaB pathway

1 reference

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7 July 2018

ATM activation and DNA damage response

1 reference

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Activated checkpoint kinase 2 provides a survival signal for tumor cells

1 reference

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7 July 2018

DNA damage-induced cell death by apoptosis.

1 reference

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7 July 2018

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1 reference

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7 July 2018

Life in the balance: how BH3-only proteins induce apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656868

7 July 2018

DNA damage regulates Chk2 association with chromatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656868

7 July 2018

Cycloheximide-mediated sensitization to TNF-alpha-induced apoptosis in human colorectal cancer cell line COLO 205; role of FLIP and metabolic inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656868

7 July 2018

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

1 reference

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7 July 2018

Coactivators and corepressors of NF-kappaB in IkappaB alpha gene promoter

1 reference

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7 July 2018

AP-1 subunits: quarrel and harmony among siblings

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7 July 2018

SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival

1 reference

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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656868

7 July 2018

Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656868

7 July 2018

A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors

1 reference

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Dynamics of the p53-Mdm2 feedback loop in individual cells

1 reference

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Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656868

7 July 2018

AP-1: a double-edged sword in tumorigenesis

1 reference

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Chk1 and Chk2 kinases in checkpoint control and cancer

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Chk2 activates E2F-1 in response to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656868

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Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1

1 reference

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Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656868

7 July 2018

N-CoR controls differentiation of neural stem cells into astrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656868

7 July 2018

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656868

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Chk2 activation and phosphorylation-dependent oligomerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656868

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656868

7 July 2018

The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656868

7 July 2018

Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3656868

7 July 2018

NF-kappaB signals induce the expression of c-FLIP.

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Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

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Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3

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The SMRT corepressor is regulated by a MEK-1 kinase pathway: inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export

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7 July 2018

The histone deacetylase-3 complex contains nuclear receptor corepressors

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A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness

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The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L).

1 reference

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7 July 2018

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

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7 July 2018

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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7 July 2018

Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

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7 July 2018

Control of cell cycle progression by c-Jun is p53 dependent

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

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7 July 2018

DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1.

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ch-IAP1, a Member of the Inhibitor-of-Apoptosis Protein Family, Is a Mediator of the Antiapoptotic Activity of the v-Rel Oncoprotein

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7 July 2018

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7 July 2018

Cooperation between STAT3 and c-jun suppresses Fas transcription.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0059986

21 January 2018

Long-term activation of SAPK/JNK, p38 kinase and fas-L expression by cisplatin is attenuated in human carcinoma cells that acquired drug resistance.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0059986

21 January 2018

Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks

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21 January 2018

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21 January 2018

The proto-oncogene c-myc and apoptosis

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12 December 2020

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10.1371/JOURNAL.PONE.0059986

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Europe PubMed Central

PubMed publication ID

4 August 2017

2013PLoSO...859986S

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PMC publication ID

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Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

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Europe PubMed Central

PubMed publication ID

4 August 2017

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