Functional interactions between P-glycoprotein and CYP3A in drug metabolism (Q34550483)

3 August 2017

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title

Functional interactions between P-glycoprotein and CYP3A in drug metabolism (English)

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3 August 2017

Uwe Christians

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3 August 2017

Volker Schmitz

series ordinal

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3 August 2017

Manuel Haschke

series ordinal

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3 August 2017

language of work or name

English

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publication date

1 December 2005

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Expert Opinion on Drug Metabolism & Toxicology

3 August 2017

published in

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3 August 2017

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3 August 2017

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3 August 2017

page(s)

641-654

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Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

3 August 2017

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21 January 2018

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Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism

21 January 2018

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In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5.

21 January 2018

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Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

21 January 2018

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Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA.

21 January 2018

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Biochemistry of multidrug resistance mediated by the multidrug transporter

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

21 January 2018

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

21 January 2018

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Induction of phase I, II and III drug metabolism/transport by xenobiotics

21 January 2018

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Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system

21 January 2018

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Transport proteins and intestinal metabolism: P-glycoprotein and cytochrome P4503A.

21 January 2018

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Unmasking the dynamic interplay between efflux transporters and metabolic enzymes.

21 January 2018

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Transporter-Enzyme Interactions: Implications for Predicting Drug-Drug Interactions from In Vitro Data

21 January 2018

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The drug efflux-metabolism alliance: biochemical aspects.

21 January 2018

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Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4.

21 January 2018

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CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam

21 January 2018

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Application of compartmental modeling to an examination of in vitro intestinal permeability data: assessing the impact of tissue uptake, P-glycoprotein, and CYP3A.

21 January 2018

1 reference

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In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model

21 January 2018

1 reference

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Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber

21 January 2018

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Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers

21 January 2018

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Mapping of multidrug resistance gene 1 and multidrug resistance-associated protein isoform 1 to 5 mRNA expression along the human intestinal tract

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Relevance of p-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.1.4.641

The small intestine as a xenobiotic-metabolizing organ

21 January 2018

1 reference

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Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine, and gg918.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Beyond the human genome: examples of nuclear receptor analysis in model organisms and potential for drug discovery

21 January 2018

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Nuclear receptors and the control of metabolism

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.1.4.641

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

21 January 2018

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Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR.

21 January 2018

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Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor

21 January 2018

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The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Genetic contribution to variable human CYP3A-mediated metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Clinical aspects of the MDR1 (ABCB1) gene polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Pharmacogenetics in solid organ transplantation: present knowledge and future perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Tacrolimus pharmacogenetics: polymorphisms associated with expression of cytochrome p4503A5 and P-glycoprotein correlate with dose requirement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

CYP3A5*1-carrying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

MDR-1 C3435T polymorphism influences cyclosporine a dose requirement in liver-transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Consequences of genetic polymorphisms for sirolimus requirements after renal transplant in patients on primary sirolimus therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Pharmacogenomics of immunosuppressive drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Pharmacogenetics in pediatrics. Implications for practice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Sex is a major determinant of CYP3A4 expression in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Do men and women differ in proximal small intestinal CYP3A or P-glycoprotein expression?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Drug-drug, drug-dietary supplement, and drug-citrus fruit and other food interactions: what have we learned?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Dietary Effects on Drug Metabolism and Transport

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Herbal modulation of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Regulation of cytochromes P450 during inflammation and infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Modulation of drug metabolism in infectious and inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Cyclosporin metabolism in transplant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Effect of hepatitis C infection on tacrolimus doses and blood levels in liver transplantation recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.4.641

21 January 2018

Identifiers

DOI

10.1517/17425255.1.4.641

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3 August 2017

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