Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance (Q34615295)

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English	Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

3 August 2017

Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance (English)

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Europe PubMed Central

PubMed publication ID

3 August 2017

type 2 diabetes

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inferred from title

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inferred from title

insulin resistance

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Claudia Langenberg

7

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Claudia Langenberg

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Deborah A. Lawlor

19

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Debbie A Lawlor

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Roger M Harbord

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Kirsten J Ward

11

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Rachel M Freathy

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Rachel M Freathy

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Tom M Palmer

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Tom Gaunt

6

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George Davey Smith

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George Davey Smith

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Timothy M Frayling

22

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Michael N Weedon

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Michael N Weedon

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Mark I McCarthy

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Nicholas J. Wareham

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Nicholas Wareham

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3 August 2017

Andrew Tym Hattersley

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Andrew T Hattersley

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3 August 2017

16

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Shah Ebrahim

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3 August 2017

Manjinder S Sandhu

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Manjinder S Sandhu

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3 August 2017

21

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Colin N A Palmer

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3 August 2017

Beverley M Shields

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Beverley Shields

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3 August 2017

Andrew D Morris

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Andrew D Morris

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3 August 2017

author name string

N Maneka G De Silva

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3 August 2017

Louise A Donnelly

4

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3 August 2017

Jian'an Luan

5

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3 August 2017

Beatrice A Knight

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3 August 2017

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publication date

31 January 2011

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3 August 2017

number of pages

11

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3 August 2017

60

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3 August 2017

3

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3 August 2017

1008-1018

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Europe PubMed Central

PubMed publication ID

3 August 2017

copyright license

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

30 August 2021

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April 2022 Public Data File from Crossref

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Biological, clinical and population relevance of 95 loci for blood lipids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Recent insights into fatty liver, metabolic dyslipidaemia and their links to insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Fatty liver and lipotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Antidiabetic action of bezafibrate in a large observational database

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Common variants at 30 loci contribute to polygenic dyslipidemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Life and death decisions of the pancreatic beta-cell: the role of fatty acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Fatty acid signaling in the beta-cell and insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Attenuation of progression of insulin resistance in patients with coronary artery disease by bezafibrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Lipoprotein lipase S447X: a naturally occurring gain-of-function mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

New insights into fatty acid modulation of pancreatic beta-cell function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

New therapeutic options for the metabolic syndrome: what's next?

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Effect of bezafibrate on incidence of type 2 diabetes mellitus in obese patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase.

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7 July 2018

Peroxisome proliferator-activated receptor ligand bezafibrate for prevention of type 2 diabetes mellitus in patients with coronary artery disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Geographical variation in cardiovascular disease, risk factors, and their control in older women: British Women's Heart and Health Study

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Pravastatin and the development of diabetes mellitus: evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

The diabetes audit and research in Tayside Scotland (DARTS) study: electronic record linkage to create a diabetes register. DARTS/MEMO Collaboration.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Prospective study of risk factors for development of non-insulin dependent diabetes in middle aged British men.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Asymptomatic hyperglycemia is associated with lipid and lipoprotein changes favoring atherosclerosis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

7 July 2018

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

26 October 2018

Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046819

26 October 2018

Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study

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Adjusting for bias and unmeasured confounding in Mendelian randomization studies with binary responses

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26 October 2018

Determinants of new-onset diabetes among 19,257 hypertensive patients randomized in the Anglo-Scandinavian Cardiac Outcomes Trial--Blood Pressure Lowering Arm and the relative influence of antihypertensive medication

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Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study

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ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis

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Use of Metabolic Markers To Identify Overweight Individuals Who Are Insulin Resistant

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26 October 2018

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

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26 October 2018

Predictors of insulin sensitivity in Type 2 diabetes mellitus.

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26 October 2018

Lipoprotein lipase gene variation is associated with a paternal history of premature coronary artery disease and fasting and postprandial plasma triglycerides: the European Atherosclerosis Research Study (EARS).

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Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat.

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Re: Estimation of Bias in Nongenetic Observational Studies Using “Mendelian Triangulation” by Bautista et al

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Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

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Increased levels of triglycerides, BMI and blood pressure and low physical activity increase the risk of diabetes in Swedish women. A prospective 18-year follow-up of the BEDA study

1 reference

https://pubmed.ncbi.nlm.nih.gov/21282362

12 December 2020

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10.2337/DB10-1317

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Europe PubMed Central

PubMed publication ID

3 August 2017

PMC publication ID

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Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

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Europe PubMed Central

PubMed publication ID

3 August 2017

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