In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons (Q34597796)

3 August 2017

title

In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons (English)

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3 August 2017

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Daniel H Geschwind

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3 August 2017

Ruth Luthi-Carter

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3 August 2017

Elizabeth A Thomas

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3 August 2017

Giovanni Coppola

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3 August 2017

Bin Tang

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3 August 2017

Alexandre Kuhn

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3 August 2017

SoongHo Kim

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3 August 2017

Timothy B Brown

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3 August 2017

Michelle E Ehrlich

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3 August 2017

publication date

20 December 2010

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3 August 2017

published in

Human Molecular Genetics

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3 August 2017

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3 August 2017

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3 August 2017

page(s)

1049-1060

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describes a project that uses

3 August 2017

limma

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22 June 2022

https://europepmc.org/article/PMC/3043657

based on heuristic

inferred from PubMed Central ID database lookup

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Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

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7 July 2018

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Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry.

26 October 2018

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Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

26 October 2018

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26 October 2018

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Dopamine release is severely compromised in the R6/2 mouse model of Huntington's disease

26 October 2018

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Selective deficits in the expression of striatal-enriched mRNAs in Huntington's disease.

26 October 2018

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26 October 2018

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26 October 2018

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Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum

26 October 2018

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Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses

26 October 2018

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Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

26 October 2018

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Expression of the striatal DARPP-32/ARPP-21 phenotype in GABAergic neurons requires neurotrophins in vivo and in vitro.

26 October 2018

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Chemical anatomy of striatal interneurons in normal individuals and in patients with Huntington's disease

26 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21177255

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDQ548

1 reference

3 August 2017

1 reference

3 August 2017

1 reference