CGRP receptor antagonists: an expanding drug class for acute migraine? (Q34637610)

3 August 2017

title

CGRP receptor antagonists: an expanding drug class for acute migraine? (English)

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3 August 2017

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Paolo Martelletti

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3 August 2017

Andrea Negro

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3 August 2017

Luana Lionetto

series ordinal

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3 August 2017

Maurizio Simmaco

series ordinal

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3 August 2017

language of work or name

English

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publication date

19 April 2012

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Expert Opinion on Investigational Drugs

3 August 2017

published in

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3 August 2017

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3 August 2017

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3 August 2017

page(s)

807-818

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Population variation in migraine prevalence: a meta-analysis.

3 August 2017

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Elevated saliva calcitonin gene-related peptide levels during acute migraine predict therapeutic response to rizatriptan

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The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats.

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Calcitonin Gene-Related Peptide Does Not Cause Migraine Attacks in Patients With Familial Hemiplegic Migraine

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No increase of calcitonin gene-related peptide in jugular blood during migraine

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Dilation by CGRP of middle meningeal artery and reversal by sumatriptan in normal volunteers

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21 January 2018

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Chest symptoms after sumatriptan: a two-year clinical practice review in 735 consecutive migraine patients

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin

21 January 2018

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Discovery of MK-3207: A Highly Potent, Orally Bioavailable CGRP Receptor Antagonist

21 January 2018

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Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: discovery of MK-2918.

21 January 2018

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Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin

21 January 2018

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Glycosylation of human CRLR at Asn123 is required for ligand binding and signaling

21 January 2018

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Identification of the human receptor activity-modifying protein 1 domains responsible for agonist binding specificity

21 January 2018

1 reference

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The extreme N-terminus of the calcitonin-like receptor contributes to the selective interaction with adrenomedullin or calcitonin gene-related peptide

21 January 2018

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Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists

21 January 2018

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Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-relate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Effects of the CGRP receptor antagonist BIBN4096BS on capsaicin-induced carotid haemodynamic changes in anaesthetised pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Effects of BIBN4096BS on cardiac output distribution and on CGRP-induced carotid haemodynamic responses in the pig.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Efficacy of the non-peptide CGRP receptor antagonist BIBN4096BS in blocking CGRP-induced dilations in human and bovine cerebral arteries: potential implications in acute migraine treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Effects of the calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS on alpha-CGRP-induced regional haemodynamic changes in anaesthetised rats

21 January 2018

1 reference

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Inhibitory effect of BIBN4096BS on cephalic vasodilatation induced by CGRP or transcranial electrical stimulation in the rat

21 January 2018

1 reference

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The CGRP-antagonist, BIBN4096BS does not affect cerebral or systemic haemodynamics in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

The nonpeptide calcitonin gene-related peptide receptor antagonist BIBN4096BS lowers the activity of neurons with meningeal input in the rat spinal trigeminal nucleus.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Future drugs for migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Randomized controlled trial of an oral CGRP receptor antagonist, MK-0974, in acute treatment of migraine

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Randomized controlled study of telcagepant plus ibuprofen or acetaminophen in migraine

21 January 2018

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Randomized, controlled trial of telcagepant over four migraine attacks

21 January 2018

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Long-Term Tolerability of Telcagepant for Acute Treatment of Migraine in a Randomized Trial

21 January 2018

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Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Randomized, controlled trial of telcagepant for the acute treatment of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

The potent calcitonin gene‐related peptide receptor antagonist, telcagepant, does not affect nitroglycerin‐induced vasodilation in healthy men

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Randomized controlled trial of the CGRP receptor antagonist MK-3207 in the acute treatment of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: Results from a phase II study

21 January 2018

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Oral triptans (serotonin 5-HT(1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Excellent Tolerability But Relatively Low Initial Clinical Efficacy of Telcagepant in Migraine

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Optimal balance of efficacy and tolerability of oral triptans and telcagepant: a review and a clinical comment

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2012.681044

Possible site of action of CGRP antagonists in migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

The N-Terminal Extracellular Domain 23−60 of the Calcitonin Receptor-Like Receptor in Chimeras with the Parathyroid Hormone Receptor Mediates Association with Receptor Activity-Modifying Protein 1†

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.681044

10.1517/13543784.2012.681044

21 January 2018

Identifiers

DOI

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3 August 2017

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