Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress. (Q34662248)

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English	Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress.	scientific article

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6 February 2020

Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress (English)

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6 February 2020

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Paloma B. Liton

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6 February 2020

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Yizhi Lin

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6 February 2020

David L Epstein

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23 June 2010

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6 February 2020

Investigative Ophthalmology Visual Science

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6 February 2020

51

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6 February 2020

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6 February 2020

6483-6495

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6 February 2020

Risks of copper and iron toxicity during aging in humans

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7 July 2018

Lysosomal destabilization and cathepsin B contributes for cytochrome c release and caspase activation in embelin-induced apoptosis

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7 July 2018

Maintaining Mammalian iron and oxygen homeostasis: sensors, regulation, and cross-talk

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7 July 2018

Iron homoeostasis in rheumatic disease

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Age-dependent and gender-specific changes in mouse tissue iron by strain

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Lysosomes as "suicide bags" in cell death: myth or reality?

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Iron toxicity in diseases of aging: Alzheimer's disease, Parkinson's disease and atherosclerosis

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Iron homeostasis and eye disease

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Iron, ferritin and proteins of the methionine-centered redox cycle in young and old rat hearts

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7 July 2018

Mitochondrial iron accumulation with age and functional consequences

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Apoptosis in the trabecular meshwork of glaucomatous patients

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7 July 2018

Iron accumulation with age, oxidative stress and functional decline

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A role for lysosomes in the turnover of human iron regulatory protein 2.

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7 July 2018

Cultured porcine trabecular meshwork cells display altered lysosomal function when subjected to chronic oxidative stress.

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7 July 2018

Intracellular iron transport and storage: from molecular mechanisms to health implications

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Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD

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7 July 2018

Changes in iron-regulatory proteins in the aged rodent neural retina

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7 July 2018

Lysosomes in iron metabolism, ageing and apoptosis

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7 July 2018

Lysosomes and oxidative stress in aging and apoptosis

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7 July 2018

Iron and paraquat as synergistic environmental risk factors in sporadic Parkinson's disease accelerate age-related neurodegeneration.

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7 July 2018

Oxidative stress in glaucoma: a burden of evidence

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7 July 2018

Cathepsin D-Bax death pathway in oxidative stressed neuroblastoma cells

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7 July 2018

The lysosomal-mitochondrial axis theory of postmitotic aging and cell death

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7 July 2018

Release of iron from ferritin requires lysosomal activity

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7 July 2018

Cellular regulation and molecular interactions of the ferritins.

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7 July 2018

Metallothionein protects against oxidative stress-induced lysosomal destabilization

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Cellular senescence in the glaucomatous outflow pathway

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Role of compartmentalized redox-active iron in hydrogen peroxide-induced DNA damage and apoptosis.

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7 July 2018

Iron accumulation during cellular senescence

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Alterations of intracellular pH homeostasis in apoptosis: origins and roles

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7 July 2018

Labile iron pool: the main determinant of cellular response to oxidative stress

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Iron Accumulation During Cellular Senescence in Human FibroblastsIn Vitro

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Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor

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Oxidative deoxyribonucleic acid damage in the eyes of glaucoma patients

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Modulation of cellular iron metabolism by hydrogen peroxide. Effects of H2O2 on the expression and function of iron-responsive element-containing mRNAs in B6 fibroblasts

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7 July 2018

Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route

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7 July 2018

Coordinate transcriptional and translational regulation of ferritin in response to oxidative stress

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7 July 2018

Preliminary characterization of a transformed cell strain derived from human trabecular meshwork

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7 July 2018

Trabecular meshwork cellularity. Differences between fellow eyes

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7 July 2018

Age-related iron deposition in the basal ganglia: quantitative analysis in healthy subjects

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26 October 2018

Sensitivity of ocular anterior chamber tissues to oxidative damage and its relevance to the pathogenesis of glaucoma.

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26 October 2018

Cellular and subcellular localizations of nonheme ferric and ferrous iron in the rat brain: a light and electron microscopic study by the perfusion-Perls and -Turnbull methods

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26 October 2018

Oxidative stress and glaucoma: injury in the anterior segment of the eye.

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26 October 2018

Oxidative stress in primary open-angle glaucoma

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26 October 2018

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26 October 2018

Cathepsin-cleaved Bid promotes apoptosis in human neutrophils via oxidative stress-induced lysosomal membrane permeabilization.

1 reference

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26 October 2018

Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue.

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26 October 2018

Intralysosomal iron chelation protects against oxidative stress-induced cellular damage.

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26 October 2018

Cathepsin D and H2O2 stimulate degradation of thioredoxin-1: implication for endothelial cell apoptosis

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26 October 2018

Oxidative DNA damage in the human trabecular meshwork: clinical correlation in patients with primary open-angle glaucoma.

1 reference

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26 October 2018

Lipid peroxidation in the pathogenesis of primary open-angle glaucoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055766

26 October 2018

Iron load and redox stress in skeletal muscle of aged rats

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3055766

9 December 2018

Age-related changes in trabecular meshwork cellularity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20574010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related changes in the trabecular meshwork of the normal human eye

1 reference

https://pubmed.ncbi.nlm.nih.gov/20574010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that desferrioxamine cannot enter cells by passive diffusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/20574010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygen in the anterior chamber of the human eye

1 reference

https://pubmed.ncbi.nlm.nih.gov/20574010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the activity of lysosomal cysteine proteinases by pH-induced inactivation and/or endogenous protein inhibitors, cystatins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20574010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A fluorescence assay for assessing chelation of intracellular iron in a membrane model system and in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20574010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron regulatory proteins, iron responsive elements and iron homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20574010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20574010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk factors for incident open-angle glaucoma: the Barbados Eye Studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/20574010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trabecular meshwork cellularity in primary open-angle glaucoma and nonglaucomatous normals

1 reference

https://pubmed.ncbi.nlm.nih.gov/20574010

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1167/IOVS.10-5410

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20574010%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

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Europe PubMed Central

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6 February 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20574010%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

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