Thrombopoietin: a pan-hematopoietic cytokine (Q34467090)

2 August 2017

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title

Thrombopoietin: a pan-hematopoietic cytokine (English)

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2 August 2017

Amy E Geddis

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2 August 2017

Hannah M Linden

series ordinal

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2 August 2017

Kenneth Kaushansky

series ordinal

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2 August 2017

publication date

1 February 2002

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Cytokine and Growth Factor Reviews

2 August 2017

published in

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2 August 2017

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2 August 2017

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2 August 2017

page(s)

61-73

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MPLV: a retrovirus complex inducing an acute myeloproliferative leukemic disorder in adult mice

2 August 2017

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The hematopoietin receptor superfamily

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Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl.

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The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production

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Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

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Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer

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Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin

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7 January 2021

Recombinant human megakaryocyte growth and development factor (rHuMGDF), a ligand for c-Mpl, produces functional human platelets in vitro

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Kinetics of endomitosis in primary murine megakaryocytes

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Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor.

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Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy

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Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy-induced thrombocytopenia.

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c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia

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Sustained ex vivo expansion of hematopoietic stem cells mediated by thrombopoietin

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Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets

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Interaction of thrombopoietin with the platelet c-mpl receptor in plasma: binding, internalization, stability and pharmacokinetics

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7 January 2021

Analysis of the kinetics of TPO uptake during platelet transfusion

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7 January 2021

Circulating thrombopoietin level in chronic immune thrombocytopenic purpura

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7 January 2021

Circulating levels of thrombopoietic and inflammatory cytokines in patients with clonal and reactive thrombocytosis

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7 January 2021

Circulating thrombopoietin in reactive conditions behaves like an acute phase reactant

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7 January 2021

High levels of thrombopoietin in sera of patients with essential thrombocythemia: cause or consequence of abnormal platelet production?

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Serum thrombopoietin concentration and peripheral platelet counts in essential thrombocythemia

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7 January 2021

An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia

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7 January 2021

Hereditary thrombocythaemia in a Japanese family is caused by a novel point mutation in the thrombopoietin gene

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7 January 2021

Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation

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7 January 2021

The crystal structure of affinity-matured human growth hormone at 2 A resolution

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7 January 2021

The glycan domain of thrombopoietin enhances its secretion

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7 January 2021

Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from ser1 to Arg246.

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7 January 2021

Functional analysis of the C-terminal region of recombinant human thrombopoietin. C-terminal region of thrombopoietin is a "shuttle" peptide to help secretion

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7 January 2021

Mutational Analysis of Thrombopoietin for Identification of Receptor and Neutralizing Antibody Sites

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7 January 2021

Identification of Functionally Important Residues of Human Thrombopoietin

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7 January 2021

A model of the complex between interleukin-4 and its receptors

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7 January 2021

Role of carbohydrate modification in the production and secretion of human granulocyte macrophage colony-stimulating factor in genetically engineered and normal mesenchymal cells

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7 January 2021

A model for the interaction of the GM-CSF, IL-3 and IL-5 receptors with their ligands

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7 January 2021

Structural design and molecular evolution of a cytokine receptor superfamily

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7 January 2021

Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation.

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7 January 2021

Rational design of potent antagonists to the human growth hormone receptor

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7 January 2021

Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule

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7 January 2021

Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A

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7 January 2021

Small peptides as potent mimetics of the protein hormone erythropoietin

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7 January 2021

Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine

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7 January 2021

Mimicry of erythropoietin by a nonpeptide molecule

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7 January 2021

Efficiency of signalling through cytokine receptors depends critically on receptor orientation

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7 January 2021

Binding in the growth hormone receptor complex

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7 January 2021

Relationship between sugar chain structure and biological activity of recombinant human erythropoietin produced in Chinese hamster ovary cells

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7 January 2021

Thrombopoietin signal transduction: studies from cell lines and primary cells

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7 January 2021

Structure and function of the cytokine receptor superfamily

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7 January 2021

Signaling by the cytokine receptor superfamily

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7 January 2021

The Janus kinase family and signaling through members of the cytokine receptor superfamily

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7 January 2021

Thrombopoietin signal transduction requires functional JAK2, not TYK2

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7 January 2021

A structure-function analysis of serine/threonine phosphorylation of the thrombopoietin receptor, c-Mpl

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7 January 2021

Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation

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7 January 2021

Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain

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7 January 2021

TPO/c-mpl ligand induces tyrosine phosphorylation of multiple cellular proteins including proto-oncogene products, Vav and c-Cbl, and Ras signaling molecules

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7 January 2021

Thrombopoietin-induced conformational change in p53 lies downstream of the p44/p42 mitogen activated protein kinase cascade in the human growth factor-dependent cell line M07e

1 reference

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7 January 2021

STAT5-Dependent CyclinD1 and Bcl-xL expression in Bcr-Abl-transformed cells

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7 January 2021

STAT3-mediated differentiation and survival and of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27(Kip1)

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7 January 2021

Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21(WAF1/Cip1) by STAT5

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7 January 2021

Thrombopoietin (TPO) induces tyrosine phosphorylation and activation of STAT5 and STAT3.

