A mutant of human papillomavirus type 16 E6 deficient in binding alpha-helix partners displays reduced oncogenic potential in vivo. (Q34352200)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12438630%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

title

A mutant of human papillomavirus type 16 E6 deficient in binding alpha-helix partners displays reduced oncogenic potential in vivo (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12438630%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

main subject

human papilloma virus

1 reference

human papillomavirus

29 September 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12438630%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

Marie Nguyen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12438630%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

Shiyu Song

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12438630%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

Amy Liem

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12438630%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

Yun Liu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12438630%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

Paul F Lambert

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12438630%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

language of work or name

English

0 references

publication date

1 December 2002

1 reference

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15 December 2019

1 reference

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15 December 2019

volume

1 reference

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15 December 2019

issue

1 reference

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15 December 2019

page(s)

13039-13048

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12438630%20AND%20SRC:MED&resulttype=core&format=json

Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP

15 December 2019

cites work

1 reference

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Human papillomavirus type 16 E6-induced degradation of E6TP1 correlates with its ability to immortalize human mammary epithelial cells

6 July 2018

1 reference

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Solution structure determination and mutational analysis of the papillomavirus E6 interacting peptide of E6AP

6 July 2018

1 reference

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Gps2, a protein partner for human papillomavirus E6 proteins

6 July 2018

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Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins

6 July 2018

1 reference

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Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase

6 July 2018

1 reference

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Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins

6 July 2018

1 reference

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Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase

6 July 2018

1 reference

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Competitive binding to a charged leucine motif represses transformation by a papillomavirus E6 oncoprotein

6 July 2018

1 reference

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PKN binds and phosphorylates human papillomavirus E6 oncoprotein

6 July 2018

1 reference

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Human papillomavirus types 16 E6 and E7 contribute differently to carcinogenesis

6 July 2018

1 reference

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Twenty years of p53 research: structural and functional aspects of the p53 protein

6 July 2018

1 reference

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The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300.

6 July 2018

1 reference

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Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination

6 July 2018

1 reference

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Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells

6 July 2018

1 reference

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The human papillomavirus type 16 E6 oncoprotein can down-regulate p53 activity by targeting the transcriptional coactivator CBP/p300.

6 July 2018

1 reference

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Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination.

6 July 2018

1 reference

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The human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals

6 July 2018

1 reference

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Inhibition of Bak-induced apoptosis by HPV-18 E6.

6 July 2018

1 reference

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The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation

6 July 2018

1 reference

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E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box

6 July 2018

1 reference

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Human papillomavirus oncoprotein E6 binds to the C-terminal region of human minichromosome maintenance 7 protein

6 July 2018

1 reference

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Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity

6 July 2018

1 reference

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The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.

6 July 2018

1 reference

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Human papillomavirus type 16 E6 and E7 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways

6 July 2018

1 reference

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The identification of a conserved binding motif within human papillomavirus type 16 E6 binding peptides, E6AP and E6BP.

6 July 2018

1 reference

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Association of Bovine Papillomavirus Type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif

6 July 2018

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A comparative analysis of the interactions of the E6 proteins from cutaneous and genital papillomaviruses with p53 and E6AP in correlation to their transforming potential

6 July 2018

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Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein

6 July 2018

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Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein

6 July 2018

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The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton.

6 July 2018

1 reference

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E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts

6 July 2018

1 reference

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Human papillomavirus type 16 E6 gene cooperates with EJ-ras to immortalize primary mouse cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136691

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136691

The E6 gene of human papillomavirus type 16 is sufficient for transformation of baby rat kidney cells in cotransfection with activated Ha-ras

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136691

Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136691

E6-AP directs the HPV E6-dependent inactivation of p53 and is representative of a family of structurally and functionally related proteins.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136691

HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136691

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136691

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136691

A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136691

Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136691

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136691

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136691

Spontaneous lesions in aging FVB/N mice

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12438630

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The bovine papillomavirus E6 protein binds to the LD motif repeats of paxillin and blocks its interaction with vinculin and the focal adhesion kinase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12438630

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of an alpha helical motif sufficient for association with papillomavirus E6

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12438630

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/JVI.76.24.13039-13048.2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12438630%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12438630%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

PubMed publication ID

12438630

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12438630%20AND%20SRC:MED&resulttype=core&format=json