Species differences in pharmacokinetics and drug teratogenesis (Q34659193)

3 August 2017

title

Species differences in pharmacokinetics and drug teratogenesis (English)

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3 August 2017

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Nau H

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3 August 2017

publication date

1 December 1986

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Environmental Health Perspectives

3 August 2017

published in

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3 August 2017

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3 August 2017

page(s)

113-129

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Toxicology, carcinogenicity, and teratogenicity of some orally administered retinoids.

3 August 2017

cites work

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The current status of attempts to predict species differences in drug metabolism

7 July 2018

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Biotransformation of xenobiotics in the fetus

7 July 2018

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Thalidomide teratogenesis: evidence for a toxic arene oxide metabolite

7 July 2018

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Comparative distribution and metabolism of triamcinolone acetonide and cortisol in the rat embryomaternal unit

7 July 2018

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Anticonvulsants during pregnancy and lactation. Transplacental, maternal and neonatal pharmacokinetics

7 July 2018

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Pharmacokinetics and toxicity testing

7 July 2018

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Dose-Dependent Pharmacokinetics: Emphasis on Phase I Metabolism

7 July 2018

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Fetal toxicity of benzodiazepines in rats

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Metabolism of phenytoin in teratogenesis-susceptible and -resistant strains of mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Comparative Drug Metabolism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Abnormalities of intrauterine development in non-human primates

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Constant rate exposure of pregnant hamsters to arsenate during early gestation

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Differential pharmacokinetics for oral and intraperitoneal administration of ethanol to the pregnant guinea pig.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Etretinate kinetics during chronic dosing in severe psoriasis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Embryonal malformation following etretinate therapy of Darier's disease in the mother

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Teratogenic valproic acid concentrations: infusion by implanted minipumps vs conventional injection regimen in the mouse

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Significance of species and strain differences in pre- and perinatal toxicology

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Oxidation and glucuronidation of valproic acid in male rats--influence of phenobarbital, 3-methylcholanthrene, beta-naphthoflavone and clofibrate

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Species sensitivities and prediction of teratogenic potential

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Clinical pharmacokinetics in pregnancy and perinatology. I. Placental transfer and fetal side effects of local anaesthetic agents.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Retinoic acid embryopathy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Weak acids may act as teratogens by accumulating in the basic milieu of the early mammalian embryo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Fetal growth, major malformations, and minor anomalies in infants born to women receiving valproic acid

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Pharmacologic evaluation of various metabolites and analogs of valproic acid: teratogenic potencies in mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Valproic acid teratogenicity in mice after various administration and phenobarbital-pretreatment regimens: the parent drug and not one of the metabolites assayed is implicated as teratogen

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Cyclophosphamide teratogenesis: a review

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Comparative distribution and embryotoxicity of hydroxyurea in pregnant rats and rhesus monkeys

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Comparative placental morphology and function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Placental transfer of chlorthalidone and its elimination in maternal milk.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

The murine Ah locus: in utero toxicity and teratogenesis associated with genetic differences in benzo[a]pyrene metabolism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Comparative distribution and embryotoxicity of acetylsalicylic acid in pregnant rats and rhesus monkeys

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Teratogenic effects of retinoic acid in pigtail monkeys (Macaca nemestrina) I. General features

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Species Differences in Microsomal Monooxygenase Activity and Their Relationship to Biological Half-Lives

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Placental Transfer and Fetal Urinary Excretion of Gentamicin during Constant Rate Maternal Infusion

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Transfer characteristics of triamterene and its analogs. Central nervous system, placenta, and kidney

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Comparative distribution and embryotoxicity of methotrexate in pregnant rats and rhesus monkeys

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Teratological and radiocephalometric analysis of craniofacial malformations induced with retinoic acid in rhesus monkeys (Macaca mulatta).