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7 January 2021

Thrombopoietin induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in a human thrombopoietin-dependent cell line

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7 January 2021

The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl

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7 January 2021

Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathways

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7 January 2021

Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase

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7 January 2021

Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene

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7 January 2021

Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase

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7 January 2021

Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase

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7 January 2021

Activation of the c-fos enhancer by the erk MAP kinase pathway through two sequence elements: the c-fos AP-1 and p62TCF sites

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7 January 2021

Ras-stimulated Extracellular Signal-related Kinase 1 and RhoA Activities Coordinate Platelet-derived Growth Factor-induced G1 Progression through the Independent Regulation of Cyclin D1 and p27KIP1

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7 January 2021

Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1.

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7 January 2021

Phosphorylation regulates the microtubule‐destabilizing activity of stathmin and its interaction with tubulin

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7 January 2021

Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase

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7 January 2021

Control of Thrombopoietin-Induced Megakaryocytic Differentiation by the Mitogen-Activated Protein Kinase Pathway

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7 January 2021

Involvement of prolonged ras activation in thrombopoietin-induced megakaryocytic differentiation of a human factor-dependent hematopoietic cell line

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7 January 2021

Thrombopoietin induces activation of the phosphatidylinositol-3' kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL.

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7 January 2021

Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity

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7 January 2021

Erythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activation

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7 January 2021

Ras signalling and apoptosis

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7 January 2021

PI-3k-Akt axis inhibits apoptosis in normal human megakaryoblasts and is efficiently activated by thrombopoietin

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7 January 2021

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

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7 January 2021

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

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7 January 2021

Forkhead family transcription factor FKHRL1 is expressed in human megakaryocytes. Regulation of cell cycling as a downstream molecule of thrombopoietin signaling

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7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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7 January 2021

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

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7 January 2021

A Role for Cyclin D3 in the Endomitotic Cell Cycle

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7 January 2021

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

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7 January 2021

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

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7 January 2021

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

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7 January 2021

The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

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7 January 2021

Phosphorylation and activation of p70s6k by PDK1

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7 January 2021

Protein kinase C and c-myc gene activation pathways in thrombopoietin signal transduction.

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7 January 2021

Pleckstrin homology domains: a common fold with diverse functions

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7 January 2021

The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species

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7 January 2021

Defective B cell development and function in Btk-deficient mice

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7 January 2021

Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk.

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7 January 2021

Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling

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7 January 2021

Negative regulators of cytokine signaling

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7 January 2021

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

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7 January 2021

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

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7 January 2021

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

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7 January 2021

The SH2 domain-containing protein tyrosine phosphatase SHP-1 is induced by granulocyte colony-stimulating factor (G-CSF) and modulates signaling from the G-CSF receptor

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7 January 2021

Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis

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7 January 2021

Association of Hematopoietic Cell Phosphatase with c-Kit After Stimulation with c-Kit Ligand

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7 January 2021

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

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7 January 2021

5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells

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7 January 2021

The CIS family: negative regulators of JAK-STAT signaling

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7 January 2021

Negative regulators of cytokine signal transduction

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7 January 2021

A family of cytokine-inducible inhibitors of signalling

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7 January 2021

The CIS/JAB family: novel negative regulators of JAK signaling pathways

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7 January 2021

Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway

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7 January 2021

Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation

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7 January 2021

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

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7 January 2021

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

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7 January 2021

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

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7 January 2021

A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development

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7 January 2021

Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development

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7 January 2021

Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor

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7 January 2021

Granulocyte-macrophage colony-stimulating factor is not responsible for residual thrombopoiesis in mpl null mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900030-2

7 January 2021

Adult Mice With Targeted Mutation of the Interleukin-11 Receptor (IL11Ra) Display Normal Hematopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900030-2

7 January 2021

IL-3 does not contribute to platelet production in c-Mpl-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900030-2

7 January 2021

Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900030-2

7 January 2021

Actin reorganization and proplatelet formation in murine megakaryocytes: the role of protein kinase calpha

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900030-2

7 January 2021

10.1016/S1359-6101(01)00030-2

Identifiers

DOI

1 reference

2 August 2017

1 reference