Structural and molecular interactions of CCR5 inhibitors with CCR5. (Q34494226)

2 August 2017

title

Structural and molecular interactions of CCR5 inhibitors with CCR5. (English)

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2 August 2017

main subject

molecular interaction

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Eddy Arnold

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2 August 2017

Kenji Maeda

1 reference

2 August 2017

Debananda Das

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2 August 2017

Hiromi Ogata-Aoki

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2 August 2017

Hirotomo Nakata

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2 August 2017

Toshikazu Miyakawa

1 reference

2 August 2017

Yasushi Tojo

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2 August 2017

Rachael Norman

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2 August 2017

Yoshikazu Takaoka

1 reference

2 August 2017

Jianping Ding

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2 August 2017

Gail F Arnold

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2 August 2017

Hiroaki Mitsuya

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2 August 2017

language of work or name

English

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publication date

13 February 2006

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Journal of Biological Chemistry

2 August 2017

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inferred from page(s)

published in

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2 August 2017

volume

281

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2 August 2017

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2 August 2017

page(s)

12688-12698

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HIV and AIDS: 20 years of science

2 August 2017

cites work

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21 January 2018

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CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5.

21 January 2018

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Spirodiketopiperazine-based CCR5 inhibitor which preserves CC-chemokine/CCR5 interactions and exerts potent activity against R5 human immunodeficiency virus type 1 in vitro

21 January 2018

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Potent anti-R5 human immunodeficiency virus type 1 effects of a CCR5 antagonist, AK602/ONO4128/GW873140, in a novel human peripheral blood mononuclear cell nonobese diabetic-SCID, interleukin-2 receptor gamma-chain-knocked-out AIDS mouse model.

21 January 2018

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A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

21 January 2018

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SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo

21 January 2018

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Involvement of both the V2 and V3 regions of the CCR5-tropic human immunodeficiency virus type 1 envelope in reduced sensitivity to macrophage inflammatory protein 1alpha

21 January 2018

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A critical site in the core of the CCR5 chemokine receptor required for binding and infectivity of human immunodeficiency virus type 1.

21 January 2018

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Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding

21 January 2018

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Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function

21 January 2018

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Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance

21 January 2018

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Crystal structure of rhodopsin: A G protein-coupled receptor

21 January 2018

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Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening

21 January 2018

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Extending the accuracy limits of prediction for side-chain conformations

21 January 2018

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Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

21 January 2018

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A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

21 January 2018

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Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry.

21 January 2018

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Molecular anatomy of CCR5 engagement by physiologic and viral chemokines and HIV-1 envelope glycoproteins: differences in primary structural requirements for RANTES, MIP-1 alpha, and vMIP-II Binding

21 January 2018

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Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity

21 January 2018

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Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3.

21 January 2018

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Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases

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Atomic physicochemical parameters for three dimensional structure directed quantitative structure-activity relationships. 4. Additional parameters for hydrophobic and dispersive interactions and their application for an automated superposition of ...

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COCI

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12 September 2021

Identifiers

DOI

10.1074/JBC.M512688200

1 reference

release_d6fqkihtb5dzdgh6foibr57gn4

2 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/d6fqkihtb5dzdgh6foibr57gn4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference