Mechanism-based inactivation of human cytochrome P450 3A4 by two piperazine-containing compounds (Q34575026)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25273356%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

Mechanism-based inactivation of human cytochrome P450 3A4 by two piperazine-containing compounds (English)

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20 February 2020

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20 February 2020

Amanda K Bolles

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20 February 2020

Rina Fujiwara

series ordinal

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20 February 2020

Erran D Briggs

series ordinal

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20 February 2020

Amin A Nomeir

series ordinal

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20 February 2020

language of work or name

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1 October 2014

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Drug Metabolism and Disposition

20 February 2020

published in

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20 February 2020

volume

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20 February 2020

issue

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20 February 2020

page(s)

2087-2096

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Metoclopramide is metabolized by CYP2D6 and is a reversible inhibitor, but not inactivator, of CYP2D6

20 February 2020

cites work

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Identification of the residue in human CYP3A4 that is covalently modified by bergamottin and the reactive intermediate that contributes to the grapefruit juice effect

7 July 2018

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7 July 2018

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Mechanism-based inactivation of human cytochrome P450 2B6 by clopidogrel: involvement of both covalent modification of cysteinyl residue 475 and loss of heme

7 July 2018

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Substituted Imidazole of 5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates Cytochrome P450 2D6 by Protein Adduction

7 July 2018

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Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir

7 July 2018

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Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib

7 July 2018

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Mechanism-based inactivation of CYP2B1 and its F-helix mutant by two tert-butyl acetylenic compounds: covalent modification of prosthetic heme versus apoprotein

7 July 2018

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7 July 2018

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Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implications

7 July 2018

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A semiempirical free energy force field with charge-based desolvation

7 July 2018

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Structural basis for ligand promiscuity in cytochrome P450 3A4.

7 July 2018

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Crystal structure of human cytochrome P450 2D6

7 July 2018

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Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs.

7 July 2018

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7 July 2018

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Cytochromes P450, drugs, and diseases

7 July 2018

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Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation

7 July 2018

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Mechanism-based inactivation of cytochrome P450 2B1 by 7-ethynylcoumarin: verification of apo-P450 adduction by electrospray ion trap mass spectrometry

7 July 2018

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Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice

7 July 2018

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Structural analysis of the FMN binding domain of NADPH-cytochrome P-450 oxidoreductase by site-directed mutagenesis

7 July 2018

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Cytochrome p450 architecture and cysteine nucleophile placement impact raloxifene-mediated mechanism-based inactivation

7 July 2018

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Predicting drug metabolism by cytochrome P450 2C9: comparison with the 2D6 and 3A4 isoforms

27 October 2018

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Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme

27 October 2018

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Time-dependent inactivation of P450 3A4 by raloxifene: identification of Cys239 as the site of apoprotein alkylation

27 October 2018

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The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5.

27 October 2018

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27 October 2018

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27 October 2018

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27 October 2018

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27 October 2018

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27 October 2018

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27 October 2018

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Mechanism-based inactivation of cytochrome P450 3A4 by 17 alpha-ethynylestradiol: evidence for heme destruction and covalent binding to protein

27 October 2018

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Mechanism-based inactivation of CYP2D6 by 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine

27 October 2018

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Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme.

27 October 2018

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Detection of covalent adducts to cytochrome P450 3A4 using liquid chromatography mass spectrometry

27 October 2018

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12 December 2020

Partitioning between N-dealkylation and N-oxygenation in the oxidation of N,N-dialkylarylamines catalyzed by cytochrome P450 2B1

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12 December 2020

The high-level expression in Escherichia coli of the membrane-bound form of human and rat cytochrome b5 and studies on their mechanism of function

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12 December 2020

Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities

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12 December 2020

Identification of cytochrome P450 3A4 modification site with reactive metabolite using linear ion trap-Fourier transform mass spectrometry

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12 December 2020

Identifiers

DOI

10.1124/DMD.114.060459

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25273356%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

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20 February 2020

PubMed publication ID

25273356

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25273356%20AND%20SRC:MED&resulttype=core&format=json