Functional pathway analysis using SCNP of FLT3 receptor pathway deregulation in AML provides prognostic information independent from mutational status (Q34595162)

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English	Functional pathway analysis using SCNP of FLT3 receptor pathway deregulation in AML provides prognostic information independent from mutational status	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

3 August 2017

Functional pathway analysis using SCNP of FLT3 receptor pathway deregulation in AML provides prognostic information independent from mutational status (English)

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Europe PubMed Central

PubMed publication ID

3 August 2017

pathway analysis

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based on heuristic

inferred from title

Martin S. Tallman

11

object named as

Martin S Tallman

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Europe PubMed Central

PubMed publication ID

3 August 2017

Elisabeth Paietta

12

object named as

Elisabeth Paietta

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PubMed publication ID

3 August 2017

author name string

Alessandra Cesano

1

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Europe PubMed Central

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3 August 2017

Santosh Putta

2

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3 August 2017

David B Rosen

3

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PubMed publication ID

3 August 2017

Aileen C Cohen

4

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Europe PubMed Central

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3 August 2017

Urte Gayko

5

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Europe PubMed Central

PubMed publication ID

3 August 2017

Kavita Mathi

6

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Europe PubMed Central

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3 August 2017

John Woronicz

7

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Europe PubMed Central

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3 August 2017

Rachael E Hawtin

8

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3 August 2017

Larry Cripe

9

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3 August 2017

Zhuoxin Sun

10

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3 August 2017

language of work or name

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publication date

19 February 2013

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Europe PubMed Central

PubMed publication ID

3 August 2017

8

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Europe PubMed Central

PubMed publication ID

3 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

e56714

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Europe PubMed Central

PubMed publication ID

3 August 2017

copyright license

Creative Commons Attribution 4.0 International

19 February 2013

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April 2022 Public Data File from Crossref

copyright status

0 references

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

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Functional pathway analysis in acute myeloid leukemia using single cell network profiling assay: effect of specimen source (bone marrow or peripheral blood) on assay readouts

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Prognostic impact of FLT3-ITD load in NPM1 mutated acute myeloid leukemia

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Hallmarks of Cancer: The Next Generation

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Functional characterization of FLT3 receptor signaling deregulation in acute myeloid leukemia by single cell network profiling (SCNP).

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Distinct patterns of DNA damage response and apoptosis correlate with Jak/Stat and PI3kinase response profiles in human acute myelogenous leukemia

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Cells expressing FLT3/ITD mutations exhibit elevated repair errors generated through alternative NHEJ pathways: implications for genomic instability and therapy

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FLT3 as a therapeutic target in AML: still challenging after all these years

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Dynamic single-cell network profiles in acute myelogenous leukemia are associated with patient response to standard induction therapy

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7 July 2018

Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B study

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7 July 2018

Deregulation of signaling pathways in acute myeloid leukemia

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576376

7 July 2018

Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML.

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7 July 2018

Toward quantitative fluorescence measurements with multicolor flow cytometry

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7 July 2018

The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia

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7 July 2018

Hematopoietic cytokine receptor signaling

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7 July 2018

STAT5 signaling in normal and pathologic hematopoiesis

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A standardized ZAP-70 assay--lessons learned in the trenches

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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

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7 July 2018

Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML).

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7 July 2018

Signal transduction of oncogenic Flt3.

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7 July 2018

No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML10 and 12 trials.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576376

7 July 2018

Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

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7 July 2018

A phase 3 study of three induction regimens and of priming with GM-CSF in older adults with acute myeloid leukemia: a trial by the Eastern Cooperative Oncology Group

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7 July 2018

Signal transducer and activator of transcription proteins in leukemias.

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7 July 2018

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576376

7 July 2018

Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study.

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7 July 2018

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576376

7 July 2018

The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial

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7 July 2018

Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3576376

7 July 2018

Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling

1 reference

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7 July 2018

Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells

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7 July 2018

FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates

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c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities

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Substrate specificities and identification of a putative binding site for PI3K in the carboxy tail of the murine Flt3 receptor tyrosine kinase

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Mitogenic Signalling and Substrate Specificity of the Flk2/Flt3 Receptor Tyrosine Kinase in Fibroblasts and Interleukin 3-Dependent Hematopoietic Cells

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7 July 2018

Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm.

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FLT3 mutation and response to intensive chemotherapy in young adult and elderly patients with normal karyotype

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Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival

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Quantitative assessment of minimal residual disease in acute myeloid leukemia carrying nucleophosmin (NPM1) gene mutations.

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Pediatric AML primary samples with FLT3/ITD mutations are preferentially killed by FLT3 inhibition

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Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.

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Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

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Phosphatase and tensin homologue phosphorylation in the C-terminal regulatory domain is frequently observed in acute myeloid leukaemia and associated with poor clinical outcome

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Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia. The Children's Cancer and Leukemia Study Group, Japan

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Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia

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Tyrosine kinases as targets for cancer therapy

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Prognostic value of internal tandem duplication of the FLT3 gene in childhood acute myelogenous leukemia

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https://pubmed.ncbi.nlm.nih.gov/23431389

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Identifiers

10.1371/JOURNAL.PONE.0056714

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

2013PLoSO...856714C

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

ResearchGate publication ID

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