Loss of p53 impedes the antileukemic response to BCR-ABL inhibition (Q34585293)

3 August 2017

title

Loss of p53 impedes the antileukemic response to BCR-ABL inhibition (English)

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3 August 2017

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3 August 2017

Elisa de Stanchina

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Andreas Hochhaus

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Hans-Guido Wendel

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3 August 2017

Enriqué Cepero

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3 August 2017

Sagarika Ray

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3 August 2017

Michael Emig

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3 August 2017

Jordan S Fridman

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3 August 2017

Darren R Veach

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3 August 2017

William G Bornmann

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3 August 2017

Bayard Clarkson

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3 August 2017

Scott C Kogan

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3 August 2017

Scott W Lowe

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3 August 2017

language of work or name

English

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publication date

1 May 2006

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Proceedings of the National Academy of Sciences of the United States of America

3 August 2017

published in

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3 August 2017

volume

103

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3 August 2017

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3 August 2017

page(s)

7444-7449

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Tyrosine kinase inhibitor STI571 (Imatinib) cooperates with wild-type p53 on K562 cell line to enhance its proapoptotic effects

3 August 2017

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7 July 2018

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Intrinsic tumour suppression

7 July 2018

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Treatment of chronic myeloid leukemia cells with imatinib (STI571) impairs p53 accumulation in response to DNA damage

7 July 2018

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Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the p(210)BCR-ABL tyrosine kinase

7 July 2018

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BCR/ABL activates mdm2 mRNA translation via the La antigen

7 July 2018

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Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis

7 July 2018

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Cancer. Addiction to oncogenes--the Achilles heal of cancer

7 July 2018

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Dissecting p53 tumor suppressor functions in vivo

7 July 2018

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Requirement for Mdm2 in the survival effects of Bcr-Abl and interleukin 3 in hematopoietic cells

7 July 2018

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

7 July 2018

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

7 July 2018

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Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

7 July 2018

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Acquired loss of p53 induces blastic transformation in p210(bcr/abl)-expressing hematopoietic cells: a transgenic study for blast crisis of human CML.

7 July 2018

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Mutation of Tp53 contributes to the malignant phenotype of Abelson virus-transformed lymphoid cells

7 July 2018

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Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

7 July 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

7 July 2018

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Chromosome 17 abnormalities and inactivation of the p53 gene in chronic myeloid leukemia and their prognostic significance

7 July 2018

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Cell cycle control and cancer

7 July 2018

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Mapping of the p53 and mdm-2 Interaction Domains

7 July 2018

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Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia

7 July 2018

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Rearrangements in the p53 gene in Philadelphia chromosome positive chronic myelogenous leukemia.

7 July 2018

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p53 in chronic myelogenous leukemia in acute phase

7 July 2018

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Rearrangement and expression of p53 in the chronic phase and blast crisis of chronic myelogenous leukemia.

7 July 2018

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Response and resistance in 300 patients with BCR-ABL-positive leukemias treated with imatinib in a single center: a 4.5-year follow-up

7 July 2018

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BCR-ABL kinase domain mutations in chronic myeloid leukemia: not quite enough to cause resistance to imatinib therapy?

21 January 2018

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Establishment of a murine model for therapy-treated chronic myelogenous leukemia using the tyrosine kinase inhibitor STI571.

21 January 2018

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Treatment of Chronic Myeloid Leukemia Cells with Imatinib (STI571) Impairs p53 Accumulation in Response to DNA Damage

21 January 2018

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Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow

21 January 2018

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12 December 2020

Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice

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12 December 2020

Interest of investigating p53 status in breast cancer by four different methods

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12 December 2020

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

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12 December 2020

TP53 codon 72 polymorphism in patients with chronic myeloid leukemia

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0602402103

1 reference

3 August 2017

0 references

1 reference

3 August 2017

1 reference