Targeting protein-protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease (Q34621208)

3 August 2017

title

Targeting protein-protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease (English)

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protein-protein interaction

3 August 2017

main subject

cardiovascular disease

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based on heuristic

inferred from title

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Louisa C Y Lee

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3 August 2017

Donald H Maurice

series ordinal

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3 August 2017

George S Baillie

series ordinal

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3 August 2017

publication date

1 March 2013

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Future Medicinal Chemistry

3 August 2017

published in

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3 August 2017

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3 August 2017

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3 August 2017

page(s)

451-464

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Earl Sutherland (1915-1974) [corrected] and the discovery of cyclic AMP.

3 August 2017

cites work

1 reference

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Cyclic nucleotide research -- still expanding after half a century

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Cyclic AMP: master regulator of innate immune cell function.

21 January 2018

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Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

21 January 2018

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Roles of cyclic adenosine monophosphate signaling in endothelial cell differentiation and arterial-venous specification during vascular development

21 January 2018

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A molecular switch for the consolidation of long-term memory: cAMP-inducible gene expression.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.216

Synchronizing Ca2+ and cAMP oscillations in pancreatic beta-cells: a role for glucose metabolism and GLP-1 receptors? Focus on "regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Compartmentalized cAMP/PKA signalling regulates cardiac excitation-contraction coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Cardiac excitation-contraction coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Epac enhances excitation-transcription coupling in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Cyclic nucleotide-gated channels in non-sensory organs

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Networking with AKAPs: context-dependent regulation of anchored enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Assessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

A-kinase anchoring proteins as potential drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Epac proteins: multi-purpose cAMP targets

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Tailoring cAMP-signalling responses through isoform multiplicity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Keynote review: phosphodiesterase-4 as a therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

The unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA).

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

The cardiac IKs potassium channel macromolecular complex includes the phosphodiesterase PDE4D3

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Phosphodiesterase inhibitors: factors that influence potency, selectivity, and action

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Phosphodiesterase-4 as a potential drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

High-density synthetic peptide microarrays: emerging tools for functional genomics and proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Dynamic regulation, desensitization, and cross-talk in discrete subcellular microdomains during beta2-adrenoceptor and prostanoid receptor cAMP signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

A major functional role for phosphodiesterase 4D5 in human airway smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Large potentials of small heat shock proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

The emerging role of HSP20 as a multifunctional protective agent

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

PKA phosphorylation of the small heat-shock protein Hsp20 enhances its cardioprotective effects

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser(16).

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

A novel small molecule target in human airway smooth muscle for potential treatment of obstructive lung diseases: a staged high-throughput biophysical screening

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Hold me tight: Role of the heat shock protein family of chaperones in cardiac disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Small heat-shock protein Hsp20 phosphorylation inhibits beta-agonist-induced cardiac apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Transduction of phosphorylated heat shock-related protein 20, HSP20, prevents vasospasm of human umbilical artery smooth muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

The small heat shock protein, HSPB6, in muscle function and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

The small heat shock-related protein, HSP20, is a cAMP-dependent protein kinase substrate that is involved in airway smooth muscle relaxation.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

The possibility of novel antiplatelet peptides: the physiological effects of low molecular weight HSPs on platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

The role of intracellular 3'5'-cyclic adenosine monophosphate (cAMP) in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Emerging themes of cAMP regulation of the pulmonary endothelial barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Functional characterization of the cAMP-binding proteins Epac in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Epac activation induces histone deacetylase nuclear export via a Ras-dependent signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Signaling of the direction-sensing FAK/RACK1/PDE4D5 complex to the small GTPase Rap1

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

AKAP signaling complexes: getting to the heart of the matter

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Isoform-specific differences between the type Ialpha and IIalpha cyclic AMP-dependent protein kinase anchoring domains revealed by solution NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Characterization of A-kinase-anchoring disruptors using a solution-based assay

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Molecular characterization of an anchor protein (AKAPCE) that binds the RI subunit (RCE) of type I protein kinase A from Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

AKAP79-mediated targeting of the cyclic AMP-dependent protein kinase to the beta1-adrenergic receptor promotes recycling and functional resensitization of the receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Cell-permeable peptide-based disruption of endogenous PKA-AKAP complexes: a tool for studying the molecular roles of AKAP-mediated PKA subcellular anchoring

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Disruption of protein kinase A interaction with A-kinase-anchoring proteins in the heart in vivo: effects on cardiac contractility, protein kinase A phosphorylation, and troponin I proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Direct AKAP-mediated protein-protein interactions as potential drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

AKAP-scaffolding proteins and regulation of cardiac physiology.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

A novel leucine zipper targets AKAP15 and cyclic AMP-dependent protein kinase to the C terminus of the skeletal muscle Ca2+ channel and modulates its function

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

The mAKAP signalosome and cardiac myocyte hypertrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Anchored p90 ribosomal S6 kinase 3 is required for cardiac myocyte hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.216

21 January 2018

Identifiers

DOI

10.4155/FMC.12.216

1 reference

3 August 2017

1 reference