Genetic analysis of high-risk e6 in episomal maintenance of human papillomavirus genomes in primary human keratinocytes. (Q34355987)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12388696%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

title

Genetic analysis of high-risk e6 in episomal maintenance of human papillomavirus genomes in primary human keratinocytes (English)

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14 December 2019

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human papilloma virus

1 reference

human papillomavirus

29 September 2024

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14 December 2019

Regina B Park

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14 December 2019

language of work or name

English

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publication date

1 November 2002

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14 December 2019

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14 December 2019

volume

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14 December 2019

issue

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14 December 2019

page(s)

11359-11364

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12388696%20AND%20SRC:MED&resulttype=core&format=json

Human papillomavirus oncoprotein E6 inactivates the transcriptional coactivator human ADA3

14 December 2019

cites work

1 reference

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Human papillomavirus type 31 replication modes during the early phases of the viral life cycle depend on transcriptional and posttranscriptional regulation of E1 and E2 expression

6 July 2018

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E box-dependent activation of telomerase by human papillomavirus type 16 E6 does not require induction of c-myc

6 July 2018

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Telomerase activation by human papillomavirus type 16 E6 protein: induction of human telomerase reverse transcriptase expression through Myc and GC-rich Sp1 binding sites

6 July 2018

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Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein

6 July 2018

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Human papillomavirus type 16 E6-induced degradation of E6TP1 correlates with its ability to immortalize human mammary epithelial cells

6 July 2018

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Gps2, a protein partner for human papillomavirus E6 proteins

6 July 2018

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The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle

6 July 2018

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Competitive binding to a charged leucine motif represses transformation by a papillomavirus E6 oncoprotein

6 July 2018

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PKN binds and phosphorylates human papillomavirus E6 oncoprotein

6 July 2018

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Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis

6 July 2018

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6 July 2018

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The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-alpha

6 July 2018

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Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation

6 July 2018

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Establishment of the human papillomavirus type 16 (HPV-16) life cycle in an immortalized human foreskin keratinocyte cell line

6 July 2018

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Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells

6 July 2018

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Human papillomavirus type 31 oncoproteins E6 and E7 are required for the maintenance of episomes during the viral life cycle in normal human keratinocytes

6 July 2018

1 reference

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p14ARF links the tumour suppressors RB and p53.

6 July 2018

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Comparison of human papillomavirus type 18 (HPV-18) E6-mediated degradation of p53 in vitro and in vivo reveals significant differences based on p53 structure and cell type but little difference with respect to mutants of HPV-18 E6.

6 July 2018

1 reference

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Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity

6 July 2018

1 reference

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The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.

6 July 2018

1 reference

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Association of Bovine Papillomavirus Type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif

6 July 2018

1 reference

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Destabilization of the RB tumor suppressor protein and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

Synthesis of infectious human papillomavirus type 18 in differentiating epithelium transfected with viral DNA

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

6 July 2018

1 reference

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Initiation of DNA synthesis by human papillomavirus E7 oncoproteins is resistant to p21-mediated inhibition of cyclin E-cdk2 activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

p53 in signaling checkpoint arrest or apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

In vitro synthesis of oncogenic human papillomaviruses requires episomal genomes for differentiation-dependent late expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

Telomerase activation by the E6 gene product of human papillomavirus type 16.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

Human papillomavirus E7 oncoproteins bind a single form of cyclin E in a complex with cdk2 and p107.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

Mutational analysis of human papillomavirus type 16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

Association of the human papillomavirus type 16 E7 protein with the S-phase-specific E2F-cyclin A complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

Mouse cells transformed by bovine papillomavirus contain only extrachromosomal viral DNA sequences

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

Selective extraction of polyoma DNA from infected mouse cell cultures

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

Role of the human papillomavirus oncoproteins in transformation and carcinogenic progression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

Biochemical and biological differences between E7 oncoproteins of the high- and low-risk human papillomavirus types are determined by amino-terminal sequences

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

Single amino acid substitutions in "low-risk" human papillomavirus (HPV) type 6 E7 protein enhance features characteristic of the "high-risk" HPV E7 oncoproteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

Role of a p53 polymorphism in the development of human papillomavirus-associated cancer

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=136782

The domain of p53 required for binding HPV 16 E6 is separable from the degradation domain

27 October 2018

1 reference

12 December 2020

HPV E6 targeted degradation of the discs large protein: evidence for the involvement of a novel ubiquitin ligase

1 reference

12 December 2020

Identification of an alpha helical motif sufficient for association with papillomavirus E6

1 reference

12 December 2020

The E7 protein of human papillomavirus type 16 sensitizes primary human keratinocytes to apoptosis

1 reference

12 December 2020

Cellular targets of the oncoproteins encoded by the cancer associated human papillomaviruses

1 reference

12 December 2020

10.1128/JVI.76.22.11359-11364.2002

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12388696%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12388696%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

PubMed publication ID

12388696

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12388696%20AND%20SRC:MED&resulttype=core&format=json