Rapamycin-induced metabolic defects are reversible in both lean and obese mice (Q34461128)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25324470%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

title

Rapamycin-induced metabolic defects are reversible in both lean and obese mice (English)

1 reference

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21 February 2020

0 references

1 reference

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21 February 2020

Arlan Richardson

1 reference

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21 February 2020

Yuhong Liu

1 reference

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21 February 2020

Vivian Diaz

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21 February 2020

Elizabeth Fernandez

1 reference

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21 February 2020

Randy Strong

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21 February 2020

Lan Ye

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21 February 2020

Joseph A Baur

1 reference

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21 February 2020

Adam B Salmon

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21 February 2020

publication date

1 September 2014

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21 February 2020

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21 February 2020

volume

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21 February 2020

issue

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21 February 2020

page(s)

742-754

1 reference

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Male mice retain a metabolic memory of improved glucose tolerance induced during adult onset, short-term dietary restriction

21 February 2020

cites work

1 reference

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Evidence of a metabolic memory to early-life dietary restriction in male C57BL/6 mice

6 July 2018

1 reference

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Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet

6 July 2018

1 reference

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Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome

6 July 2018

1 reference

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Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

6 July 2018

1 reference

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mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome

6 July 2018

1 reference

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Rapamycin extends murine lifespan but has limited effects on aging

6 July 2018

1 reference

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Late-life rapamycin treatment reverses age-related heart dysfunction.

6 July 2018

1 reference

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Rapamycin extends life and health in C57BL/6 mice

6 July 2018

1 reference

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Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.

6 July 2018

1 reference

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Duration of rapamycin treatment has differential effects on metabolism in mice

6 July 2018

1 reference

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Rapalogs and mTOR inhibitors as anti-aging therapeutics

6 July 2018

1 reference

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Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet

6 July 2018

1 reference

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The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue

6 July 2018

1 reference

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New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis

6 July 2018

1 reference

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Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2.

6 July 2018

1 reference

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Rapamycin slows aging in mice

6 July 2018

1 reference

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Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice

6 July 2018

1 reference

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mTOR signaling in growth control and disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221917

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221917

Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity

6 July 2018

1 reference

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Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats

6 July 2018

1 reference

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mTORC1 inhibition via rapamycin promotes triacylglycerol lipolysis and release of free fatty acids in 3T3-L1 adipocytes.

6 July 2018

1 reference

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Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221917

Rapamycin extends maximal lifespan in cancer-prone mice

6 July 2018

1 reference

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Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism

6 July 2018

1 reference

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Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue

6 July 2018

1 reference

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Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage

6 July 2018

1 reference

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mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

6 July 2018

1 reference

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

6 July 2018

1 reference

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mTOR complex 2 in adipose tissue negatively controls whole-body growth

6 July 2018

1 reference

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Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration

6 July 2018

1 reference

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Sirolimus is associated with new-onset diabetes in kidney transplant recipients.

6 July 2018

1 reference

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mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

6 July 2018

1 reference

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Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

6 July 2018

1 reference

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Hypothalamic mTOR signaling regulates food intake

6 July 2018

1 reference

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221917

Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221917

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221917

Temporal linkage between the phenotypic and genomic responses to caloric restriction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221917

Rapamycin inhibits human adipocyte differentiation in primary culture

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221917

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221917

PPARγ activation attenuates glucose intolerance induced by mTOR inhibition with rapamycin in rats.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221917

Long-term administration of rapamycin reduces adiposity, but impairs glucose tolerance in high-fat diet-fed KK/HlJ mice.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221917

Rapamycin protects against high fat diet-induced obesity in C57BL/6J mice

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221917

mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221917

Glucose metabolism in renal transplant recipients: effect of calcineurin inhibitor withdrawal and conversion to sirolimus

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221917

Reversible effects of long-term caloric restriction on protein oxidative damage

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25324470

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/AGING.100688

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25324470%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25324470%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

PubMed publication ID

25324470

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25324470%20AND%20SRC:MED&resulttype=core&format=json