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Genetic differences in phenytoin pharmacokinetics. In vivo clearance and in vitro metabolism among inbred strains of mice.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Modification of the mutagenicity and teratogenicity of cyclophosphamide in rats with inducers of the cytochromes P-450.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Embryotoxicity induced by alkylating agents. Teratogenicity of acetoxymethyl-methylnitrosamine: dose-response relationship, application route dependency and phase specificity

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Valproic acid: metabolite concentrations in plasma and brain, anticonvulsant activity, and effects on GABA metabolism during subacute treatment in mice.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Mutagenic, teratogenic and pharmacokinetic properties of cyclophosphamide and some of its deuterated derivatives

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Accumulation in murine amniotic fluid of halothane and its metabolites

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Serum protein binding of diazepam, desmethyldiazepam, furosemide, indomethacin, warfarin, and phenobarbital in human fetus, mother, and newborn infant.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Differences in in vitro binding of diazepam and N-desmethyldiazepam to maternal and fetal plasma proteins at birth: relation to free fatty acid concentration and other parameters.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Valproic Acid and Metabolites: Pharmacological and Toxicological Studies

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Generation of reactive dysmorphogenic intermediates by rat embryos in culture: effects of cytochrome P-450 inducers

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Teratogenesis and reproductive safety evaluation of the retinoid etretin (Ro 10-1670).

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1474298

Transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to the mouse embryo and fetus

26 October 2018

1 reference

12 December 2020

A new model for embryotoxicity testing: teratogenicity and pharmacokinetics of valproic acid following constant-rate administration in the mouse using human therapeutic drug and metabolite concentrations

1 reference

12 December 2020

Disposition of 13-cis-retinoic acid and N-(2-hydroxyethyl)retinamide in mice after oral doses

1 reference

12 December 2020

Congenital malformations induced by infusion of sodium cyanide in the golden hamster

1 reference

12 December 2020

The value of animal teratogenicity testing for predicting human risk

1 reference

12 December 2020

Teratogenesis of calcium valproate in rats

1 reference

12 December 2020

Correlating pharmacokinetics and teratogenic endpoints

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12 December 2020

A comparative study on the pharmacokinetics of valpramide after intravenous administration in dogs

1 reference

12 December 2020

Possible teratogenic effect of valproate during pregnancy

1 reference

12 December 2020

Relationship between trimethadione metabolism and hepatic drug-oxidizing enzyme activities in different animal species

1 reference

12 December 2020

[Placental passage of nalidixic acid (Negram) and pharmacokinetic studies in the newborn infant]

1 reference

12 December 2020

Determination of the proximate teratogen of the mouse fetal alcohol syndrome. 1. Teratogenicity of ethanol and acetaldehyde

1 reference

12 December 2020

Determination of the proximate teratogen of the mouse fetal alcohol syndrome. 2. Pharmacokinetics of the placental transfer of ethanol and acetaldehyde

1 reference

12 December 2020

Pharmacokinetics of valproic acid obtained after administration of three oral formulations to humans

1 reference

12 December 2020

Studies on the pharmacological bases of fetal toxicity of drugs (IV). Effect of endotoxin and starvation on serum protein binding of salicylic acid in pregnant rats

1 reference

12 December 2020

Amelioration of embryotoxicity by structural modification of the terminal group of cancer chemopreventive retinoids

1 reference

12 December 2020

Anticonvulsant activity and embryotoxicity of valproic acid

1 reference

12 December 2020

Importance of the route of administration for genetic differences in benzo[a]pyrene-induced in utero toxicity and teratogenicity

1 reference

12 December 2020

Enhancement effects of barbital on the teratogenicity of aminopyrine

1 reference

12 December 2020

Valproic acid in the perinatal period: decreased maternal serum protein binding results in fetal accumulation and neonatal displacement of the drug and some metabolites

1 reference

12 December 2020

Comparative pharmacokinetics of 14C-piperacillin following intravenous and intraperitoneal administration in pregnant and non-pregnant rats

1 reference

12 December 2020

[Teratogenic effects of etretinate in humans]

