Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex (Q34472032)

2 August 2017

title

Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex (English)

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2 August 2017

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Hiroko Sugiura

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2 August 2017

Shin Yasuda

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2 August 2017

Shutaro Katsurabayashi

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2 August 2017

Hiroyuki Kawano

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2 August 2017

Kentaro Endo

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2 August 2017

Kotaro Takasaki

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2 August 2017

Katsunori Iwasaki

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2 August 2017

Masumi Ichikawa

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2 August 2017

Toshiyuki Kobayashi

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2 August 2017

Okio Hino

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2 August 2017

Kanato Yamagata

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2 August 2017

language of work or name

English

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publication date

16 April 2015

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2 August 2017

published in

Nature Communications

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2 August 2017

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2 August 2017

page(s)

6842

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From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome

2 August 2017

cites work

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Dendritic spine formation and synaptic function require neurobeachin.

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The tuberous sclerosis complex

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Linkage of an important gene locus for tuberous sclerosis to a chromosome 16 marker for polycystic kidney disease

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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Rheb1 is required for mTORC1 and myelination in postnatal brain development

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Rheb fills a GAP between TSC and TOR.

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Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex

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Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons

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Syndecan-2 induces filopodia and dendritic spine formation via the neurofibromin-PKA-Ena/VASP pathway

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PIP(2)-PDZ domain binding controls the association of syntenin with the plasma membrane

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Syntenin is involved in the developmental regulation of neuronal membrane architecture

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The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1.

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Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene

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Activity-dependent growth of new dendritic spines is regulated by the proteasome

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Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells

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A dual shaping mechanism for postsynaptic ephrin-B3 as a receptor that sculpts dendrites and synapses.

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Trans-synaptic EphB2-ephrin-B3 interaction regulates excitatory synapse density by inhibition of postsynaptic MAPK signaling

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Postsynaptic ephrinB3 promotes shaft glutamatergic synapse formation.

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ERK1/2 activation is necessary for BDNF to increase dendritic spine density in hippocampal CA1 pyramidal neurons.

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Ephrin-B1 and ephrin-B2 mediate EphB-dependent presynaptic development via syntenin-1.

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Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis

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SynCAM, a synaptic adhesion molecule that drives synapse assembly

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The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity

21 January 2018

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Different binding motifs in metabotropic glutamate receptor type 7b for filamin A, protein phosphatase 1C, protein interacting with protein kinase C (PICK) 1 and syntenin allow the formation of multimeric protein complexes

21 January 2018

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A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival

21 January 2018

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21 January 2018

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21 January 2018

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Rheb binds and regulates the mTOR kinase

21 January 2018

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Inhibitory role of endophilin 3 in receptor-mediated endocytosis

21 January 2018

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Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases

21 January 2018

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A shared vesicular carrier allows synaptic corelease of GABA and glycine

21 January 2018

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The effects of temperature on vesicular supply and release in autaptic cultures of rat and mouse hippocampal neurons

21 January 2018

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Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?

21 January 2018

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CASK and protein 4.1 support F-actin nucleation on neurexins

21 January 2018

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7 January 2021

Spine formation and correlated assembly of presynaptic and postsynaptic molecules.

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https://api.crossref.org/works/10.1038%2FNCOMMS7842

7 January 2021

CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins

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7 January 2021

Analysis of neurotransmitter release mechanisms by photolysis of caged Ca²⁺ in an autaptic neuron culture system

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https://api.crossref.org/works/10.1038%2FNCOMMS7842

7 January 2021

Identifiers

DOI

10.1038/NCOMMS7842

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Dimensions Publication ID

2 August 2017

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1016387661

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1 reference