Cardiac titin: an adjustable multi-functional spring (Q34664421)

3 August 2017

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title

Cardiac titin: an adjustable multi-functional spring (English)

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3 August 2017

Siegfried Labeit

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3 August 2017

Henk Granzier

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3 August 2017

language of work or name

English

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publication date

1 June 2002

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3 August 2017

published in

Journal of Physiology

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3 August 2017

volume

541

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3 August 2017

issue

Pt 2

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3 August 2017

page(s)

335-342

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The cellular basis of the length-tension relation in cardiac muscle

3 August 2017

cites work

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2001.014381

The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system

21 January 2018

1 reference

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Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain

21 January 2018

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Specific interaction of the potassium channel beta-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system

21 January 2018

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Passive tension and stiffness of vertebrate skeletal and insect flight muscles: the contribution of weak cross-bridges and elastic filaments

21 January 2018

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Identification of new repeating motifs in titin

21 January 2018

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Muscle assembly: a titanic achievement?

21 January 2018

1 reference

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The positional stability of thick filaments in activated skeletal muscle depends on sarcomere length: evidence for the role of titin filaments

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2001.014381

Titins: giant proteins in charge of muscle ultrastructure and elasticity

21 January 2018

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The giant protein titin. Emerging roles in physiology and pathophysiology

21 January 2018

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A spring tale: new facts on titin elasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2001.014381

I-band titin in cardiac muscle is a three-element molecular spring and is critical for maintaining thin filament structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2001.014381

Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2001.014381

Structural basis for activation of the titin kinase domain during myofibrillogenesis

21 January 2018

1 reference

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Muscle-specific calpain, p94, responsible for limb girdle muscular dystrophy type 2A, associates with connectin through IS2, a p94-specific sequence

21 January 2018

1 reference

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Titin: a molecular control freak

21 January 2018

1 reference

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Molecular dissection of N2B cardiac titin's extensibility

21 January 2018

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Titin extensibility in situ: entropic elasticity of permanently folded and permanently unfolded molecular segments

21 January 2018

1 reference

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Extensibility of isoforms of cardiac titin: variation in contour length of molecular subsegments provides a basis for cellular passive stiffness diversity

21 January 2018

1 reference

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Titin: an endosarcomeric protein that modulates myocardial stiffness in DCM.

21 January 2018

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Titin-actin interaction in mouse myocardium: passive tension modulation and its regulation by calcium/S100A1

21 January 2018

1 reference

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Protein kinase A phosphorylates titin's cardiac-specific N2B domain and reduces passive tension in rat cardiac myocytes

21 January 2018

1 reference

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Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly

21 January 2018

1 reference

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Mechanical properties of titin isoforms

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290327

Stretching molecular springs: elasticity of titin filaments in vertebrate striated muscle

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290327

Connectin/titin, giant elastic protein of muscle.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290327

Titin/connectin and nebulin: giant protein rulers of muscle structure and function

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290327

Structural and functional studies of titin’s fn3 modules reveal conserved surface patterns and binding to myosin S1 - a possible role in the frank-starling mechanism of the heart

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290327

Interaction between PEVK-titin and actin filaments: origin of a viscous force component in cardiac myofibrils

9 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2290327

Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity

9 December 2018

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12 December 2020

Alterations in the determinants of diastolic suction during pacing tachycardia

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12 December 2020

Changes in titin and collagen underlie diastolic stiffness diversity of cardiac muscle

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12 December 2020

Titin-based modulation of calcium sensitivity of active tension in mouse skinned cardiac myocytes

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12 December 2020

Cardiac titin isoforms are coexpressed in the half-sarcomere and extend independently

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12 December 2020

Length dependence of tension generation in rat skinned cardiac muscle: role of titin in the Frank-Starling mechanism of the heart

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12 December 2020

Beta-adrenergic receptor stimulation increases unloaded shortening velocity of skinned single ventricular myocytes from rats

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12 December 2020

Osmotic compression of single cardiac myocytes eliminates the reduction in Ca2+ sensitivity of tension at short sarcomere length

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12 December 2020

The mechanically active domain of titin in cardiac muscle

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12 December 2020

Titin develops restoring force in rat cardiac myocytes

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12 December 2020

Sarcomere length versus interfilament spacing as determinants of cardiac myofilament Ca2+ sensitivity and Ca2+ binding

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12 December 2020

Actin removal from cardiac myocytes shows that near Z line titin attaches to actin while under tension

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12 December 2020

Differential expression of cardiac titin isoforms and modulation of cellular stiffness

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12 December 2020

Myofilament calcium sensitivity in skinned rat cardiac trabeculae: role of interfilament spacing

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12 December 2020

10.1113/JPHYSIOL.2001.014381

Identifiers

DOI

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3 August 2017

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