1 reference

12 December 2020

Decreased placental monooxygenase activities associated with birth defects

1 reference

12 December 2020

Transuterine passage of drugs in the rat

1 reference

12 December 2020

Comparative teratogenic activities of two retinoids: Effects on palate and limb development

1 reference

12 December 2020

Drug metabolism in man and its relationship to that in three rodent species: monooxygenase, epoxide hydrolase, and glutathione S-transferase activities in subcellular fractions of lung and liver

1 reference

12 December 2020

Teratogenic effects of dosage levels and time of administration of carbamazepine, sodium valproate, and diphenylhydantoin on craniofacial development in the CD-1 mouse fetus

1 reference

12 December 2020

Prediction of the disposition of beta-lactam antibiotics in humans from pharmacokinetic parameters in animals

1 reference

12 December 2020

Teratogenic dose-response relationships of etretinate in the golden hamster

1 reference

12 December 2020

Reduction of caffeine teratogenicity in mice by inducing maternal drug metabolism with beta-naphthoflavone

1 reference

12 December 2020

Interspecies comparison of in vivo caffeine pharmacokinetics in man, monkey, rabbit, rat, and mouse

1 reference

12 December 2020

Pharmacological evaluation of various metabolites and analogues of valproic acid. Anticonvulsant and toxic potencies in mice

1 reference

12 December 2020

Effects of acute or chronic polychlorinated biphenyl ingestion on maternal metabolic homeostasis and on the manifestations of embryotoxicity caused by cyclophosphamide in mice

1 reference

12 December 2020

Constant rate of infusion--improvement of tests for teratogenicity and embryotoxicity

1 reference

12 December 2020

Caffeine disposition after oral administration to pregnant rats

1 reference

12 December 2020

Serum protein binding of valproic acid in fetus-mother pairs throughout pregnancy: correlation with oxytocin administration and albumin and free fatty acid concentrations

1 reference

12 December 2020

Predicting the human teratogenic potential of the anticonvulsant, valproic acid, from a non-human primate model

1 reference

12 December 2020

Pharmacokinetic aspects of drug effects in vitro: effects of serum protein binding on concentration and teratogenicity of valproic acid and 2-en-valproic acid in whole embryos in culture

1 reference

12 December 2020

Comparison of the disposition of diethylstilbestrol and estradiol in the fetal rat. Correlation with teratogenic potency

1 reference

12 December 2020

Transfer of valproic acid and its main active unsaturated metabolite to the gestational tissue: correlation with neural tube defect formation in the mouse

1 reference

12 December 2020

BIOCHEMICAL EFFECTS OF DRUGS ON THE MAMMALIAN CONCEPTUS

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12 December 2020

Some pharmacological consequences of species variation in rates of metabolism

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12 December 2020

Transplacental passage of methicillin and dicloxacillin into the fetus and amniotic fluid

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12 December 2020

Transplacental passage of erythromycin and clindamycin

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12 December 2020

Distribution of salicylate between neonatal and maternal serum at diffusion equilibrium

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12 December 2020

The enhancement effect of phenobarbital on toxicity of furylfuramide in mouse embryo

1 reference

12 December 2020

Alteration of delta 9-tetrahydrocannabinol-induced teratogenicity by stimulation and inhibition of its metabolism

1 reference

12 December 2020

Phenytoin teratogenesis: correlation between embryopathic effect and covalent binding of putative arene oxide metabolite in gestational tissue

1 reference

12 December 2020

Controlled release of tetracycline—III: A physiological pharmacokinetic model of the pregnant rat

1 reference

12 December 2020

Dose-dependent kinetics of all-trans-retinoic acid in rats. Plasma levels and excretion into bile, urine, and faeces

1 reference

12 December 2020

Disposition of all-trans-retinoic acid in mice following oral doses

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12 December 2020

Identifiers

DOI

10.1289/EHP.8670113

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3 August 2017

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3 August 2017

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