Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins (Q34376497)

1 August 2017

title

Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins (English)

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1 August 2017

Bradley E Bernstein

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1 August 2017

J Keith Joung

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1 August 2017

Morgan L Maeder

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1 August 2017

James F Angstman

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1 August 2017

Marcy E Richardson

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1 August 2017

Samantha J Linder

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1 August 2017

Vincent M Cascio

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1 August 2017

Shengdar Q Tsai

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1 August 2017

Quan H Ho

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1 August 2017

Jeffry D Sander

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1 August 2017

Deepak Reyon

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1 August 2017

Joseph F Costello

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1 August 2017

Miles F Wilkinson

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1 August 2017

publication date

9 October 2013

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1 August 2017

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

1137-1142

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The RHOX homeobox gene cluster is selectively expressed in human oocytes and male germ cells.

1 August 2017

cites work

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DNA methylation: roles in mammalian development

6 July 2018

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Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a-Dnmt3L single-chain fusion protein with increased DNA methylation activity

6 July 2018

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TALENs: a widely applicable technology for targeted genome editing

6 July 2018

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Functions of DNA methylation: islands, start sites, gene bodies and beyond

6 July 2018

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FLASH assembly of TALENs for high-throughput genome editing

6 July 2018

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Epigenetic reprogramming of cancer cells via targeted DNA methylation.

6 July 2018

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Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites

6 July 2018

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Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

6 July 2018

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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3858462

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3858462

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3858462

A TALE nuclease architecture for efficient genome editing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3858462

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

6 July 2018

1 reference

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Three epigenetic drugs up-regulate homeobox gene Rhox5 in cancer cells through overlapping and distinct molecular mechanisms

6 July 2018

1 reference

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

6 July 2018

1 reference

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DNA methylation landscapes: provocative insights from epigenomics

6 July 2018

1 reference

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Genome-epigenome interactions in cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3858462

Developmental- and differentiation-specific patterns of human gamma- and beta-globin promoter DNA methylation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3858462

Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3858462

Site-selective in vivo targeting of cytosine-5 DNA methylation by zinc-finger proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3858462

Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity.

6 July 2018

1 reference

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Characterisation of site-biased DNA methyltransferases: specificity, affinity and subsite relationships

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3858462

DNA methylation patterns and epigenetic memory

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3858462

Epigenetic reprogramming in mammalian development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3858462

Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells

6 July 2018

1 reference

Optical control of mammalian endogenous transcription and epigenetic states

21 January 2018

1 reference

Gene-specific targeting of H3K9 methylation is sufficient for initiating repression in vivo.

21 January 2018

1 reference

Specific targeting of cytosine methylation to DNA sequences in vivo

21 January 2018

1 reference

In vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase.

21 January 2018

1 reference

Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification

21 January 2018

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Cytosine methylation targetted to pre-determined sequences

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24108092

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Locus-specific editing of histone modifications at endogenous enhancers

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NBT.2726

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1 August 2017

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1 August 2017

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