The hypocretins: setting the arousal threshold (Q34623823)

3 August 2017

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title

The hypocretins: setting the arousal threshold (English)

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hypocretin receptor binding

3 August 2017

main subject

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Gene Ontology release 2020-05-02

J Gregor Sutcliffe

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3 August 2017

Luis de Lecea

series ordinal

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3 August 2017

language of work or name

English

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publication date

1 May 2002

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Nature Reviews Neuroscience

3 August 2017

published in

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3 August 2017

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3 August 2017

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3 August 2017

page(s)

339-349

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Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction

3 August 2017

cites work

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The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

21 January 2018

1 reference

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

21 January 2018

1 reference

Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B

21 January 2018

1 reference

A 1H-NMR study of the solution conformation of secretin. Resonance assignment and secondary structure

21 January 2018

1 reference

Distribution of orexin receptor mRNA in the rat brain

21 January 2018

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Differential expression of orexin receptors 1 and 2 in the rat brain

21 January 2018

1 reference

Somnolence, akinesia, and sensory activation of motivated behavior in the lateral hypothalamic syndrome

21 January 2018

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The lateral hypothalamic area revisited: neuroanatomy, body weight regulation, neuroendocrinology and metabolism

21 January 2018

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The lateral hypothalamic area revisited: ingestive behavior

21 January 2018

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A role for melanin-concentrating hormone in the central regulation of feeding behaviour

21 January 2018

1 reference

Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems

21 January 2018

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Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area

21 January 2018

1 reference

Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus

21 January 2018

1 reference

The suprachiasmatic nucleus projects to posterior hypothalamic arousal systems.

21 January 2018

1 reference

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

21 January 2018

1 reference

Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

21 January 2018

1 reference

Orexin receptors couple to Ca2+ channels different from store-operated Ca2+ channels

21 January 2018

1 reference

Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR

21 January 2018

1 reference

Orexin-a activates phospholipase C- and protein kinase C-mediated Ca2+ signaling in dopamine neurons of the ventral tegmental area

21 January 2018

1 reference

Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis

21 January 2018

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Expression and coupling characteristics of the CRH and orexin type 2 receptors in human fetal adrenals

21 January 2018

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Interaction of the hypocretins with neurotransmitters in the nucleus accumbens

21 January 2018

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Widespread distribution of orexin in rat brain and its regulation upon fasting

21 January 2018

1 reference

Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action

21 January 2018

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Effect of intracerebroventricular orexin-B on food intake in sheep

21 January 2018

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Down regulation of the prepro-orexin gene expression in genetically obese mice

21 January 2018

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Hypothalamic hypocretin/orexin and neuropeptide Y: divergent interaction with energy depletion and leptin

21 January 2018

1 reference

Leptin regulation of prepro-orexin and orexin receptor mRNA levels in the hypothalamus

21 January 2018

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Neuropeptide Y in central control of feeding and interactions with orexin and leptin

21 January 2018

1 reference

Insulin-induced hypoglycemia increases preprohypocretin (orexin) mRNA in the rat lateral hypothalamic area

21 January 2018

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Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia

21 January 2018

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Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels: responses inhibited by feeding and possibly mediated by the nucleus of the solitary tract

21 January 2018

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Lowering glucose concentrations increases cytosolic Ca2+ in orexin neurons of the rat lateral hypothalamus

21 January 2018

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Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats

21 January 2018

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The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin

21 January 2018

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Feeding response to central orexins

21 January 2018

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Distribution and quantification of immunoreactive orexin A in rat tissues.

21 January 2018

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Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus

21 January 2018

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Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities

21 January 2018

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Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation.

21 January 2018

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Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight

21 January 2018

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Reconceptualizing support systems for persons with challenging behaviors

21 January 2018

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Evidence that orexin-containing neurones provide direct input to gonadotropin-releasing hormone neurones in the ovine hypothalamus

21 January 2018

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Activation of ventrolateral preoptic neurons during sleep

21 January 2018

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Orexin synthesis and response in the gut.

21 January 2018

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Cardiovascular regulatory actions of the hypocretins in brain

21 January 2018

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Orexins/hypocretins regulate drinking behaviour

21 January 2018

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Stimulation of gastric acid secretion by centrally administered orexin-A in conscious rats.

