The critical role of GRP78 in physiologic and pathologic stress. (Q34594217)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20970977%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

title

The critical role of GRP78 in physiologic and pathologic stress (English)

1 reference

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16 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20970977%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Kyle T Pfaffenbach

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16 February 2020

publication date

21 October 2010

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20970977%20AND%20SRC:MED&resulttype=core&format=json

Current Opinion in Cell Biology

16 February 2020

published in

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16 February 2020

volume

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16 February 2020

issue

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16 February 2020

page(s)

150-156

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20970977%20AND%20SRC:MED&resulttype=core&format=json

Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis

16 February 2020

cites work

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Insulin modulates induction of glucose‐regulated protein 78 during endoplasmic reticulum stress via augmentation of ATF4 expression in human neuroblastoma cells

7 July 2018

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A Phos-tag-based approach reveals the extent of physiological endoplasmic reticulum stress

7 July 2018

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Akt is the downstream target of GRP78 in mediating cisplatin resistance in ER stress-tolerant human lung cancer cells

7 July 2018

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Targeting GRP78 to enhance melanoma cell death.

7 July 2018

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GRP78 as potential predictor for breast cancer response to adjuvant taxane therapy

7 July 2018

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Endoplasmic reticulum stress: a new actor in the development of hepatic steatosis.

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Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity

7 July 2018

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Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells

7 July 2018

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The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

7 July 2018

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A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response

7 July 2018

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Rapamycin inhibits postprandial-mediated X-box-binding protein-1 splicing in rat liver

7 July 2018

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Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP.

7 July 2018

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Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78.

7 July 2018

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Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance

7 July 2018

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p28GANK inhibits endoplasmic reticulum stress-induced cell death via enhancement of the endoplasmic reticulum adaptive capacity

7 July 2018

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GRP-78 secreted by tumor cells blocks the antiangiogenic activity of bortezomib

7 July 2018

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The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis

7 July 2018

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Plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: sensitization by radiation and requirement for GRP78 and LRP1.

7 July 2018

1 reference

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Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways

7 July 2018

1 reference

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Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis

7 July 2018

1 reference

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GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice

7 July 2018

1 reference

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Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss

7 July 2018

1 reference

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Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043145

Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells

7 July 2018

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Aging impairs the unfolded protein response to sleep deprivation and leads to proapoptotic signaling

7 July 2018

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Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum.

7 July 2018

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The role for endoplasmic reticulum stress in diabetes mellitus

7 July 2018

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Decreased enzyme activities of chaperones PDI and BiP in aged mouse livers

7 July 2018

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GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth

7 July 2018

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The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.

7 July 2018

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Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival.

7 July 2018

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ER chaperones in mammalian development and human diseases

7 July 2018

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GRP78 induction in cancer: therapeutic and prognostic implications.

7 July 2018

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Mechanistic studies of a peptidic GRP78 ligand for cancer cell-specific drug delivery

7 July 2018

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Prostate cancer cell proliferation in vitro is modulated by antibodies against glucose-regulated protein 78 isolated from patient serum

7 July 2018

1 reference

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Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer

7 July 2018

1 reference

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Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043145

GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043145

GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043145

The effect of aging on the chaperone concentrations in the hepatic, endoplasmic reticulum of male rats: the possible role of protein misfolding due to the loss of chaperones in the decline in physiological function seen with age

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043145

Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043145

Stress induction of GRP78/BiP and its role in cancer.

7 July 2018

1 reference

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From acute ER stress to physiological roles of the Unfolded Protein Response

7 July 2018

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Cellular environment facilitates protein accumulation in aged rat hippocampus.

7 July 2018

1 reference

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A trip to the ER: coping with stress

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043145

Expression of glucose-regulated stress protein GRP78 is related to progression of melanoma.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3043145

Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders.

27 October 2018

1 reference

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Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development.

27 October 2018

1 reference

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The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress

27 October 2018

1 reference

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Transgenic mouse model for monitoring endoplasmic reticulum stress in vivo

27 October 2018

1 reference

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Carbonylation of ER chaperone proteins in aged mouse liver

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20970977

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20970977

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CEB.2010.09.007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20970977%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20970977%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

PubMed publication ID

20970977

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20970977%20AND%20SRC:MED&resulttype=core&format=json