Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase (Q34365993)

1 August 2017

title

Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase (English)

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1 August 2017

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Shigetsugu Hatakeyama

object named as

Shigetsugu Hatakeyama

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Minoru Yoshida

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Takumi Kamura

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1 August 2017

Taichi Hara

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1 August 2017

Masaki Matsumoto

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1 August 2017

Noriko Ishida

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1 August 2017

Fumihiko Okumura

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1 August 2017

Keiko Nakayama

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1 August 2017

Keiichi I Nakayama

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1 August 2017

publication date

7 November 2004

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1 August 2017

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

1229-1235

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Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

1 August 2017

cites work

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7 January 2021

Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing

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7 January 2021

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

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7 January 2021

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

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7 January 2021

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

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7 January 2021

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

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7 January 2021

Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway

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7 January 2021

Skp2-mediated degradation of p27 regulates progression into mitosis

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7 January 2021

Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export

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7 January 2021

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

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7 January 2021

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

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7 January 2021

Identification of a glialblastoma cell differentiation factor-related gene mRNA in human microvascular endothelial cells

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7 January 2021

SPRY domains in ryanodine receptors (Ca(2+)-release channels).

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7 January 2021

Proteins containing the UBA domain are able to bind to multi-ubiquitin chains

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7 January 2021

Ubiquitin-associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi-ubiquitin chain assembly

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7 January 2021

Trichostatin and leptomycin. Inhibition of histone deacetylation and signal-dependent nuclear export

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7 January 2021

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

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7 January 2021

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

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7 January 2021

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

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7 January 2021

Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

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7 January 2021

Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.

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7 January 2021

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

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7 January 2021

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

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7 January 2021

Plat-E: an efficient and stable system for transient packaging of retroviruses

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7 January 2021

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

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7 January 2021

Identifiers

DOI

10.1038/NCB1194

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Dimensions Publication ID

1 August 2017

1011906803

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