PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D. (Q34554022)

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13 March 2020

title

PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D (English)

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13 March 2020

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13 March 2020

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13 March 2020

Hatice Ülkü Osmanbeyoğlu

series ordinal

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13 March 2020

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13 March 2020

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13 March 2020

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13 March 2020

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13 March 2020

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13 March 2020

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13 March 2020

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13 March 2020

Maura N Dickler

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13 March 2020

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language of work or name

English

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publication date

1 March 2017

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13 March 2020

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13 March 2020

volume

355

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issue

6331

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13 March 2020

page(s)

1324-1330

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FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.

13 March 2020

cites work

1 reference

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PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer

7 July 2018

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Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

7 July 2018

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Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis.

7 July 2018

1 reference

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PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer

7 July 2018

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Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer

7 July 2018

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Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor

7 July 2018

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Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials

7 July 2018

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Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

7 July 2018

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The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers

7 July 2018

1 reference

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Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer

7 July 2018

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Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4

7 July 2018

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EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

7 July 2018

1 reference

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Comprehensive molecular portraits of human breast tumours

7 July 2018

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The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis

7 July 2018

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Molecular mechanisms and potential functions of histone demethylases

7 July 2018

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PBX1 genomic pioneer function drives ERα signaling underlying progression in breast cancer.

7 July 2018

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DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5485411

FOXA1 is a key determinant of estrogen receptor function and endocrine response

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5485411

The nuts and bolts of AGC protein kinases

7 July 2018

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Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers

7 July 2018

1 reference

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FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription

7 July 2018

1 reference

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Identification of the MLL2 complex as a coactivator for estrogen receptor alpha

7 July 2018

1 reference

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Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3

7 July 2018

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A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-Specific Inhibitor, with Letrozole in ER+/HER2- Metastatic Breast Cancer

7 July 2018

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Oestrogen-receptor-mediated transcription and the influence of co-factors and chromatin state

21 January 2018

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The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells

21 January 2018

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Examination of micro-tip reversed-phase liquid chromatographic extraction of peptide pools for mass spectrometric analysis

21 January 2018

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21 January 2018

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STAR: ultrafast universal RNA-seq aligner

21 January 2018

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Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

21 January 2018

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Model-based analysis of ChIP-Seq (MACS)

21 January 2018

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21 January 2018

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ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data

21 January 2018

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Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1126/SCIENCE.AAH6893

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28336670%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

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13 March 2020

PubMed publication ID

28336670

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28336670%20AND%20SRC:MED&resulttype=core&format=json