A PREVIOUSLY UNKNOWN UNIQUE CHALLENGE FOR INHIBITORS OF SYK ATP-BINDING SITE: ROLE OF SYK AS A CELL CYCLE CHECKPOINT REGULATOR (Q34653474)

3 August 2017

title

A PREVIOUSLY UNKNOWN UNIQUE CHALLENGE FOR INHIBITORS OF SYK ATP-BINDING SITE: ROLE OF SYK AS A CELL CYCLE CHECKPOINT REGULATOR (English)

1 reference

3 August 2017

Fatih M Uckun

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3 August 2017

Sanjive Qazi

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3 August 2017

Hong Ma

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3 August 2017

Zahide Ozer

series ordinal

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3 August 2017

Patricia Goodman

series ordinal

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3 August 2017

Jian Zhang

series ordinal

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3 August 2017

publication date

1 November 2014

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3 August 2017

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3 August 2017

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3 August 2017

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3 August 2017

page(s)

16-28

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Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival.

3 August 2017

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7 July 2018

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7 July 2018

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Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros

7 July 2018

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Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates.

7 July 2018

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Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance

7 July 2018

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Contributions made by CDC25 phosphatases to proliferation of intestinal epithelial stem and progenitor cells

7 July 2018

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Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor

7 July 2018

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Spleen tyrosine kinase as a molecular target for treatment of leukemias and lymphomas

7 July 2018

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Low molecular weight cyclin E overexpression shortens mitosis, leading to chromosome missegregation and centrosome amplification

7 July 2018

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Cyclin E deregulation impairs mitotic progression through premature activation of Cdc25C.

7 July 2018

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The SYK tyrosine kinase: a crucial player in diverse biological functions

7 July 2018

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Regulation of developmental lymphangiogenesis by Syk(+) leukocytes

7 July 2018

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STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress

7 July 2018

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Polo-like-kinase 1 (PLK1) as a molecular target to overcome SYK-mediated resistance of B-lineage acute lymphoblastic leukaemia cells to oxidative stress

7 July 2018

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The decision to enter mitosis: feedback and redundancy in the mitotic entry network

7 July 2018

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Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy

7 July 2018

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In vivo roles of CDC25 phosphatases: biological insight into the anti-cancer therapeutic targets

7 July 2018

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Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage

7 July 2018

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7 July 2018

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Cdc25 and Wee1: analogous opposites?

7 July 2018

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Nucleocytoplasmic trafficking of the Syk protein tyrosine kinase

7 July 2018

1 reference

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The Syk tyrosine kinase localizes to the centrosomes and negatively affects mitotic progression.

7 July 2018

1 reference

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Transcription repressor activity of spleen tyrosine kinase mediates breast tumor suppression

7 July 2018

1 reference

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Regulation of cell cycle checkpoints by polo-like kinases

7 July 2018

1 reference

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Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation

7 July 2018

1 reference

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Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.

7 July 2018

1 reference

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Regulating mammalian checkpoints through Cdc25 inactivation

7 July 2018

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Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

7 July 2018

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G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.

7 July 2018

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Absence of apparent phenotype in mice lacking Cdc25C protein phosphatase

7 July 2018

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7 July 2018

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Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25.

7 July 2018

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C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding

7 July 2018

1 reference

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Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259291

BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259291

Syk tyrosine kinase required for mouse viability and B-cell development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259291

Therapeutic potential of spleen tyrosine kinase inhibition for treating high-risk precursor B cell acute lymphoblastic leukemia.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259291

Human Plk4 phosphorylates Cdc25C.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259291

ATM requirement in gene expression responses to ionizing radiation in human lymphoblasts and fibroblasts.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259291

Dynamic mechanism for the autophosphorylation of CheA histidine kinase: molecular dynamics simulations

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259291

A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259291

Spleen tyrosine kinase (Syk) deficiency in childhood pro-B cell acute lymphoblastic leukemia

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259291

Syk Is Required for p38 Activation and G2/M Arrest in B Cells Exposed to Oxidative Stress

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4259291

The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase

9 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25506060

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.EBIOM.2014.10.019

0 references

PMC publication ID

4259291

1 reference

3 August 2017

1 reference