Do mammalian cytochrome P450s show multiple ligand access pathways and ligand channelling? (Q34360317)

1 August 2017

title

Do mammalian cytochrome P450s show multiple ligand access pathways and ligand channelling? (English)

1 reference

1 August 2017

Peter J Winn

0 references

Rebecca C Wade

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Karin Schleinkofer

1 reference

1 August 2017

Sudarko

series ordinal

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1 August 2017

Susanne K Lüdemann

series ordinal

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1 August 2017

publication date

1 June 2005

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1 August 2017

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

584-589

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A survey of active site access channels in cytochromes P450.

1 August 2017

cites work

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6 July 2018

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Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix

6 July 2018

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Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site

6 July 2018

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Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes

6 July 2018

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A rational approach to Re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5.

6 July 2018

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Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine

6 July 2018

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Pivotal role of water in the mechanism of P450BM-3

6 July 2018

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How do substrates enter and products exit the buried active site of cytochrome P450cam? 1. Random expulsion molecular dynamics investigation of ligand access channels and mechanisms.

6 July 2018

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6 July 2018

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Engineering microsomal cytochrome P450 2C5 to be a soluble, monomeric enzyme. Mutations that alter aggregation, phospholipid dependence of catalysis, and membrane binding

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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An inhibitory monoclonal antibody binds in close proximity to a determinant for substrate binding in cytochrome P450IIC5

6 July 2018

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A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

6 July 2018

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Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants

21 January 2018

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Estriol bound and ligand-free structures of sterol 14alpha-demethylase

21 January 2018

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How do substrates enter and products exit the buried active site of cytochrome P450cam? 2. Steered molecular dynamics and adiabatic mapping of substrate pathways.

21 January 2018

1 reference

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Binding of camphor to Pseudomonas putida cytochrome p450(cam): steady-state and picosecond time-resolved fluorescence studies

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16028306

12 December 2020

inferred from PubMed ID database lookup

Identification of rabbit microsomal cytochrome P-450 isozyme, form 1, as a hepatic progesterone 21-hydroxylase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16028306

12 December 2020

inferred from PubMed ID database lookup

Rabbit hepatic progesterone 21-hydroxylase exhibits a bimodal distribution of activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16028306

12 December 2020

inferred from PubMed ID database lookup

Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOR.7400420

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/SJ.EMBOR.7400420

1 reference

1 August 2017

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1 August 2017

1 reference