21 January 2018

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The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats

21 January 2018

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Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action

21 January 2018

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Orexin A interactions in the hypothalamo-pituitary gonadal axis

21 January 2018

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Orexins stimulate corticosterone secretion of rat adrenocortical cells, through the activation of the adenylate cyclase-dependent signaling cascade

21 January 2018

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The central effects of orexin-A in the hypothalamic-pituitary-adrenal axis in vivo and in vitro in male rats

21 January 2018

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Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity

21 January 2018

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Hypocretin (orexin) in the rat pineal gland: a central transmitter with effects on noradrenaline-induced release of melatonin

21 January 2018

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Hypocretin-2 (orexin-B) modulation of superficial dorsal horn activity in rat

21 January 2018

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Orexin-A, an hypothalamic peptide with analgesic properties

21 January 2018

1 reference

The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene

21 January 2018

1 reference

Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines

21 January 2018

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Thalamocortical oscillations in the sleeping and aroused brain

21 January 2018

1 reference

Sleep and arousal: thalamocortical mechanisms

21 January 2018

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The sleep switch: hypothalamic control of sleep and wakefulness

21 January 2018

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Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

21 January 2018

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To eat or to sleep? Orexin in the regulation of feeding and wakefulness

21 January 2018

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Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups

21 January 2018

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Hypocretin (orexin) deficiency in human narcolepsy.

21 January 2018

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CSF hypocretin/orexin levels in narcolepsy and other neurological conditions.

21 January 2018

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A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

21 January 2018

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Reduced number of hypocretin neurons in human narcolepsy

21 January 2018

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Narcolepsy and the HLA region

21 January 2018

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Sleep-waking discharge patterns of neurons recorded in the rat perifornical lateral hypothalamic area

21 January 2018

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Hypocretin receptor protein and mRNA expression in the dorsolateral pons of rats

21 January 2018

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Sleep cycle oscillation: reciprocal discharge by two brainstem neuronal groups

21 January 2018

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Hypocretin/orexin depolarizes and decreases potassium conductance in locus coeruleus neurons

21 January 2018

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Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat.

21 January 2018

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Orexins (hypocretins) directly excite tuberomammillary neurons

21 January 2018

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Orexins activate histaminergic neurons via the orexin 2 receptor

21 January 2018

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Arousal effect of orexin A depends on activation of the histaminergic system

21 January 2018

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Hypocretin/orexin, sleep and narcolepsy

21 January 2018

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A cortical neuropeptide with neuronal depressant and sleep-modulating properties

21 January 2018

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Effects on sleep and wakefulness of the injection of hypocretin-1 (orexin-A) into the laterodorsal tegmental nucleus of the cat.

21 January 2018

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The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders.

21 January 2018

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Orexins/hypocretins excite basal forebrain cholinergic neurones

21 January 2018

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Peptides crossing the blood-brain barrier: some unusual observations

21 January 2018

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Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy

21 January 2018

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Increased body-mass index in patients with narcolepsy.

21 January 2018

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Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity

21 January 2018

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Hypocretin is an early member of the incretin gene family

21 January 2018

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Hypothalamic thermoregulatory pathways in the rat

31 March 2020

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Neurons containing hypocretin (orexin) project to multiple neuronal systems

31 March 2020

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Orexin (hypocretin) neurons contain dynorphin.

31 March 2020

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Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin.

31 March 2020

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Orexin depolarizes rat hypothalamic paraventricular nucleus neurons

31 March 2020

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Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats

31 March 2020

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Orexin-induced food intake involves neuropeptide Y pathway

31 March 2020

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Inhibition of food intake by central injection of anti-orexin antibody in fasted rats

31 March 2020

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Alteration of the expression of the hypocretin (orexin) gene by 2-deoxyglucose in the rat lateral hypothalamic area

31 March 2020

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Independent feeding and metabolic actions of orexins in mice

31 March 2020

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The effect of food deprivation and experimental diabetes on orexin and NPY mRNA levels

31 March 2020

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Functional organization of central pathways regulating the cardiovascular system

31 March 2020

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Sympathetic and cardiovascular actions of orexins in conscious rats

31 March 2020

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Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats

31 March 2020

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Energy expenditure by intracerebroventricular administration of orexin to anesthetized rats

31 March 2020

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Orexin-A regulates body temperature in coordination with arousal status.

31 March 2020

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Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons.

31 March 2020

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Orexins, a novel family of hypothalamic neuropeptides, modulate pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner

31 March 2020

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Acute orexin effects on insulin secretion in the rat: in vivo and in vitro studies

31 March 2020

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Possible involvement of orexin in the stress reaction in rats

31 March 2020

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Hypocretin/orexin suppresses corticotroph responsiveness in vitro

31 March 2020

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Hypocretin-2-saporin lesions of the lateral hypothalamus produce narcoleptic-like sleep behavior in the rat.

31 March 2020

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Fos expression in orexin neurons varies with behavioral state.

31 March 2020

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Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle

31 March 2020

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Loss of behavioral thermoregulation after lateral hypothalamic lesions in rats

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRN808

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Dimensions Publication ID

3 August 2017

1001025952

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