Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds. (Q34429722)

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15 December 2019

title

Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds (English)

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15 December 2019

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15 December 2019

Motomu Shimaoka

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15 December 2019

Chafen Lu

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15 December 2019

Tsan Xiao

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15 December 2019

Junichi Takagi

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15 December 2019

Timothy A Springer

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15 December 2019

language of work or name

English

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publication date

4 December 2002

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Proceedings of the National Academy of Sciences of the United States of America

15 December 2019

published in

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15 December 2019

volume

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15 December 2019

issue

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15 December 2019

page(s)

16737-16741

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Conformational regulation of integrin structure and function

15 December 2019

cites work

1 reference

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Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo

6 July 2018

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Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties

6 July 2018

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An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.

6 July 2018

1 reference

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Controlling kinesin by reversible disulfide cross-linking. Identifying the motility-producing conformational change

6 July 2018

1 reference

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An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain

6 July 2018

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6 July 2018

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Computational design of an integrin I domain stabilized in the open high affinity conformation

6 July 2018

1 reference

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Structural basis of collagen recognition by integrin alpha2beta1

6 July 2018

1 reference

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Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain

6 July 2018

1 reference

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Conformational changes in tertiary structure near the ligand binding site of an integrin I domain.

6 July 2018

1 reference

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JOY: protein sequence-structure representation and analysis.

6 July 2018

1 reference

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Ligand recognition by the I domain-containing integrins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139213

Extreme stabilization of a thermolysin-like protease by an engineered disulfide bond

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139213

Two conformations of the integrin A-domain (I-domain): a pathway for activation?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139213

Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139213

A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen

6 July 2018

1 reference

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Regulation of integrin-mediated myeloid cell adhesion to fibronectin: influence of disulfide reducing agents, divalent cations and phorbol ester

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139213

Disulfide mutants of barnase. I: Changes in stability and structure assessed by biophysical methods and X-ray crystallography

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139213

Model building of disulfide bonds in proteins with known three-dimensional structure

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139213

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139213

Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.252633099

Global flexibility in a sensory receptor: a site-directed cross-linking approach

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.252633099

Enhanced aggregation of human neutrophils by MnCl2 or DTT differentiates the roles of L-selectin and beta 2-integrins

21 January 2018

1 reference

12 December 2020

The alpha subunit cytoplasmic domain regulates the assembly and adhesiveness of integrin lymphocyte function-associated antigen-1

1 reference

12 December 2020

State-dependent disulfide cross-linking in rhodopsin

1 reference

12 December 2020

Engineered disulfide bonds in staphylococcal nuclease: effects on the stability and conformation of the folded protein

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.252633099

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12466503%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12466503%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

PubMed publication ID

12466503

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12466503%20AND%20SRC:MED&resulttype=core&format=json