Influence of pH on the human prion protein: insights into the early steps of misfolding (Q34590614)

3 August 2017

title

Influence of pH on the human prion protein: insights into the early steps of misfolding (English)

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3 August 2017

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Marc W van der Kamp

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Valerie Daggett

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3 August 2017

language of work or name

English

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publication date

1 October 2010

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3 August 2017

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3 August 2017

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3 August 2017

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3 August 2017

page(s)

2289-2298

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Conformational diversity in prion protein variants influences intermolecular beta-sheet formation

3 August 2017

cites work

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Distinct structures of scrapie prion protein (PrPSc)-seeded versus spontaneous recombinant prion protein fibrils revealed by hydrogen/deuterium exchange.

7 July 2018

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Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein

7 July 2018

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7 July 2018

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Crystal structure of human prion protein bound to a therapeutic antibody

7 July 2018

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7 July 2018

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Cryo-immunogold electron microscopy for prions: toward identification of a conversion site

7 July 2018

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Prion protein amyloid formation under native-like conditions involves refolding of the C-terminal alpha-helical domain

7 July 2018

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Identifying key components of the PrPC-PrPSc replicative interface

7 July 2018

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Molecular conformation and dynamics of the Y145Stop variant of human prion protein in amyloid fibrils

7 July 2018

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Molecular mechanisms of prion pathogenesis

7 July 2018

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Molecular architecture of human prion protein amyloid: a parallel, in-register beta-structure

7 July 2018

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Structural and hydration properties of the partially unfolded states of the prion protein

7 July 2018

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Beta-sheet core of human prion protein amyloid fibrils as determined by hydrogen/deuterium exchange

7 July 2018

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Structural properties of prion protein protofibrils and fibrils: an experimental assessment of atomic models

7 July 2018

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Early intermediate in human prion protein folding as evidenced by ultrarapid mixing experiments.

7 July 2018

1 reference

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Observation of intermediate states of the human prion protein by high pressure NMR spectroscopy

7 July 2018

1 reference

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Local environmental effects on the structure of the prion protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

The role of the 132-160 region in prion protein conformational transitions.

7 July 2018

1 reference

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Probing the instabilities in the dynamics of helical fragments from mouse PrPC.

7 July 2018

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From conversion to aggregation: protofibril formation of the prion protein

7 July 2018

1 reference

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The mechanism of internalization of glycosylphosphatidylinositol-anchored prion protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Influence of pH on NMR structure and stability of the human prion protein globular domain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

7 July 2018

1 reference

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Crystal structure of the human prion protein reveals a mechanism for oligomerization

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Mapping the early steps in the pH-induced conformational conversion of the prion protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Solution structure of the E200K variant of human prion protein. Implications for the mechanism of pathogenesis in familial prion diseases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

NMR structures of three single-residue variants of the human prion protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

NMR solution structure of the human prion protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Molecular dynamics simulations of human prion protein: importance of correct treatment of electrostatic interactions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Prion protein of 106 residues creates an artifical transmission barrier for prion replication in transgenic mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Prion protein NMR structure and familial human spongiform encephalopathies

7 July 2018

1 reference

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Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Theoretical studies of sequence effects on the conformational properties of a fragment of the prion protein: implications for scrapie formation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Measurement of endosome pH following folate receptor-mediated endocytosis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

NMR structure of the mouse prion protein domain PrP(121-231)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Proposed three-dimensional structure for the cellular prion protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

The interpretation of protein structures: Estimation of static accessibility

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Evidence for synthesis of scrapie prion proteins in the endocytic pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Monitoring prion protein stability by NMR.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Dynamics of a truncated prion protein, PrP(113-231), from (15)N NMR relaxation: order parameters calculated and slow conformational fluctuations localized to a distinct region

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Molecular mechanism for low pH triggered misfolding of the human prion protein

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

The determinants of stability in the human prion protein: insights into folding and misfolding from the analysis of the change in the stabilization energy distribution in different conditions

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Definable equilibrium states in the folding of human prion protein

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Annealing prion protein amyloid fibrils at high temperature results in extension of a proteinase K-resistant core.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Methods for molecular dynamics simulations of protein folding/unfolding in solution

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Simulations of biomolecules: Characterization of the early steps in the pH-induced conformational conversion of the hamster, bovine and human forms of the prion protein

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

The role of helix 1 aspartates and salt bridges in the stability and conversion of prion protein

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Acidic pH and detergents enhance in vitro conversion of human brain PrPC to a PrPSc-like form

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Cryptic epitopes in N-terminally truncated prion protein are exposed in the full-length molecule: dependence of conformation on pH.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Local structural plasticity of the prion protein. Analysis of NMR relaxation dynamics

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Novel PRNP sequence variant associated with familial encephalopathy

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

NMR characterization of the full‐length recombinant murine prion protein, mPrP(23–231)

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Neurotoxicity of a prion protein fragment

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

X-ray diffraction of scrapie prion rods and PrP peptides

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

The abnormal isoform of the prion protein accumulates in late-endosome-like organelles in scrapie-infected mouse brain

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Conformational transitions in peptides containing two putative alpha-helices of the prion protein.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Assessing the acid-base and conformational properties of histidine residues in human prion protein (125-228) by means of pKa calculations and molecular dynamics simulations

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Structural Domains and Main-Chain Flexibility in Prion Proteins†

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042553

Mouse cortical cells lacking cellular PrP survive in culture with a neurotoxic PrP fragment

9 December 2018

1 reference

12 December 2020

pH-dependent Stability and Conformation of the Recombinant Human Prion Protein PrP(90–231)

1 reference

12 December 2020

Multiple folding pathways for heterologously expressed human prion protein

1 reference

12 December 2020

Identification of pH-sensitive regions in the mouse prion by the cysteine-scanning spin-labeling ESR technique

1 reference

12 December 2020

Production and Characterization of a Panel of Monoclonal Antibodies Against Native Human Cellular Prion Protein

1 reference

12 December 2020

10.1016/J.BPJ.2010.07.063

Identifiers

DOI

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3 August 2017

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3 August 2017

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