The Receptor Binding Site of Human Interleukin-3 Defined by Mutagenesis and Molecular Modeling (Q34437425)

2 August 2017

title

The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling (English)

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2 August 2017

The Receptor Binding Site of Human Interleukin-3 Defined by Mutagenesis and Molecular Modeling (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.272.36.22630

13 November 2024

B. K. Klein

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9278420

13 November 2024

Y. Feng

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9278420

13 November 2024

C. A. McWherter

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13 November 2024

W. F. Hood

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9278420

13 November 2024

K. Paik

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13 November 2024

J. P. McKearn

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13 November 2024

language of work or name

English

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publication date

1 September 1997

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2 August 2017

5 September 1997

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9278420

full work available at URL

13 November 2024

http://www.jbc.org/content/272/36/22630.full.pdf

file format

Portable Document Format

online access status

open access

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https://api.elsevier.com/content/article/PII:S0021925819659399?httpAccept=text/xml

13 November 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.272.36.22630

https://api.elsevier.com/content/article/PII:S0021925819659399?httpAccept=text/plain

13 November 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.272.36.22630

https://syndication.highwire.org/content/doi/10.1074/jbc.272.36.22630

13 November 2024

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https://api.crossref.org/works/10.1074/JBC.272.36.22630

Journal of Biological Chemistry

13 November 2024

published in

1 reference

2 August 2017

volume

272

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2 August 2017

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2 August 2017

page(s)

22630-22641

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Control of granulocytes and macrophages: molecular, cellular, and clinical aspects

2 August 2017

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Saturation mutagenesis of human interleukin-3.

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A discontinuous eight-amino acid epitope in human interleukin-3 binds the alpha-chain of its receptor.

21 January 2018

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Determination of the secondary structures of proteins by circular dichroism and optical rotatory dispersion

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Potent interleukin 3 receptor agonist with selectively enhanced hematopoietic activity relative to recombinant human interleukin 3

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Crystallographic refinement by simulated annealing. Application to a 2.8 A resolution structure of aspartate aminotransferase.

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The interpretation of protein structures: Estimation of static accessibility

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

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Role of disulfide bridges in determining the biological activity of interleukin 3.

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Cloning and expression of interleukin-3 genes of chimpanzee and New World monkeys

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Cloning of a cDNA encoding ovine interleukin-3.

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Identification of key charged residues of human interleukin-5 in receptor binding and cellular activation.

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Hematopoietic activity of granulocyte/macrophage colony-stimulating factor is dependent upon two distinct regions of the molecule: functional analysis based upon the activities of interspecies hybrid growth factors

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The crystal structure of affinity-matured human growth hormone at 2 A resolution

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Molecular modeling of the GM-CSF and IL-3 receptor complexes

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A hot spot of binding energy in a hormone-receptor interface

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Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding

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21 January 2018

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Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF

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Residue 21 of human granulocyte-macrophage colony-stimulating factor is critical for biological activity and for high but not low affinity binding

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13 November 2024

Identifiers

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2 August 2017

1 reference