Double-strand breaks and tumorigenesis (Q34421810)

2 August 2017

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title

Double-strand breaks and tumorigenesis (English)

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2 August 2017

Pierce AJ

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2 August 2017

Stark JM

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2 August 2017

Araujo FD

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2 August 2017

Moynahan ME

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2 August 2017

Berwick M

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2 August 2017

Jasin M

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2 August 2017

publication date

1 November 2001

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2 August 2017

published in

Trends in Cell Biology

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2 August 2017

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2 August 2017

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2 August 2017

page(s)

S52-9

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Chromosomal stability and the DNA double-stranded break connection

2 August 2017

cites work

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A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53

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Targeted disruption of the Rad51 gene leads to lethality in embryonic mice

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The importance of repairing stalled replication forks

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Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice

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Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice

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Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group.

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The contribution of homologous recombination in preserving genome integrity in mammalian cells

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A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

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DNA damage-dependent nuclear dynamics of the Mre11 complex

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In search of the tumour-suppressor functions of BRCA1 and BRCA2

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Insights into the functions of BRCA1 and BRCA2.

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Impaired DNA damage response in cells expressing an exon 11-deleted murine Brca1 variant that localizes to nuclear foci

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Brca1 controls homology-directed DNA repair

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Brca1 required for T cell lineage development but not TCR loci rearrangement.

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Direct DNA binding by Brca1

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Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.

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Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

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7 January 2021

Apparent human BRCA1 knockout caused by mispriming during polymerase chain reaction: implications for genetic testing

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A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage.

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Tumorigenesis in mice carrying a truncating Brca1 mutation

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Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

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Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice

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Breast carcinomas arising in carriers of mutations in BRCA1 or BRCA2: are they prognostically different?

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7 January 2021

Gene-Expression Profiles in Hereditary Breast Cancer

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7 January 2021

Identification of Rad51 alteration in patients with bilateral breast cancer

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7 January 2021

A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers

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7 January 2021

Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs

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7 January 2021

A novel human rad54 homologue, Rad54B, associates with Rad51

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7 January 2021

Mouse RAD54 affects DNA double-strand break repair and sister chromatid exchange

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7 January 2021

Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination

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7 January 2021

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

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7 January 2021

Disruption of muREC2/RAD51L1 in mice results in early embryonic lethality which can Be partially rescued in a p53(-/-) background

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7 January 2021

Midgestation lethality in mice deficient for the RecA-related gene, Rad51d/Rad51l3.

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7 January 2021

Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.

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7 January 2021

Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation

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7 January 2021

Mutations in the RAD54 recombination gene in primary cancers

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7 January 2021

DNA repair gene polymorphisms, bulky DNA adducts in white blood cells and bladder cancer in a case-control study

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7 January 2021

Genetic polymorphisms in DNA repair genes and risk of lung cancer.

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7 January 2021

The Mre11 complex and ATM: collaborating to navigate S phase

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DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders

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ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

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Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

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7 January 2021

Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

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7 January 2021

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

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7 January 2021

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

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7 January 2021

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

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7 January 2021

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

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7 January 2021

Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase

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7 January 2021

Analysis of ku80-mutant mice and cells with deficient levels of p53

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7 January 2021

Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity

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7 January 2021

Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer

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7 January 2021

10.1016/S0962-8924(01)02149-3

Identifiers

DOI

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2 August 2017

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